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Festam 2.5%

Festam 2.5%50 gm

Gel

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Medicine overview

Indications of Festam 2.5% 50 gm

Festam 2.5% 50 gm is indicated in musculoskeletal and joint disorders such as ankylosing spondylitisosteoarthritisand rheumatoid arthritisin periarticular disorders such as bursitis and tendinitisin mild to moderate pain such as dysmenorrhoea or postoperative painosteoarthritisankylosing spondylitisperiarticular conditions such as fibrositisbursitiscapsulitistendinitisand tenosynovitislow back pain of musculoskeletal originsciaticaother musculoskeletal conditionstendinitisedemabruises) and pain.

Theropeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Pharmacology

Festam 2.5% 50 gm is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic actions.

Absorption

Festam 2.5% 50 gm is rapidly and almost completely absorbed from the GI tract.

Distribution

It is approximately 99% bound to plasma protein, mainly albumin.

Metabolism

Following single or multiple oral doses in healthy adults, the elimination half-life of the drug has averaged 1.1-4 hours. It is rapidly and extensively metabolized in the liver, principally via conjugation with glucoronic acid. The elimination half-life is approximately 1.88 hour.

Excretion

Following single or multiple oral doses in healthy adults, the elimination half-life of the drug has averaged 1.1-4 hours. Following a single oral dose of Festam 2.5% 50 gm in healthy adults, about 50-90% of the drug is excreted in urine and about 1-8% in faeces within 1-5 days ; most urinary excretion occurs within 12-24 hours and most faecal excretion occurs within 24-48 hours. The elimination half-life is approximately 1.88 hour.

Dosage & Administration of Festam 2.5% 50 gm

Festam 2.5% 50 gm Tablet
Dosage:Oral treatment with Festam 2.5% 50 gm is 50-100 mg daily, taken with food to minimize gastrointestinal disturbance
Notes:For rheumatic disease, 100-200 mg daily in 2-4 divided doses with food. For pain and dysmenorrhoea, 50 mg up to 3 times daily
Festam 2.5% 50 gm SR Capsule
Dosage:100-200 mg once daily, depending on patient’s weight and on severity of symptomsFestam 2.5% 50 gm IM injection: Adults: 50 to 100 mg every four hours, repeated up to a maximum of 200 mg in twenty-four hours for up to 3 days
Notes:Following a satisfactory response oral therapy should be instituted with Festam 2.5% 50 gm tablet. It is recommended that the injection should not normally be continued for longer than three days
Elderly
Dosage:As with other medications it is generally advisable in the elderly to begin Festam 2.5% 50 gm therapy at the lower end of the dose range and to maintain such patients on the lowest effective dosage
Paediatric dosage
Dosage:Not established for intramuscular use
Notes:It is not used as intravenous injection
Festam 2.5% 50 gm 2.5% Gel
Dosage:This is to be applied to the painful area twice daily
Notes:The gel can be used with an occlusive dressing. Rub gently into the skin to ensure penetration
Suppository
Dosage:1 suppository (100 mg) late at night supplemented as required with Festam 2.5% 50 gm capsules during daytime
Notes:Festam 2.5% 50 gm suppositories are especially appropriate for controlling overnight symptoms (severity of night and morning pain; duration and severity of morning stiffness). Suppositories administered late at night provide more consistent effective control of overnight symptoms than oral medication. Dosage of Festam 2.5% 50 gm must be carefully adjusted according to individual requirements and response, using the lower possible effective dosage. Dosage exceeding 300 mg daily has not been adequately studied and are not recommended

Interaction of Festam 2.5% 50 gm

As Festam 2.5% 50 gm may cause GI bleeding, inhibit platelet aggregation and prolong bleeding time, the drug should be used with caution and the patient should be carefully observed if the drug is used concomitantly with any anticoagulant or thrombolytic agent. Concomitant administration of Festam 2.5% 50 gm and hydrochlorothiazide has resulted in decreased urinary excretion of potassium and chloride compared with hydrochlorothiazide alone. Festam 2.5% 50 gm and salicylates appear to interact in a complex manner and they should not be used concomitantly. Concomitant use of Festam 2.5% 50 gm and probenecid is also not recommended. Festam 2.5% 50 gm should be avoided in patients receiving methotrexate.

Contraindications

Festam 2.5% 50 gm is contraindicated in patients with known hypersensitivity to the drug. Festam 2.5% 50 gm is contraindicated in patients in whom asthma, urticaria, or other sensitivity reaction is precipitated by aspirins or other NSAIDs, since severe, rarely fatal, anaphylactic reactions to Festam 2.5% 50 gm have been reported in these patients. The risk of potentially serious adverse GI effects should be considered in patients receiving Festam 2.5% 50 gm, particularly in patients receiving chronic therapy with the drug. Festam 2.5% 50 gm should be used in patients with GI bleeding or active peptic ulceration only when the potential benefits justify the possible risks.

Side Effects of Festam 2.5% 50 gm

Adverse reactions to Festam 2.5% 50 gm are usually mild and mainly involve the GI tract, particularly upper GI tract. Most Festam 2.5% 50 gm-induced adverse effects occur during the first month of treatment, and the frequency of adverse effects generally decreases with continued therapy. Adverse reactions involving digestive system are dyspepsia, nausea, abdominal pain, diarrhoea, constipation, flatulence, anorexia, vomiting, stomatitis and that involving nervous system are headache, dizziness, malaise, depression, nervousness, dreams, etc. Other reactions are tinnitus, visual disturbance, rash, impairment of renal function, signs or symptoms of urinary-tract irritation.

Pregnancy & Lactation

Embryopathic effects have not been recorded with Festam 2.5% 50 gm, but it is recommended to avoid medication during pregnancy. Trace amounts of the drug appear in breast milk and it should not be used during breast feeding unless unavoidable.

Precautions & Warnings

Festam 2.5% 50 gm should be used with caution in patients who may be adversely affected by a prolongation of bleeding time (e.g. patients receiving anticoagulant therapy), since the drug may inhibit platelet function. Festam 2.5% 50 gm should be used with caution in patients with heart failure, hypertension, or other conditions associated with fluid retention, since peripheral edema has been observed in some patients receiving the drug. Liver function should be monitored periodically during long-term Festam 2.5% 50 gm therapy. Festam 2.5% 50 gm injection must not be given intravenously. Festam 2.5% 50 gm gel should not be applied to patients who have allergy to Festam 2.5% 50 gm, other anti-inflammatory agents and aspirin.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Use In Special Populations

For children: There is no contraindication to the use of this drug in children, but the appropriate dosage has not yet been established.

Frequently Asked Questions

What is Festam 2.5% 50 gm used for?

Ketoprofen is indicated in musculoskeletal and joint disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis, in periarticular disorders such as bursitis and tendinitis, in mild to moderate pain such as dysmenorrhoea or postoperative pain, and in other painful and inflammatory conditions such as acute gout or soft tissue disorders.Ketoprofen is used for symptomatic relie…

What is the dosage of Festam 2.5% 50 gm?

Ketoprofen Tablet: Oral treatment with Ketoprofen is 50-100 mg daily, taken with food to minimize gastrointestinal disturbance. For rheumatic disease, 100-200 mg daily in 2-4 divided doses with food. For pain and dysmenorrhoea, 50 mg up to 3 times daily.Ketoprofen SR Capsule: 100-200 mg once daily, depending on patient’s weight and on severity of symptomsKetoprofen IM injection: Adults: 50 to 100 …

What are the side effects of Festam 2.5% 50 gm?

Adverse reactions to Ketoprofen are usually mild and mainly involve the GI tract, particularly upper GI tract. Most Ketoprofen-induced adverse effects occur during the first month of treatment, and the frequency of adverse effects generally decreases with continued therapy. Adverse reactions involving digestive system are dyspepsia, nausea, abdominal pain, diarrhoea, constipation, flatulence, anor…

Who should not take Festam 2.5% 50 gm?

Ketoprofen is contraindicated in patients with known hypersensitivity to the drug. Ketoprofen is contraindicated in patients in whom asthma, urticaria, or other sensitivity reaction is precipitated by aspirins or other NSAIDs, since severe, rarely fatal, anaphylactic reactions to Ketoprofen have been reported in these patients. The risk of potentially serious adverse GI effects should be considere…

What precautions should be taken with Festam 2.5% 50 gm?

Ketoprofen should be used with caution in patients who may be adversely affected by a prolongation of bleeding time (e.g. patients receiving anticoagulant therapy), since the drug may inhibit platelet function. Ketoprofen should be used with caution in patients with heart failure, hypertension, or other conditions associated with fluid retention, since peripheral edema has been observed in some pa…

Is Festam 2.5% 50 gm safe during pregnancy and breastfeeding?

Embryopathic effects have not been recorded with Ketoprofen, but it is recommended to avoid medication during pregnancy. Trace amounts of the drug appear in breast milk and it should not be used during breast feeding unless unavoidable.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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