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Inbuten

Inbuten60 ml

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Medicine overview

Indications of Inbuten 60 ml

Moraxella catarrhalis (including (β-lactamase producing strains)Moraxella catarrhalis (including (β-lactamase producing strains)

Theropeutic Class

Third generation Cephalosporins

Pharmacology

As with most beta-lactam antibiotics, the bactericidal activity of ceftibuten results from the inhibition of bacterial cell wall synthesis.

Absorption

Due to its chemical structure, ceftibuten is highly stable to beta-lactamases.

Distribution

Many beta-lactamase-producing microorganisms, which are resistant to penicillins or other cephalosporins, may be inhibited by ceftibuten.

Dosage & Administration of Inbuten 60 ml

Notes:As with other oral antibiotics, duration of treatment generally ranges from 5-10 days. For treatment of infections due to Streptococcus pyogenes, a therapeutic dose of Ceftibuten should be administered for at least 10 days
Adults
Dosage:Recommended Dose: 400 mg daily
Notes:Ceftibuten capsules may be taken without regard to mealtime. For treatment in the following indications, this may be administered as 400 mg once daily: Acute bacterial sinusitis, acute bronchitis, acute exacerbations of chronic bronchitis, and complicated or uncomplicated urinary tract infections. For the treatment of community-acquired pneumonia in patients in whom oral therapy is appropriate, the recommended dose is 200 mg every 12 hrs
Children
Dosage:Recommended Dose: 9 mg/kg/day (maximum of 400 mg daily) of the oral suspension
Notes:This may be administered as a single daily dose for treatment in the following indications: Pharyngitis with or without tonsillitis, acute otitis media with effusion and complicated or uncomplicated urinary tract infections. For the treatment of acute bacterial enteritis in children, the total daily dosage may be administered in 2 divided doses of 4.5 mg/kg every 12 hrs. Children weighing >45 kg or >10 years may receive the recommended adult dose. Ceftibuten suspension may be taken approximately 1 or 2 hrs before or after mealtime. Shake bottle well before measuring each dose

Dosage of Inbuten 60 ml

Otitis Media- Adult Dosage
Dosage:400 mg orally every 24 hours for 10 days Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days Tonsillitis/Pharyngitis- Adult Dosage: 400 mg orally every 24 hours for 10 days Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days Bronchitis- Adult Dosage: 400 mg orally every 24 hours for 10 days Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 days Cystitis- Adult Dosage: 400 mg orally every 24 hours for 7 days Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 7 days Pneumonia- Adult Dosage: 200 mg orally every 12 hours for 7 to 14 days Pediatric Dosage: >12 years: 200 mg orally every 12 hours for 7 to 14 days Sinusitis- Adult Dosage: 400 mg orally every 24 hours for 10 to 14 days Pediatric Dosage: >12 years: 400 mg orally every 24 hours for 10 to 14 days Urinary tract Infection- Adult Dosage: 400 mg orally every 24 hours for 10 days Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days

Interaction of Inbuten 60 ml

Theophylline & Antacid do not alter the pharmacokinetic profile of Ceftibuten. Ranitidine increases the Cmax & AUC of Ceftibuten.

Contraindications

Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Side Effects of Inbuten 60 ml

Nausea, headache, diarrhea, dyspepsia, dizziness, abdominal pain, vomiting.

Pregnancy & Lactation

Ceftibuten has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Ceftibuten should be only given during pregnancy when need has been clearly established.Ceftibuten is acceptable to use during breastfeeding. Limited information indicates that single maternal doses of ceftibuten up to 200 mg produce low levels in milk that are not expected to cause adverse effects in breastfed infants.

Precautions & Warnings

As with other broad-spectrum antibiotics, prolonged treatment may result in the possible emergence and overgrowth of resistant organisms. Careful observation of the patient is essential. The dose of Ceftibuten may require adjustment in patients with varying degrees of renal insufficiency. Ceftibuten should be prescribed with caution to individuals with a history of gastrointestinal disease, particularly colitis.

Overdose Effects of Inbuten 60 ml

Overdose symptoms may include seizure (convulsions).

Storage Conditions

Store below 25°C, protected from light and moisture. For Suspension: After reconstitution, the suspension may be used for 14 days while stored at 2° to 8°C. Keep out of reach of children.

Use In Special Populations

Use in children: Safety and efficacy of Ceftibuten in infants <6 months have not been established.Adult Patients with Renal Impairment: Ceftibuten pharmacokinetics are not affected sufficiently to require dosage modifications unless creatinine clearance values are <50 mL/min. If creatinine clearance is from 49 to 30 mL/min, the daily dose should be decreased to 200 mg. With creatinine clearance values of 29 to 5 mL/min, the recommended daily dose is 100 mg.If alteration of dosing frequency is preferred, a 400-mg dose of Ceftibuten may be administered every 48 hrs (every 2 days) to a patient with a creatinine clearance of 30-49 mL/min, and every 96 hrs (every 4 days) if creatinine clearance is 5-29 mL/min.In patients undergoing hemodialysis 2 or 3 times weekly, a single dose of Ceftibuten 400 mg may be administered at the end of each hemodialysis session.

Drug Classes

Third generation Cephalosporins

Mode Of Action

Ceftibuten is the dihydrate salt of Ceftibuten, is a semi-synthetic Cephalosporin antibiotic for oral administration. Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis.

Pregnancy

Pregnancy Category B. There are no controlled data on the use of Ceftibuten in pregnant women. Ceftibuten should be used in pregnancy only when the benefit clearly outweighs the risk. It is not known whether Ceftibuten (recommended dosage) is excreted in human milk. Because many drugs are excreted in human milk, caution should be excercised when Ceftibuten is administered to nursing women.

Pediatric Uses

Renal Impairment- CrCl 5 to 29 ml/min: 2.25 mg/kg or 100 mg orally once a day CrCl 30 to 49 ml/min: 4.5 mg/kg or 200 mg orally once a day Hepatic Impairment: Dose adjustment is not necessary.

Frequently Asked Questions

What is Inbuten 60 ml used for?

Ceftibuten is indicated for the treatment of individuals with mild-to-moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Acute Bacterial Exacerbations of Chronic Bronchitis: Due to Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis (including (β-lactamase producing strains), or Streptococc…

What is the dosage of Inbuten 60 ml?

Otitis Media- Adult Dosage: 400 mg orally every 24 hours for 10 days Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days Tonsillitis/Pharyngitis- Adult Dosage: 400 mg orally every 24 hours for 10 days Pediatric Dosage: >6 months: 9 mg/kg/day (maximum 400 mg) every 24 hours for 10 days Bronchitis- Adult Dosage: 400 mg orally every 24 hours for 10 days Pediatric Dosa…

What are the side effects of Inbuten 60 ml?

Nausea, headache, diarrhea, dyspepsia, dizziness, abdominal pain, vomiting.

Who should not take Inbuten 60 ml?

Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

What precautions should be taken with Inbuten 60 ml?

As with other broad-spectrum antibiotics, prolonged treatment may result in the possible emergence and overgrowth of resistant organisms. Careful observation of the patient is essential. The dose of Ceftibuten may require adjustment in patients with varying degrees of renal insufficiency. Ceftibuten should be prescribed with caution to individuals with a history of gastrointestinal disease, partic…

Is Inbuten 60 ml safe during pregnancy and breastfeeding?

Ceftibuten has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Ceftibuten should be only given during pregnancy when need has been clearly established.Ceftibuten is acceptable to use during breastfeeding. Limited information indicates that single maternal doses of ceftibuten up to 200 mg…

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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