Diovan160 mg

Diovan 160 mg is indicated: For hypertension To reduce hospitalizations in patients with congestive heart failure To reduce death in patients who developed congestive heart failure after myocardial infarction

Angiotensin-ll receptor blocker

Diovan 160 mg is an oral medication that belongs to a class of drugs called angiotensin receptor blockers (ARBs). It is orally active and specific angiotensin II antagonist acting on the AT1 subtype. Angiotensin's attachment to the receptors cause the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure (hypertension). Diovan 160 mg blocks the angiotensin II receptor. By blocking the action of angiotensin, Diovan 160 mg dilates blood vessels and reduces blood pressure without affecting pulse rate. Diovan 160 mg has much greater affinity (about 20,000-fold) for the AT1 receptor than for the AT2 receptor. It does not bind or block other hormone receptors or ion channels known to be important in cardiovascular regulation.

Hypertension: The usual dose of Diovan 160 mg is 80 to 160 mg once daily. The maximum dose is 320 mg daily. Maximum blood pressure reduction occurs within 4 weeks. Heart failure: The usual dose is 40 mg twice daily and may be increased to 80-160 mg twice daily. Post-Myocardial Infarction: The initial dose after myocardial infarction is 20 mg twice daily. The dose should be increased with a target of 160 mg daily if tolerated without side effects.

Administration of Diovan 160 mg with food decreases the absorption of Diovan 160 mg by about 40%, so it should be taken on an empty stomach. No initial dosage adjustment is required for elderly patients with mild to moderate renal and hepatic insufficiency.

No drug interactions of clinical significance have been found. Compounds which have been studied in clinical trials include Cimetidine, Warfarin, Furosemide, Digoxin, Atenolol, Indomethacin, Hydrochlorothiazide, Amlodipine and GlibenclamideAs Diovan 160 mg is not metabolized to a significant extent, clinically relevant drug-drug interactions in the form of metabolic induction or inhibition of the cytochrome P450 system are not expected with Diovan 160 mg. Although Diovan 160 mg is highly bound to plasma proteins, in vitrostudies have not shown any interaction at this level with a range of molecules which are also highly protein bound, such as Diclofenac, Furosemide, and Warfarin. Concomitant use of potassium sparing diuretics (e.g., Spironolactone, Triamterene, Amiloride) potassium supplements, or salt substitutes containing potassium may lead to increase in serum potassium. If co medication is considered necessary, caution is advisable

Diovan 160 mg is contraindicated in patients who are hypersensitive to any component of this product.

Diovan 160 mg is generally well tolerated and side effects are rare. The most common side effects include headache, dizziness, fatigue, abdominal pain, cough, diarrhea and nausea. Patient may also experience hyperkalemia, impotency, reduced renal function, allergic reactions, dyspnea, constipation, back pain, muscle cramps, rash, anxiety, insomnia and vertigo. Hypotension may also occur if patient have been taking diuretics along with Diovan 160 mg.

Pregnancy: Diovan 160 mg should not be used in pregnancy, as in 2nd and 3rd trimester it can cause injury and even death to fetus. When pregnancy is detected, Diovan 160 mg should be stopped as soon as possible.Nursing mothers: It is not known whether Diovan 160 mg is excreted in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Impaired Hepatic Function: As the majority of Diovan 160 mg is eliminated in the bile, care should be exercised in patients with mild to moderate hepatic impairment including biliary obstructive disorder.Impaired Renal Function: Dosage reduction or discontinuation may be required with patients having pre-existing renal impairment.Heart Failure and Myocardial Infarction: Caution should be exercised when initiating therapy in patients with heart failure and post-myocardial infarction patients.

Limited data are available related to overdosage in humans. The most likely manifestations of overdosage would be hypotension and tachycardia, bradycardia could occur from parasympathetic (vagal) stimulation. If excessive hypotension occurs, the patient should be placed in the supine position and if necessary, has to be given an intravenous infusion of normal saline.

Store between 15-30° C. Protect from moisture and heat.

Pediatric use: Safety and effectiveness in paediatric patients have not been established.Geriatric use: No overall difference in the efficacy or safety of Diovan 160 mg was observed in this patient population, but greater sensitivity of some elderly persons cannot be ruled out.Hepatic Impairment: Mild to moderate: Max: 80 mg once daily. Severe: Contraindicated.

Angiotensin-ll receptor blocker

Diovan 160 mg is an oral medication that belongs to a class of drugs called angiotensin receptor blockers (ARBs). It is orally active and specific angiotensin II antagonist acting on the AT1 subtype. Angiotensin's attachment to the receptors cause the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure (hypertension). Diovan 160 mg blocks the angiotensin II receptor. By blocking the action of angiotensin, Diovan 160 mg dilates blood vessels and reduces blood pressure without affecting pulse rate. Diovan 160 mg has much greater affinity (about 20,000-fold) for the AT1 receptor than for the AT2 receptor. It does not bind or block other hormone receptors or ion channels known to be important in cardiovascular regulation.

Pregnancy: Diovan 160 mg should not be used in pregnancy, as in 2nd and 3rd trimester it can cause injury and even death to fetus. When pregnancy is detected, Diovan 160 mg should be stopped as soon as possible.Nursing mothers: It is not known whether Diovan 160 mg is excreted in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric use: Safety and effectiveness in paediatric patients have not been established.Geriatric use: No overall difference in the efficacy or safety of Diovan 160 mg was observed in this patient population, but greater sensitivity of some elderly persons cannot be ruled out.Hepatic Impairment: Mild to moderate: Max: 80 mg once daily. Severe: Contraindicated.