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Nitazox100 mg/5 m
Incepta Pharmaceuticals Ltd.
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Dianide100 mg/5 ml
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Medicine overview
Indications of Dianide 100 mg/5 ml
Dianide 100 mg/5 ml is indicated for the treatment of diarrhea caused by Cryptosporidium parvumGiardia lamblia and Entamoeba histolytica.
Theropeutic Class
Anti-diarrhoeal Antiprotozoal
Pharmacology
Dianide 100 mg/5 ml is a synthetic antiprotozoal agent for oral administration.
Absorption
The antiprotozoal activity of Dianide 100 mg/5 ml is believed to be interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction.
Metabolism
This reaction is essential for anaerobic energy metabolism of the protozoa. Dianide 100 mg/5 ml and its metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Dosage & Administration of Dianide 100 mg/5 ml
Age 1-3 years
Dosage:1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days
Age 4-11 years
Dosage:2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days
Age 12 years or above
Dosage:5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days
Notes:It is recommended to be administered with food
| Condition | Dosage | Notes |
|---|---|---|
| Age 1-3 years | 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days | |
| Age 4-11 years | 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days | |
| Age 12 years or above | 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days | It is recommended to be administered with food |
Dosage of Dianide 100 mg/5 ml
Age 1-3 years
Dosage:1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days
Age 4-11 years
Dosage:2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days
Age 12 years or above
Dosage:5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days
Notes:It is recommended to be administered with food
| Condition | Dosage | Notes |
|---|---|---|
| Age 1-3 years | 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days | |
| Age 4-11 years | 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days | |
| Age 12 years or above | 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days | It is recommended to be administered with food |
Interaction of Dianide 100 mg/5 ml
It is highly bound to plasma protein. Therefore, caution should be exercised when administering Dianide 100 mg/5 ml concurrently with other highly plasma protein-bound drugs with narrow therapeutic index.
Contraindications
It is contraindicated in patients with known hypersensitivity to Dianide 100 mg/5 ml or any components of the preparation.
Side Effects of Dianide 100 mg/5 ml
The most frequent side effects, reported by Dianide 100 mg/5 ml are abdominal pain, vomiting and headache. These side effects are typically mild and transient in nature. Very rare side effects include- nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine etc.
Pregnancy & Lactation
US FDA pregnancy category of Dianide 100 mg/5 ml is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Dianide 100 mg/5 ml have been shown to be excreted in human milk. So, caution should be exercised when Dianide 100 mg/5 ml is administered during lactation.
Precautions & Warnings
Dianide 100 mg/5 ml must be administered with caution to patients with hepatic & biliary disease and to patients with renal disease.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Drug Classes
Anti-diarrhoeal Antiprotozoal
Mode Of Action
Dianide 100 mg/5 ml is a synthetic antiprotozoal agent for oral administration. The antiprotozoal activity of Dianide 100 mg/5 ml is believed to be interference with the Pyruvate Ferredoxin Oxido Reductase (PFOR) enzyme-dependant electron transfer reaction. This reaction is essential for anaerobic energy metabolism of the protozoa. Dianide 100 mg/5 ml and its metabolites, tizoxanid are active in vitro in inhibiting the growth of sporozoites and oocyst of Cryptosporidium parvum and trophozoites of Giardia lamblia.
Pregnancy
US FDA pregnancy category of Dianide 100 mg/5 ml is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Dianide 100 mg/5 ml have been shown to be excreted in human milk. So, caution should be exercised when Dianide 100 mg/5 ml is administered during lactation.
Frequently Asked Questions
What is Dianide 100 mg/5 ml used for?
Nitazoxanide is indicated for the treatment of diarrhea caused by Cryptosporidium parvum, Giardia lamblia and Entamoeba histolytica.
What is the dosage of Dianide 100 mg/5 ml?
Age 1-3 years: 1 tea-spoonfull or 5 ml suspension every 12 hours for 3 days. Age 4-11 years: 2 tea-spoonfulls or 10 ml suspension every 12 hours for 3 days.Age 12 years or above: 5 tea-spoonfulls (25 ml) suspension or 1 tablet every 12 hours for 3 days. It is recommended to be administered with food.
What are the side effects of Dianide 100 mg/5 ml?
The most frequent side effects, reported by Nitazoxanide are abdominal pain, vomiting and headache. These side effects are typically mild and transient in nature. Very rare side effects include- nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine & SGPT level, pruritus, rhinitis, sweating, dizziness, discolored urine etc.
Who should not take Dianide 100 mg/5 ml?
It is contraindicated in patients with known hypersensitivity to Nitazoxanide or any components of the preparation.
What precautions should be taken with Dianide 100 mg/5 ml?
Nitazoxanide must be administered with caution to patients with hepatic & biliary disease and to patients with renal disease.
Is Dianide 100 mg/5 ml safe during pregnancy and breastfeeding?
US FDA pregnancy category of Nitazoxanide is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Nitazoxanide have been shown to be excreted in human milk. So, caution should be exercised when Nitazoxanide is administered d…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.