Humalog Cartridge100 unit/ml

Humalog Cartridge 100 unit/ml is an insulin analogue that is indicated in the treatment of patients with diabetes mellitus for the control of hyperglycemia. Humalog Cartridge 100 unit/ml has a more rapid onset and a shorter duration of action than human regular insulin. Therefore, in patients with type 1 diabetes, Humalog Cartridge 100 unit/ml ... Read moreHumalog Cartridge 100 unit/ml is an insulin analogue that is indicated in the treatment of patients with diabetes mellitus for the control of hyperglycemia. Humalog Cartridge 100 unit/ml has a more rapid onset and a shorter duration of action than human regular insulin. Therefore, in patients with type 1 diabetes, Humalog Cartridge 100 unit/ml should be used in regimens that include a longer-acting insulin. However, in patients with type 2 diabetes, Humalog Cartridge 100 unit/ml may be used without a longer-acting insulin when used in combination therapy with sulfonylurea agents.

Rapid Acting Insulin

Humalog Cartridge 100 unit/ml (Humalog Cartridge 100 unit/ml, rDNA origin) is a human insulin analogue that is a rapid-acting, parenteral blood glucose-lowering agent. Chemically, it is Lys(B28), Pro(B29) human insulin analogue, created when the amino acids at positions 28 and 29 on the insulin B -chain are reversed. Humalog Cartridge 100 unit/ml is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for Humalog Cartridge 100 unit/ml. The blood glucose lowering effect of Humalog Cartridge 100 unit/ml is due to the facilitated uptake of glucose following binding of insulin to receptors on muscle and fat cells and to the simultaneous inhibition of glucose output from the liver.

Adult: SC Dosing regimen should be individualised and adjusted based on patient's glycaemic response. Usual range is 0.5-1 unit/kg/day.Type 1 diabetes mellitus: Approximately one third of the total daily insulin requirements SC; rapid-acting or short-acting, premeal insulin should be used to satisfy the remainder of the daily insulin requirementsUsual daily maintenance range: 0.5-1 unit/kg/day in divided doses; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.8-1.2 units/kg/dayType 2 diabetes mellitus: If inadequately controlled with oral medication: 10 units/day SC (or 0.1 -0.2 unit/kg/day) of intermediate- or long-acting insulin given at bedtime generally recommended; as an alternative, rapid-acting formulations, such as Humalog Cartridge 100 unit/ml, given before meals have also been used; dose must be adjusted carefully.

Adult: SC Dosing regimen should be individualised and adjusted based on patient's glycaemic response. Usual range is 0.5-1 unit/kg/day.Type 1 diabetes mellitus: Approximately one third of the total daily insulin requirements SC; rapid-acting or short-acting, premeal insulin should be used to satisfy the remainder of the daily insulin requirementsUsual daily maintenance range: 0.5-1 unit/kg/day in divided doses; nonobese may require 0.4-0.6 unit/kg/day; obese may require 0.8-1.2 units/kg/dayType 2 diabetes mellitus: If inadequately controlled with oral medication: 10 units/day SC (or 0.1 -0.2 unit/kg/day) of intermediate- or long-acting insulin given at bedtime generally recommended; as an alternative, rapid-acting formulations, such as Humalog Cartridge 100 unit/ml, given before meals have also been used; dose must be adjusted carefully.

Insulin requirements may be increased by medications with hyperglycemic activity such as corticosteroids, isoniazid, certain lipid-lowering drugs (e.g., niacin), estrogens, oral contraceptives, phenothiazines, and thyroid replacement therapy. Insulin requirements may be decreased in the presence of drugs that increase insulin sensitivity or have hypoglycemic activity, such as oral antidiabetic agents, salicylates, sulfa antibiotics, certain antidepressants (monoamine oxidase inhibitors), angiotensin-converting-enzyme inhibitors, Angiotensin II receptor blocking agents, beta-adrenergic blockers, inhibitors of pancreatic function (e.g., octreotide), and alcohol. Beta-adrenergic blockers may mask the symptoms of hypoglycemia in some patients.

Humalog Cartridge 100 unit/ml is contraindicated by patients hypersensitivity to Humalog Cartridge 100 unit/ml or the other excipients.

Clinical studies comparing Humalog Cartridge 100 unit/ml with Regular human insulin did not demonstrate a difference in frequency of adverse events between the two treatments. Adverse events commonly associated with human insulin therapy include the following: Body as a Whole: allergic reactions. Skin and Appendages: injection site reaction, lipodystrophy, pruritus, rash. Other: hypoglycemia.

Pregnancy Category B. All pregnancies have a background risk of birth defects, loss, or other adverse outcome regardless of drug exposure. This background risk is increased in pregnancies complicated by hyperglycemia and may be decreased with good metabolic control. It is essential for patients with diabetes or history of gestational diabetes to maintain good metabolic control before conception and throughout pregnancy. In patients with diabetes or gestational diabetes insulin requirements may decrease during the first trimester, generally increase during the second and third trimesters, and rapidly decline after delivery. Careful monitoring of glucose control is essential in these patients. Therefore, female patients should be advised to tell their physicians if they intend to become, or if they become pregnant while taking Humalog Cartridge 100 unit/ml.Nursing Mothers: It is unknown whether Humalog Cartridge 100 unit/ml is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Humalog Cartridge 100 unit/ml is administered to a nursing woman. Use of Humalog Cartridge 100 unit/ml is compatible with breastfeeding, but women with diabetes who are lactating may require adjustments of their insulin doses.

Renal or hepatic impairment; pregnancy, lactation; transferring from other insulin. Monitor serum glucose, potassium, electrolytes, HbA1c and lipid profile. Concomitant illness esp infections.

Excess insulin administration may cause hypoglycemia and hypokalemia. Mild episodes of hypoglycemia usually can be treated with oral glucose. Adjustments in drug dosage, meal patterns, or exercise may be needed. More severe episodes with coma, seizure, or neurologic impairment may be treated with intramuscular/subcutaneous glucagon or concentrated intravenous glucose. Sustained carbohydrate intake and observation may be necessary because hypoglycemia may recur after apparent clinical recovery. Hypokalemia must be corrected appropriately.

Store at 2°C - 8°C in a refrigerator. Do not freeze. In case of insulin for recent use need not be refrigerated, try to keep it in a cool place and keep away from heat and light. The insulin in use can be kept under the room temperature for a month.

Pediatric Use: Humalog Cartridge 100 unit/ml is approved for use in children for subcutaneous daily injections. Only the U-100 formulation of Humalog Cartridge 100 unit/ml is approved for use in children by continuous subcutaneous infusion in insulin pumps. Humalog Cartridge 100 unit/ml has not been studied in pediatric patients younger than 3 years of age. Humalog Cartridge 100 unit/ml has not been studied in pediatric patients with type 2 diabetes. As in adults, the dosage of Humalog Cartridge 100 unit/ml must be individualized in pediatric patients based on metabolic needs and results of frequent monitoring of blood glucose.Geriatric Use: Of the total number of subjects (n=2834) in eight clinical studies of Humalog Cartridge 100 unit/ml, twelve percent (n=338) were 65 years of age or over. The majority of these had type 2 diabetes. HbA1c values and hypoglycemia rates did not differ by age. Pharmacokinetic/pharmacodynamic studies to assess the effect of age on the onset of Humalog Cartridge 100 unit/ml action have not been performed.Renal Impairment: Patients with renal impairment may be at increased risk of hypoglycemia and may require more frequent Humalog Cartridge 100 unit/ml dose adjustment and more frequent blood glucose monitoring.Hepatic Impairment: Patients with hepatic impairment may be at increased risk of hypoglycemia and may require more frequent Humalog Cartridge 100 unit/ml dose adjustment and more frequent blood glucose monitoring

Rapid Acting Insulin

Humalog Cartridge 100 unit/ml (Humalog Cartridge 100 unit/ml, rDNA origin) is a human insulin analogue that is a rapid-acting, parenteral blood glucose-lowering agent. Chemically, it is Lys(B28), Pro(B29) human insulin analogue, created when the amino acids at positions 28 and 29 on the insulin B -chain are reversed. Humalog Cartridge 100 unit/ml is synthesized in a special non-pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for Humalog Cartridge 100 unit/ml. The blood glucose lowering effect of Humalog Cartridge 100 unit/ml is due to the facilitated uptake of glucose following binding of insulin to receptors on muscle and fat cells and to the simultaneous inhibition of glucose output from the liver.

Pregnancy Category B. All pregnancies have a background risk of birth defects, loss, or other adverse outcome regardless of drug exposure. This background risk is increased in pregnancies complicated by hyperglycemia and may be decreased with good metabolic control. It is essential for patients with diabetes or history of gestational diabetes to maintain good metabolic control before conception and throughout pregnancy. In patients with diabetes or gestational diabetes insulin requirements may decrease during the first trimester, generally increase during the second and third trimesters, and rapidly decline after delivery. Careful monitoring of glucose control is essential in these patients. Therefore, female patients should be advised to tell their physicians if they intend to become, or if they become pregnant while taking Humalog Cartridge 100 unit/ml.Nursing Mothers: It is unknown whether Humalog Cartridge 100 unit/ml is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Humalog Cartridge 100 unit/ml is administered to a nursing woman. Use of Humalog Cartridge 100 unit/ml is compatible with breastfeeding, but women with diabetes who are lactating may require adjustments of their insulin doses.

Pediatric Use: Humalog Cartridge 100 unit/ml is approved for use in children for subcutaneous daily injections. Only the U-100 formulation of Humalog Cartridge 100 unit/ml is approved for use in children by continuous subcutaneous infusion in insulin pumps. Humalog Cartridge 100 unit/ml has not been studied in pediatric patients younger than 3 years of age. Humalog Cartridge 100 unit/ml has not been studied in pediatric patients with type 2 diabetes. As in adults, the dosage of Humalog Cartridge 100 unit/ml must be individualized in pediatric patients based on metabolic needs and results of frequent monitoring of blood glucose.Geriatric Use: Of the total number of subjects (n=2834) in eight clinical studies of Humalog Cartridge 100 unit/ml, twelve percent (n=338) were 65 years of age or over. The majority of these had type 2 diabetes. HbA1c values and hypoglycemia rates did not differ by age. Pharmacokinetic/pharmacodynamic studies to assess the effect of age on the onset of Humalog Cartridge 100 unit/ml action have not been performed.Renal Impairment: Patients with renal impairment may be at increased risk of hypoglycemia and may require more frequent Humalog Cartridge 100 unit/ml dose adjustment and more frequent blood glucose monitoring.Hepatic Impairment: Patients with hepatic impairment may be at increased risk of hypoglycemia and may require more frequent Humalog Cartridge 100 unit/ml dose adjustment and more frequent blood glucose monitoring