Granocyte34 MIU/vial

The drug is used to reduce the risk of life-threatening infection in patients with neutropenia, particularly after cytotoxic chemotherapy. Granocyte 34 MIU/vial is indicated as a treatment to reduce the duration of neutropenia and the severity of infections in patients with non-myeloid malignancy who have undergone ... Read moreThe drug is used to reduce the risk of life-threatening infection in patients with neutropenia, particularly after cytotoxic chemotherapy. Granocyte 34 MIU/vial is indicated as a treatment to reduce the duration of neutropenia and the severity of infections in patients with non-myeloid malignancy who have undergone autologous or allogeneic bone marrow transplantation, or treatment with established cytotoxic chemotherapy and in addition to reduce the incidence of infection associated with established cytotoxic chemotherapy. Granocyte 34 MIU/vial is also indicated to mobilise peripheral blood progenitor cells (PBPCs) with Granocyte 34 MIU/vial alone, or after myelosuppressive chemotherapy, in order to accelerate haematopoietic recovery by infusion of such cells, after myelosuppressive or myeloablative therapy. Granocyte 34 MIU/vial is also indicated to accelerate the engraftment of these cells after their reinfusion.

Granocyte 34 MIU/vial (rHuG-CSF) 13.4 million International Units (equivalent to 105 micrograms) per ml after reconstitution Granocyte 34 MIU/vial (rHuG-CSF) 33.6 million International Units (equivalent to 263 micrograms) per ml after reconstitution

Haematopoietic Agents

Granocyte 34 MIU/vial is the glycosylated recombinant form of human granulocyte colony stimulating factor. Granocyte 34 MIU/vial accelerates neutrophil recovery significantly after chemotherapy, with beneficial effects on clinical end-points such as incidence of laboratory-confirmed infection and length of hospital stay. Chemotherapy dose intensity has also been increased in patients receiving Granocyte 34 MIU/vial, notably those with breast or small cell lung cancer, although improvements in tumour response and survival have not been demonstrated. Granocyte 34 MIU/vial also assists neutrophil recovery in patients undergoing bone marrow transplantation, and stimulates the production of peripheral blood stem cells (PBSCs) for autologous transfusion after aggressive chemotherapy.

Intravenous-Neutropenia following bone marrow transplantation: Adult: 19.2 million IU/m2 or 150 mcg/m2 daily by IV infusion started the day after transplantation for a maximum of 28 consecutive days. Child: >2 yr: 19.2 million IU/m2 or 150 mcg/m2 daily by IV infusion started the day after transplantation for a maximum of 28 consecutive days. Subcutaneous-Mobilisation of peripheral blood progenitor cells for autologous peripheral blood stem cell transplantation: Adult: As monotherapy: 1.28 million IU/kg or 10 mcg/kg daily for 4-6 days (5-6 days in healthy donors). Following adjunctive myelosuppressive chemotherapy: 19.2 million IU/m2 or 150 mcg/m2 daily, started the day after completion of chemotherapy for a maximum of 28 consecutive days. Subcutaneous-Chemotherapy-induced neutropenia: Adult: 19.2 million IU/m2 or 150 mcg/m2 daily, start the day after completion of chemotherapy for a maximum of 28 consecutive days.

Intravenous-Neutropenia following bone marrow transplantation: Adult: 19.2 million IU/m2 or 150 mcg/m2 daily by IV infusion started the day after transplantation for a maximum of 28 consecutive days. Child: >2 yr: 19.2 million IU/m2 or 150 mcg/m2 daily by IV infusion started the day after transplantation for a maximum of 28 consecutive days. Subcutaneous-Mobilisation of peripheral blood progenitor cells for autologous peripheral blood stem cell transplantation: Adult: As monotherapy: 1.28 million IU/kg or 10 mcg/kg daily for 4-6 days (5-6 days in healthy donors). Following adjunctive myelosuppressive chemotherapy: 19.2 million IU/m2 or 150 mcg/m2 daily, started the day after completion of chemotherapy for a maximum of 28 consecutive days. Subcutaneous-Chemotherapy-induced neutropenia: Adult: 19.2 million IU/m2 or 150 mcg/m2 daily, start the day after completion of chemotherapy for a maximum of 28 consecutive days.

Increased risk of myelosuppression with myelosuppressive antineoplastic agents; increased pulmonary toxicity with bleomycin and cyclophosphamide.

Myeloid malignancies. Not to be used for 24 hr before or after cytotoxic chemotherapy.

Musculoskeletal pain, bone pain, splenic enlargement, nausea, fever, thrombocytopenia, anaemia, epistaxis, headache, diarrhoea, dysuria, osteoporosis, cutaneous vasculitis, anorexia, Sweet's syndrome, toxic epidermal necrolysis.

Pregnancy category is not classified.

Premalignant or malignant myeloid condition; sickle-cell disease; osteoporotic bone disease; signs of pulmonary infiltrates (withdraw treatment). Monitor CBC during therapy. Pregnancy and lactation.

Should be stored in cool and dry place

Haematopoietic Agents

Granocyte 34 MIU/vial is the glycosylated recombinant form of human granulocyte colony stimulating factor. Granocyte 34 MIU/vial accelerates neutrophil recovery significantly after chemotherapy, with beneficial effects on clinical end-points such as incidence of laboratory-confirmed infection and length of hospital stay. Chemotherapy dose intensity has also been increased in patients receiving Granocyte 34 MIU/vial, notably those with breast or small cell lung cancer, although improvements in tumour response and survival have not been demonstrated. Granocyte 34 MIU/vial also assists neutrophil recovery in patients undergoing bone marrow transplantation, and stimulates the production of peripheral blood stem cells (PBSCs) for autologous transfusion after aggressive chemotherapy.

Pregnancy category is not classified.