Kacin

Kacin500 mg/2 ml

IM/IV Injection

Amikacin

ACI Limited

Product Code : 8879
MRP 48.32
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Medicine overview

Indications of Kacin 500 mg/2 ml

Kacin 500 mg/2 ml is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. Kacin 500 mg/2 ml is effective in bacterial septicemia (including neonatal sepsis); in serious infections of the respiratory tract, bones and joints, central nervous system (including ... Read moreKacin 500 mg/2 ml is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria. Kacin 500 mg/2 ml is effective in bacterial septicemia (including neonatal sepsis); in serious infections of the respiratory tract, bones and joints, central nervous system (including meningitis) and skin and soft tissue; intra-abdominal infections (including peritonitis); and in burns and postoperative infections (including postvascular surgery). Clinical studies have shown Kacin 500 mg/2 ml also to be effective in serious complicated and recurrent urinary tract infections due to those organisms.Kacin 500 mg/2 ml was effective in infections caused by gentamicin and/or tobramycin-resistant strains of Gram-negative organisms, particularly Proteus rettgeri, Providencia stuartii, Serratia marcescens, and Pseudomonas aeruginosa.Kacin 500 mg/2 ml has also been shown to be effective in staphylococci infections and may be considered as initial therapy under certain conditions in the treatment of known or suspected staphylococcal disease such as, severe infections where the causative organism may be either a Gram-negative bacterium or a staphylococcus.

Theropeutic Class

Aminoglycosides

Pharmacology

Kacin 500 mg/2 ml Sulfate is a semi-synthetic aminoglycoside antibiotic. Kacin 500 mg/2 ml is active in vitro against pseudomonas species, Escherichia coli, Proteus species, Providencia species, Klebsiella-Enterobacter species, Acinetobacter species, and Citrobacter freundii. When strains of the above organisms are found to be resistant to other aminoglycosides, including Gentamicin, TobrAmykin and KanAmykin, many are susceptible to Kacin 500 mg/2 ml. Kacin 500 mg/2 ml sulfate is active in vitro against penicillinase and nonpenicillinase-producing Staphylococcus species including methicillin-resistant strains.

Dosage of Kacin 500 mg/2 ml

Adults and children: 15 mg/kg/day in two equally-divided doses (equivalent to 500 mg bid in adults). Use of the 100 mg is recommended for children for the accurate measurement of the appropriate dose.Neonates and premature children: An initial loading dose of 10 mg/kg followed by 15 mg/kg/day in two equally divided doses.Elderly: Kacin 500 mg/2 ml is excreted by the renal route. Renal function should be assessed whenever possible and dosage adjusted as described under impaired renal function.Life-threatening infections and/or those caused by Pseudomonas: The adult dose may be increased to 500 mg every eight hours but should neither exceed 1.5g/day nor be administered for a period longer than 10 days. A maximum total adult dose of 15g should not be exceeded.Urinary tract infections (other than pseudomonal infections): 7.5mg/kg/day in two equally divided doses (equivalent to 250 mg b.i.d. in adults).Impaired renal function: In patients with impaired renal function, the daily dose should be reduced and/or the intervals between doses increased to avoid accumulation of the drug.

Administration of Kacin 500 mg/2 ml

Intramuscular or intravenous administration: For most infections the intramuscular route is preferred, but in life threatening infections, or in patients in whom intramuscular injection route is not feasible the intravenous route may be used.Intraperitoneal use: Kacin 500 mg/2 ml may be used as an irrigant after recovery from anesthesia in concentration of 0.25%.

Interaction of Kacin 500 mg/2 ml

Concurrent administration of Kacin 500 mg/2 ml with myorelaxants leads to potentiation of their effects and there is a possibility of cessation of the breathing. The combination with other Aminoglycoside antibiotics should be avoided because of the augmentation of their ototoxic and nephrotoxic effects. Concurrent administration of Kacin 500 mg/2 ml with fast acting diuretics increases the risk of ototoxicity in patients with renal failure. Combination with Cephalosporins or Polymixins increases the risk of nephrotoxicity.

Contraindications

Kacin 500 mg/2 ml Injection is contraindicated in patients with a known history of hypersensitivity to Kacin 500 mg/2 ml, any constituents of the injection.

Side Effects of Kacin 500 mg/2 ml

The adverse effects have been reported with the use of Kacin 500 mg/2 ml are tinnitus, vertigo, partial reversible or irreversible deafness, skin rash, drug fever, headache, paraesthesia, nausea and vomiting.

Pregnancy & Lactation

Kacin 500 mg/2 ml rapidly crosses the placenta into the foetal circulation and amniotic fluid and there is a potential risk of ototoxicity in the foetus. There is no information available regarding the safety of this drug during breastfeeding.

Precautions & Warnings

Since Kacin 500 mg/2 ml is present in high concentrations in the renal excretory system, patients should be well hydrated to minimize chemical irritation of the renal tubules. If azotemia increases, treatment should be stopped. Monitoring of renal function during treatment with aminoglycosides is particularly important.

Overdose Effects of Kacin 500 mg/2 ml

In the event of overdose or toxic reaction, peritoneal dialysis or haemodialysis will aid in the removal of Kacin 500 mg/2 ml from the blood.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Use In Special Populations

Pediatric Use: Safety and effectiveness of Kacin 500 mg/2 ml for injection in children or adolescents under 16 years have not been established

Drug Classes

Aminoglycosides

Mode Of Action

Kacin 500 mg/2 ml Sulfate is a semi-synthetic aminoglycoside antibiotic. Kacin 500 mg/2 ml is active in vitro against pseudomonas species, Escherichia coli, Proteus species, Providencia species, Klebsiella-Enterobacter species, Acinetobacter species, and Citrobacter freundii. When strains of the above organisms are found to be resistant to other aminoglycosides, including Gentamicin, TobrAmykin and KanAmykin, many are susceptible to Kacin 500 mg/2 ml. Kacin 500 mg/2 ml sulfate is active in vitro against penicillinase and nonpenicillinase-producing Staphylococcus species including methicillin-resistant strains.

Pregnancy

Kacin 500 mg/2 ml rapidly crosses the placenta into the foetal circulation and amniotic fluid and there is a potential risk of ototoxicity in the foetus. There is no information available regarding the safety of this drug during breastfeeding.

Pediatric Uses

Pediatric Use: Safety and effectiveness of Kacin 500 mg/2 ml for injection in children or adolescents under 16 years have not been established
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.