Hi-C100 ml

Hi-C 100 ml is a water-soluble vitamin and essential nutrient prescribed for the prevention and treatment of vitamin C deficiency, as well as a range of conditions where the body's requirement is increased. It is indicated in the following:

• Prevention and treatment of scurvy (vitamin C deficiency disease)
• Promotes healing of wounds, burns, fractures and broken bones
• Supports the formation of collagen in connective tissues, skin, blood vessels and cartilage
• Enhances iron absorption from the gastrointestinal tract and aids in the management of iron-deficiency anemia
• Contributes to the production of hemoglobin and red blood cells in the bone marrow
• Strengthens the immune system and helps protect against many viral and bacterial infections
• Assists in the prevention and treatment of the common cold
• Promotes healthy capillaries, gums and teeth
• Acts as an antioxidant, reducing cellular damage caused by free radicals and environmental pollutants

Hi-C 100 ml is also widely used as a daily dietary supplement to maintain overall health, particularly in individuals with poor dietary intake, increased physiological demand, smokers, and those recovering from illness or surgery.

Always take medicines according to the advice of a registered physician.

Hi-C 100 ml belongs to the therapeutic class of Vitamin-C Preparations.

Ascorbic Acid is an essential water-soluble vitamin that the human body cannot synthesize on its own; it must therefore be obtained through diet or supplementation. Once absorbed, it participates in numerous physiological processes vital for growth, repair and overall health.

Vitamin C is required for tissue growth and repair, normal adrenal gland function, healthy gums, and the maintenance of a robust immune system. As a powerful antioxidant, it neutralizes harmful free radicals and offers protection against oxidative stress caused by pollution and infection, thereby reducing cellular damage.

Acting as an essential coenzyme, ascorbic acid is a necessary factor in the biosynthesis of collagen, wound healing, drug metabolism, and the metabolism of cholesterol and folic acid. It also enhances the absorption of non-heme iron in the intestine, supporting the formation of hemoglobin and red blood cells.

As a key nutrient, Vitamin C supports healthy skin and hair, strengthens immunity and contributes to overall well-being. Being water-soluble, excess amounts are largely excreted in the urine, and the body maintains no significant long-term stores, making regular intake important.

Potentially Hazardous Interactions

Ascorbic acid is chemically incompatible in solution with the following agents, and should not be mixed with them:

• Aminophylline
• Bleomycin
• Erythromycin lactobionate
• Nafcillin
• Nitrofurantoin sodium
• Conjugated oestrogens
• Sodium bicarbonate
• Sulphafurazole diethanolamine
• Chloramphenicol sodium succinate
• Chlorothiazide sodium
• Hydrocortisone sodium succinate

Useful Interactions

Ascorbic acid increases the apparent half-life of paracetamol and enhances the absorption of iron from the gastrointestinal tract, making it a useful adjunct in the management of iron-deficiency states.

Hi-C 100 ml has very low toxicity and is generally well tolerated at normal doses. Adverse effects are uncommon and are mostly associated with mega-doses. Reported side effects include:

• Diarrhoea and abdominal bloating
• Excessive iron absorption, which may be harmful in patients with thalassaemia, sideroblastic anemia and haemochromatosis
• Hyperoxaluria (increased urinary oxalate), raising the risk of kidney stones
• Hyperuricosuria (increased urinary uric acid)
• Haemolysis in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency
• In pregnant women, intake exceeding 5 g/day may increase the risk of fetal abortion

Most of these effects resolve on reducing the dose. Patients should seek medical advice if any troublesome or persistent symptoms occur.

Pregnancy: Hi-C 100 ml is considered safe when taken at normal recommended doses during pregnancy. However, a daily intake of 5 g or more has been reported to cause abortion and should be strictly avoided. Regular mega-dosing during pregnancy has also been linked to rebound scurvy in newborns.

Lactation: Ascorbic Acid may be taken safely during breastfeeding at normal doses. As with any supplement, pregnant and lactating women should use Vitamin C only under the guidance of a registered physician and avoid excessive intake.

The following precautions should be observed when using Hi-C 100 ml:

• Ingestion of mega-doses (more than 1000 mg daily) during pregnancy has resulted in scurvy in neonates due to a rebound effect; such high doses should be avoided.
• Vitamin C in mega-doses is contraindicated in patients with hyperoxaluria because of the increased risk of oxalate stone formation.
• Ascorbic acid is a reactive substance in the redox system and can cause false-positive or false-negative results in certain laboratory tests, including those for blood glucose, uric acid, creatinine and occult blood. Patients should inform their physician or laboratory of any Vitamin C use before testing.
• Caution is advised in patients with a history of kidney stones, renal impairment, or iron-overload disorders.

Because Hi-C 100 ml is water-soluble, excess amounts are usually excreted in the urine, and serious toxicity from overdose is rare. However, ingestion of very large doses (mega-doses) may lead to:

• Gastrointestinal disturbances such as diarrhoea, nausea and abdominal bloating
• Increased urinary oxalate (hyperoxaluria), raising the risk of kidney stone formation
• Increased urinary uric acid (hyperuricosuria)
• Excessive iron absorption in susceptible individuals
• Haemolysis in patients with G6PD deficiency

Management of overdose is generally supportive, including discontinuation of the supplement, adequate hydration and symptomatic treatment. In case of a suspected significant overdose, medical advice should be sought promptly.

Store in a cool, dry place, protected from light, at a temperature below 30°C. Keep the container tightly closed. Keep all medicines out of the reach and sight of children.

Elderly: Vitamin C is well tolerated in older adults and may be used at 1–2 tablets daily, including for reduction of stroke risk. Dietary intake is often inadequate in this group, making supplementation beneficial.

Children: Ascorbic Acid is used for the prevention and treatment of scurvy in children, with the dose adjusted according to age, body weight and the severity of deficiency, as directed by a physician. Syrup and chewable formulations are suitable for paediatric use.

Patients with G6PD deficiency: High doses should be avoided due to the risk of haemolysis.

Patients with renal impairment or kidney stones: High-dose Vitamin C should be used with caution because of the risk of oxalate stone formation and hyperoxaluria.

Patients with iron-overload disorders: Those with thalassaemia, haemochromatosis or sideroblastic anemia should avoid mega-doses due to enhanced iron absorption.

Vitamin-C Preparations

This is a preparation of Ascorbic Acid (Vitamin C). Ascorbic Acid is an essential nutrient, which means it cannot be produced by the body and therefore must be obtained from diet or supplements. Ascorbic Acid has many important functions. It is required for tissue growth & repair, Adrenal gland function, enhanced immunity & healthy gums. As an antioxidant, it gives protection against harmful pollution, infection & reduces cellular damage. As a coenzyme, it is a necessary factor for wound healing, drug metabolism & metabolism of cholesterol & folic acid. As an essential nutrient, vitamin C supports healthy hair & skin, strengthens the immune system and maintain overall good health.

The drug is safe in normal doses in pregnant women, but a daily intake of 5 gm or more is reported to have caused abortion. The drug may be taken safely during lactation.