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Hi-Flow

Hi-Flow0.4 mg

Capsule (Modified Release)

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Medicine overview

Indications of Hi-Flow 0.4 mg

Hi-Flow 0.4 mg is indicated for the treatment of the signs and symptoms of Benign Prostatic Hyperplasia (BPH).

Theropeutic Class

BPH/ Urinary retention/ Urinary incontinence

Pharmacology

Tamsulosin is an antagonist of α1A-adrenoreceptors in the prostate.

Absorption

It binds selectively and competitively to postsynaptic α1A-adrenoreceptors, which convey smooth muscle contraction, thereby relaxing prostatic and urethral smooth muscle.

Dosage & Administration of Hi-Flow 0.4 mg

The recommended dose of Tamsulosin is 0.4 mg once daily. It should be administered approximately half/hour following the same meal each day. For those patients who fail to respond to the 0.4 mg dose after two to four weeks of dosing, the dose of Tamsulosin can be increased to 0.8mg once daily. If Tamsulosin administration is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, therapy should be started again with the 0.4 mg once daily dose.

Interaction of Hi-Flow 0.4 mg

Increased plasma concentration with strong CYP3A4 inhibitors (e.g. ketoconazole). Moderate CYP3A4 inhibitors (e.g. erythromycin), strong (e.g. paroxetine) or moderate (e.g. terbinafine) CYP2D6 inhibitors may increase exposure of tamsulosin. Increased plasma concentration with cimetidine. Additive effect with other α-adrenergic blocking agents. Concomitant use with PDE5 inhibitors may lead to symptomatic hypotension. Decreased plasma concentration with furosemide.

Contraindications

History of orthostatic hypotension. Severe hepatic impairment.

Side Effects of Hi-Flow 0.4 mg

The following adverse reactions have been reported during the use of Tamsulosin: dizziness, abnormal ejaculation, and less frequently (1-2%) headache, asthenia, postural hypotension, palpitations, and rhinitis.Gastrointestinal reactions such as nausea, vomiting, diarrhoea, and constipation can occasionally occur. Hypersensitivity reactions such as rash, pruritus, and urticaria can occur occasionally. As with other alpha-blockers, drowsiness, blurred vision, dry mouth, or edema can occur. Syncope has been reported rarely, and there have been very rare reports of angioedema and priapism.

Pregnancy & Lactation

Hi-Flow 0.4 mg capsules are not indicated for use in women.

Precautions & Warnings

Not indicated for use in women. Severe renal impairment (CrCl <10 mL/min). Pregnancy and lactation.

Overdose Effects of Hi-Flow 0.4 mg

As overdose of Hi-Flow 0.4 mg capsules lead to hypotension, support the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in supine position. If this measure is inadequate, then administration of intravenous fuid should be considered. Measures, such as emesis, can be taken to impede absorption. When large quantities are involved, gastric lavage can be applied and activated charcoal and an osmotic laxative, such as sodium sulphate, can be administered.

Storage Conditions

Store between 20-25° C.

Use In Special Populations

Hi-Flow 0.4 mg capsules are not indicated for use in pediatric populations.

Frequently Asked Questions

What is Hi-Flow 0.4 mg used for?

Tamsulosin Hydrochloride is indicated for the treatment of the signs and symptoms of Benign Prostatic Hyperplasia (BPH).

What is the dosage of Hi-Flow 0.4 mg?

The recommended dose of Tamsulosin is 0.4 mg once daily. It should be administered approximately half/hour following the same meal each day. For those patients who fail to respond to the 0.4 mg dose after two to four weeks of dosing, the dose of Tamsulosin can be increased to 0.8mg once daily. If Tamsulosin administration is discontinued or interrupted for several days at either the 0.4 mg or 0.8 …

What are the side effects of Hi-Flow 0.4 mg?

The following adverse reactions have been reported during the use of Tamsulosin: dizziness, abnormal ejaculation, and less frequently (1-2%) headache, asthenia, postural hypotension, palpitations, and rhinitis.Gastrointestinal reactions such as nausea, vomiting, diarrhoea, and constipation can occasionally occur. Hypersensitivity reactions such as rash, pruritus, and urticaria can occur occasional…

Who should not take Hi-Flow 0.4 mg?

History of orthostatic hypotension. Severe hepatic impairment.

What precautions should be taken with Hi-Flow 0.4 mg?

Not indicated for use in women. Severe renal impairment (CrCl <10 mL/min). Pregnancy and lactation.

Is Hi-Flow 0.4 mg safe during pregnancy and breastfeeding?

Tamsulosin Hydrochloride capsules are not indicated for use in women.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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