Hepaclin5 gm/10 ml
IV Injection
L-Ornithine L-Aspartate
Incepta Pharmaceuticals Ltd.
Product Code : 8170
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Medicine overview
Indications of Hepaclin 5 gm/10 ml
This is indicated for the treatment of Hepatic Encephalopathy, Acute Liver Failure, Hyperammonemia due to Acute and Chronic Hepatitis, Fatty Liver, Alcoholic Liver damage, Adjunct to hepatotoxic drugs, Liver Cirrhosis, Post hepatitis convalescence etc.
Theropeutic Class
Digestive Enzyme
Pharmacology
Hepaclin 5 gm/10 ml is a stable combination of two important endogenous Amino Acids, L-Ornithine and L-Aspartate. After administration, it quickly breaks down into L-Ornithine and L-Aspartate. L-Ornithine being a substrate of urea cycle, converts toxic ammonia into non-toxic urea which is eliminated via kidneys, helping the diseased liver to carry out its normal function smoothly (detoxification). The process lowers the elevated level of ammonia in blood (hyperammonemia) which is a common problem in most of the liver diseases. L-Aspartate is an essential component of citric acid cycle which liberates energy (ATP), and thus helps in regeneration of damaged liver cells.
Dosage of Hepaclin 5 gm/10 ml
Sachet: 1-2 sachets granules is dissolved in a large amount of fluid (e.g. in a glass of water or juice) and is taken orally 3 times a day during or after meals.Injection (Infusion Concentrate): The recommended dose is up to 20 gm (4 ampoules daily). In case of loss of consciousness (pre-coma) and clouding of consciousness (coma) up to 8 ampoules within 24 hours, depending on the severity of the condition.
Administration of Hepaclin 5 gm/10 ml
Hepaclin 5 gm/10 ml infusion concentrate can be added to any of the conventional intravenous fluids (0.9% Sodium Chloride, 5% Dextrose and Ringer's lactate etc.)
The normal dilution rate is 1 ampoule per 100 ml of I.V. fluid. However, the dose should not exceed 6 ampoules per 500 ml infusion. The solution mixtures were stable up to 24 hours.
Infusion Rate: 5 gm/h at maximum.
Interaction of Hepaclin 5 gm/10 ml
No data regarding the interactions of Hepaclin 5 gm/10 ml was found.
Side Effects of Hepaclin 5 gm/10 ml
Very rarely side effects like nausea and vomiting occur. These side effects are usually transient and do not necessitate the withdrawal of the drug.
Pregnancy & Lactation
The administration in pregnancy and lactation should be avoided.
Precautions & Warnings
Monitoring of serum and urinary urea levels at regular intervals should be done.
Storage Conditions
Store in a cool and dry place, keep away from light.
Drug Classes
Digestive Enzyme
Mode Of Action
Hepaclin 5 gm/10 ml is a stable combination of two important endogenous Amino Acids, L-Ornithine and L-Aspartate. After administration, it quickly breaks down into L-Ornithine and L-Aspartate. L-Ornithine being a substrate of urea cycle, converts toxic ammonia into non-toxic urea which is eliminated via kidneys, helping the diseased liver to carry out its normal function smoothly (detoxification). The process lowers the elevated level of ammonia in blood (hyperammonemia) which is a common problem in most of the liver diseases. L-Aspartate is an essential component of citric acid cycle which liberates energy (ATP), and thus helps in regeneration of damaged liver cells.
Pregnancy
The administration in pregnancy and lactation should be avoided.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.
