Eluxan100 mg
Tablet
Eluxadoline
Ziska Pharmaceuticals Ltd.
Product Code : 5665
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Medicine overview
Indications of Eluxan 100 mg
Eluxan 100 mg is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS-D).
Theropeutic Class
Carboxylic acids and derivatives, Prokinetic drugs
Pharmacology
Eluxan 100 mg is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxan 100 mg works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.
Dosage & Administration of Eluxan 100 mg
The recommended dosage in adults is 100 mg twice daily taken with food.The recommended dosage is 75 mg twice daily taken with food in patients who:
are unable to tolerate the 100 mg dose.
are receiving concomitant OATP1B1 inhibitors.
have mild or moderate hepatic impairment.
Discontinue Eluxan 100 mg in patients who develop severeconstipation.If a dose is missed, take the next dose at the regular time; do not take 2 doses at once
Dosage of Eluxan 100 mg
The recommended dosage in adults is 100 mg twice daily taken with food.The recommended dosage is 75 mg twice daily taken with food in patients who:
are unable to tolerate the 100 mg dose.
are receiving concomitant OATP1B1 inhibitors.
have mild or moderate hepatic impairment.
Discontinue Eluxan 100 mg in patients who develop severeconstipation.If a dose is missed, take the next dose at the regular time; do not take 2 doses at once
Interaction of Eluxan 100 mg
Oral Contraceptive, Cyclosporine, Probenecid, Rosuvastatin.
Contraindications
Known or suspected biliary duct obstruction, sphincter of oddi disease or dysfunction & pancreatitis.
Side Effects of Eluxan 100 mg
Most common adverse reactions are constipation, nausea andabdominal pain.
Pregnancy & Lactation
Pregnancy: Not established.Lactation: Not established.
Precautions & Warnings
Sphincter of Oddi spasm and Pancreatitis.Patients who should be monitored closely-
without a gallbladder
with new or worsening abdominal pain
with nausea and vomiting
with acute biliary pain
with liver or pancreatic enzyme elevation
Storage Conditions
Store in a cool & dry place, protect from light. Keep out of the reach of children.
Use In Special Populations
Pediatric Use: Safety and effectiveness in pediatric patients have not been established.Hepatic Impairment: It is contraindicated in patients with severe hepatic impairment.
Drug Classes
Carboxylic acids and derivatives, Prokinetic drugs
Mode Of Action
Eluxan 100 mg is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxan 100 mg works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.
Pregnancy
Pregnancy: Not established.Lactation: Not established.
Pediatric Uses
Pediatric Use: Safety and effectiveness in pediatric patients have not been established.Hepatic Impairment: It is contraindicated in patients with severe hepatic impairment.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.
