Herplex0.1%
Ophthalmic Solution
Idoxuridine
Opso Saline Ltd.
Product Code : 8199
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Medicine overview
Indications of Herplex 0.1%
Herplex 0.1% Eye drops is used for Skin infection, Eyes infection, Infection of reproduction organs, Herpes simplex infections of skin, External reproductive organs infection, External eyes area infection and other conditions. Herplex 0.1% Eye drops may also be used for purposes not listed in this medication guide.
Theropeutic Class
Ophthalmic Anti-viral Products
Pharmacology
Herpes simplex virus utilizes thymidine in the synthesis of deoxyribonucleic acid (DNA), a metabolite necessary for reproduction. Herplex 0.1% is identical in chemical structure to thymidine except that the 5-methyl group is replaced by iodine. When Herplex 0.1% is substituted for thymidine in DNA, the cell is unable to utilize the DNA and reproduction ceases.
Dosage & Administration of Herplex 0.1%
Herpes simplex keratitis: As 0.1% solution: Instill 1 drop in the affected eye(s) every hour. Taper to every 2 hr or 4 times daily. Continue treatment for at least 7 days.
Dosage of Herplex 0.1%
Herpes simplex keratitis: As 0.1% solution: Instill 1 drop in the affected eye(s) every hour. Taper to every 2 hr or 4 times daily. Continue treatment for at least 7 days.
Interaction of Herplex 0.1%
Corticosteroids may accelerate spread of viral infection.
Contraindications
Contraindicated in hypersensitivity to any ingredient of this preparation.
Side Effects of Herplex 0.1%
Common side effects are eye irritation or pain, redness, itching, swelling of the eye, increased sensitivity to light and glare
Pregnancy & Lactation
Herplex 0.1% should be administered with caution in pregnancy or in women of childbearing potential. Herplex 0.1% has been reported to cross the placental barrier and to produce fetal malformations in rabbits when administered topically to the eyes of pregnant females in doses similar to those used clinically.
Precautions & Warnings
For topical use only. Do not exceed the frequency or duration of recommended dosage. The incidence of some adverse reactions increases with prolonged use. Herplex 0.1% is not effective in corneal inflammations following herpes simplex keratitis in which the virus is not present. Some strains of herpes simplex appear resistant to the action of Herplex 0.1%.
Storage Conditions
Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children.
Drug Classes
Ophthalmic Anti-viral Products
Mode Of Action
Herpes simplex virus utilizes thymidine in the synthesis of deoxyribonucleic acid (DNA), a metabolite necessary for reproduction. Herplex 0.1% is identical in chemical structure to thymidine except that the 5-methyl group is replaced by iodine. When Herplex 0.1% is substituted for thymidine in DNA, the cell is unable to utilize the DNA and reproduction ceases.
Pregnancy
Herplex 0.1% should be administered with caution in pregnancy or in women of childbearing potential. Herplex 0.1% has been reported to cross the placental barrier and to produce fetal malformations in rabbits when administered topically to the eyes of pregnant females in doses similar to those used clinically.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.
