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Febustat80 mg
Incepta Pharmaceuticals Ltd.
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Feluric80 mg
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Medicine overview
Indications of Feluric 80 mg
Feluric 80 mg is indicated for the chronic management of hyperuricemia in patients with gout. Feluric 80 mg is not recommended for the treatment of asymptomatic hyperuricemia.
Theropeutic Class
Drugs used in Gout
Pharmacology
Feluric 80 mg is a non-purine, selective xanthine oxidase (XO) inhibitor.
Absorption
It decreases serum uric acid level by inhibiting xanthine oxidase, which is responsible for uric acid production.
Distribution
Xanthine oxidase breaks down hypoxanthine to xanthine and thus to uric acid.
Metabolism
Feluric 80 mg is not expected to inhibit other enzymes involved in purine and pyrimidine synthesis and metabolism at therapeutic concentrations.
Excretion
Feluric 80 mg is not expected to inhibit other enzymes involved in purine and pyrimidine synthesis and metabolism at therapeutic concentrations.
Dosage & Administration of Feluric 80 mg
Feluric 80 mg is recommended at 40 mg or 80 mg once daily. The recommended starting dose of Feluric 80 mg is 40 mg once daily. For patients who do not achieve a serum uric acid less than 6 mg /dL after 2 weeks with 40 mg, Feluric 80 mg 80 mg is recommended. Feluric 80 mg can be administered without regard to food or antacid use. No dose adjustment is necessary when administering Feluric 80 mg to patients with mild to moderate renal or hepatic impairment.
Dosage of Feluric 80 mg
Feluric 80 mg is recommended at 40 mg or 80 mg once daily. The recommended starting dose of Feluric 80 mg is 40 mg once daily. For patients who do not achieve a serum uric acid less than 6 mg /dL after 2 weeks with 40 mg, Feluric 80 mg 80 mg is recommended. Feluric 80 mg can be administered without regard to food or antacid use. No dose adjustment is necessary when administering Feluric 80 mg to patients with mild to moderate renal or hepatic impairment.
Interaction of Feluric 80 mg
Concomitant administration of Feluric 80 mg with azathioprine, mercaptopurine or theophylline could increase plasma concentrations of these drugs resulting in severe toxicity.
Contraindications
Feluric 80 mg is contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline.
Side Effects of Feluric 80 mg
The most common adverse events associated with the use of Feluric 80 mg may include liver function abnormalities, nausea, arthralgia, and rash.
Pregnancy & Lactation
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Feluric 80 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. Caution should be exercised when Feluric 80 mg is administered to a nursing woman.
Precautions & Warnings
Gout Flare: An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents, including Feluric 80 mg. If a gout flare occurs during treatment, Feluric 80 mg need not be discontinued. Prophylactic therapy (i.e., non-steroidal anti-inflammatory drug (NSAID) or colchicine upon initiation of treatment) may be beneficial for up to six months.Cardiovascular Events: A higher rate of cardiovascular thromboembolic events was observed in patients treated with Feluric 80 mg than allopurinol in clinical trials. Monitor for signs and symptoms of MI and stroke.Liver Enzyme Elevation: Transaminase elevations have been observed in Feluric 80 mg -treated patients. Monitor liver function tests periodically.
Overdose Effects of Feluric 80 mg
Febustat was studied in healthy subjects in doses up to 300 mg daily for seven days without evidence of dose-limiting toxicities.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Use In Special Populations
Pediatric Use: Safety and effectiveness in pediatric patients under 18 years of age have not been established
Drug Classes
Drugs used in Gout
Mode Of Action
Feluric 80 mg is a non-purine, selective xanthine oxidase (XO) inhibitor. It decreases serum uric acid level by inhibiting xanthine oxidase, which is responsible for uric acid production. Xanthine oxidase breaks down hypoxanthine to xanthine and thus to uric acid. Feluric 80 mg is not expected to inhibit other enzymes involved in purine and pyrimidine synthesis and metabolism at therapeutic concentrations.
Pregnancy
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Feluric 80 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. Caution should be exercised when Feluric 80 mg is administered to a nursing woman.
Pediatric Uses
Pediatric Use: Safety and effectiveness in pediatric patients under 18 years of age have not been established
Frequently Asked Questions
What is Feluric 80 mg used for?
Febuxostat is indicated for the chronic management of hyperuricemia in patients with gout. Febuxostat is not recommended for the treatment of asymptomatic hyperuricemia.
What is the dosage of Feluric 80 mg?
Febuxostat is recommended at 40 mg or 80 mg once daily. The recommended starting dose of Febuxostat is 40 mg once daily. For patients who do not achieve a serum uric acid less than 6 mg /dL after 2 weeks with 40 mg, Febuxostat 80 mg is recommended. Febuxostat can be administered without regard to food or antacid use. No dose adjustment is necessary when administering Febuxostat to patients with mi…
What are the side effects of Feluric 80 mg?
The most common adverse events associated with the use of Febuxostat may include liver function abnormalities, nausea, arthralgia, and rash.
Who should not take Feluric 80 mg?
Febuxostat is contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline.
What precautions should be taken with Feluric 80 mg?
Gout Flare: An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents, including Febuxostat. If a gout flare occurs during treatment, Febuxostat need not be discontinued. Prophylactic therapy (i.e., non-steroidal anti-inflammatory drug (NSAID) or colchicine upon initiation of treatment) may be beneficial for up to six months.Cardiovascular Events: A higher ra…
Is Feluric 80 mg safe during pregnancy and breastfeeding?
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Febuxostat should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. Caution should be exercised when Febuxostat is administered to a nursing woman.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.