Klaricid500 mg/vial

Name: Klaricid 500 mg/vial
Brand: Klaricid
Price: 561.36 BDT
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Medicine overview

Indications of Klaricid 500 mg/vial

Klaricid 500 mg/vial is indicated in- Streptococcal pharyngitis Sinusitis Infective exacerbations of chronic bronchitis Community-acquired pneumonia Atypical pneumonia Skin and soft tissue infection Adjunct in the treatment of duodenal ulcers by eradication of H.pylori.

Theropeutic Class

Macrolides

Pharmacology

Klaricid 500 mg/vial acts by inhibiting microsomal protein synthesis in susceptible organisms mainly by binding to the donor site on the 50S sub- unit of the bacterial ribosome and preventing translocation to that site.

Absorption

Klaricid 500 mg/vial is active against most Gram-positive bacteria and Chlamydia, some Gram-negative bacteria and Mycoplasmas. Klaricid 500 mg/vial’s activity is the same as, or greater than, that of erythromycin in vitro against most Gram-positive bacteria.

Distribution

Klaricid 500 mg/vial is more acid stable than erythromycin and therefore, is better tolerated. Klaricid 500 mg/vial has twice the activity of erythromycin against H.

Metabolism

influenzae. Most species of Gram-negative bacteria are resistant to Klaricid 500 mg/vial because of failure to penetrate to the target.

Dosage of Klaricid 500 mg/vial

Adults

Dosage:Pharyngitis / Tonsillitis 250 mg every 12 hours for 10 days

Notes:Acute maxillary sinusitis 500 mg every 12 hours for 14 days. Chronic bronchitis 250-500 mg every 12 hours for 7-14 days. Pneumonia 250 mg every 12 hours for 7-14 days. Uncomplicated skin & skin structure infections 250 mg every 12 hours for 7-14 days. Community-acquired upper and lower respiratory tract infections 250-500 mg every 12 hours for 5-14 days

Children

Dosage:Bodyweight under 8 kg: 7.5 mg/kg twice daily

Bodyweight of 8-11 kg (1-2 years)

Dosage:2.5 ml (Half teaspoonful) twice daily

Bodyweight of 12-19 kg (3-6 years)

Dosage:5 ml (One teaspoonful) twice daily

Bodyweight of 20-29 kg (7-9 years)

Dosage:7.5 ml (One & half teaspoonfuls) twice daily

Bodyweight of 30-40 kg (10-12 years)

Dosage:10 ml (Two teaspoonfuls) twice daily

Condition	Dosage	Notes
Adults	Pharyngitis / Tonsillitis 250 mg every 12 hours for 10 days	Acute maxillary sinusitis 500 mg every 12 hours for 14 days. Chronic bronchitis 250-500 mg every 12 hours for 7-14 days. Pneumonia 250 mg every 12 hours for 7-14 days. Uncomplicated skin & skin structure infections 250 mg every 12 hours for 7-14 days. Community-acquired upper and lower respiratory tract infections 250-500 mg every 12 hours for 5-14 days
Children	Bodyweight under 8 kg: 7.5 mg/kg twice daily
Bodyweight of 8-11 kg (1-2 years)	2.5 ml (Half teaspoonful) twice daily
Bodyweight of 12-19 kg (3-6 years)	5 ml (One teaspoonful) twice daily
Bodyweight of 20-29 kg (7-9 years)	7.5 ml (One & half teaspoonfuls) twice daily
Bodyweight of 30-40 kg (10-12 years)	10 ml (Two teaspoonfuls) twice daily

Administration of Klaricid 500 mg/vial

Klaricid 500 mg/vial may be given with or without meals.

Interaction of Klaricid 500 mg/vial

Theophylline: Concomitant use of Klaricid 500 mg/vial who are receiving Theophylline may be associated with an increase in serum Theophylline concentrations. Terfenadine: Klaricid 500 mg/vial may alter the metabolism of Terfenadine.

Contraindications

Hypersensitivity to Klaricid 500 mg/vial, Erythromycin, or any of the macrolide antibiotics. Patients receiving Terfenadine who have pre-existing cardiac abnormalities or electrolyte disturbances.

Side Effects of Klaricid 500 mg/vial

Klaricid 500 mg/vial is generally well tolerated. Side effects include nausea, vomiting, diarrhoea and abdominal pain. Stomatitis and glossitis have also been reported. Other side effects include headache, allergic reactions ranging from urticaria and mild skin reactions to anaphylaxis. Taste perversion may occur. There have been reports of transient central nervous system side effects including anxiety, dizziness, insomnia and hallucination.

Pregnancy & Lactation

Klaricid 500 mg/vial is not recommended for pregnant women. Breast milk from mothers receiving Klaricid 500 mg/vial should not be given to infants until treatment is completed.

Precautions & Warnings

Klaricid 500 mg/vial is principally excreted by the liver and kidney. Caution should be taken in administering this antibiotic to patients with impaired hepatic and renal function. Prolonged or repeated use of Klaricid 500 mg/vial may result in an overgrowth of non-susceptible bacteria or fungi. If superinfection occurs, Klaricid 500 mg/vial should be discontinued and appropriate therapy should be instituted.

Overdose Effects of Klaricid 500 mg/vial

Reports indicate that the ingestion of large amounts of Klaricid 500 mg/vial can be expected to produce gastro-intestinal symptoms. One patient who had a history of bipolar disorder ingested 8 grams of Klaricid 500 mg/vial and showed altered mental status, paranoid behaviour, hypokalemia and hypoxemia. Adverse reactions accompanying overdosage should be treated by the prompt elimination of unabsorbed drug and supportive measures. As with other macrolides, Klaricid 500 mg/vial serum levels are not expected to be appreciably affected by haemodialysis or peritoneal dialysis.

Storage Conditions

Store in a cool and dry place, protected from light & moisture. The reconstituted suspension must be used within 7 days if kept at room temperature and within 14 days when stored in a refrigerator. Keep out of reach of children.

Use In Special Populations

Klaricid 500 mg/vial may be used in neonates and children in appropriate doses.

Duration Of Treatment

Children older than 12 years and Adult: The usual duration of treatment is 6 to 14 days. Eradication of H. pylori in patients with duodenal ulcers: Adults: The usual duration of treatment is 6 to 14 days.

Reconstitution

45 ml of water is to be added to the granules in the bottle and shaken to yield 70 ml of reconstituted suspension. The concentration of Klaricid 500 mg/vial in the reconstituted suspension is 125 mg per 5 ml.

Drug Classes

Macrolides

Mode Of Action

Klaricid 500 mg/vial acts by inhibiting microsomal protein synthesis in susceptible organisms mainly by binding to the donor site on the 50S subunit of the bacterial ribosome and preventing translocation to that site. Klaricid 500 mg/vial is active against most Gram-positive bacteria and Chlamydia, some Gram-negative bacteria and Mycoplasmas. Klaricid 500 mg/vial's activity is the same as, or greater than, that of Erythromycin in vitro against most Gram-positive bacteria. Klaricid 500 mg/vial is more acid-stable than Erythromycin and therefore, is better tolerated. Klaricid 500 mg/vial has twice the activity of Erythromycin against H. influenzae. Most species of Gram-negative bacteria are resistant to Klaricid 500 mg/vial because of failure to penetrate the target.

Pregnancy

The drug may be used in neonates and children in appropriate doses. Breast milk from mothers receiving Klaricid 500 mg/vial should not be given to infants until treatment is completed. There is as yet little experience in the treatment of pregnant patients and Klaricid 500 mg/vial is not recommended.

Frequently Asked Questions

What is Klaricid 500 mg/vial used for?

Clarithromycin is indicated in- Streptococcal pharyngitis Sinusitis Infective exacerbations of chronic bronchitis Community-acquired pneumonia Atypical pneumonia Skin and soft tissue infection Adjunct in the treatment of duodenal ulcers by eradication of H.pylori.

What is the dosage of Klaricid 500 mg/vial?

Adults: Pharyngitis / Tonsillitis 250 mg every 12 hours for 10 days. Acute maxillary sinusitis 500 mg every 12 hours for 14 days. Chronic bronchitis 250-500 mg every 12 hours for 7-14 days. Pneumonia 250 mg every 12 hours for 7-14 days. Uncomplicated skin & skin structure infections 250 mg every 12 hours for 7-14 days. Community-acquired upper and lower respiratory tract infections 250-500 mg ever…

What are the side effects of Klaricid 500 mg/vial?

Clarithromycin is generally well tolerated. Side effects include nausea, vomiting, diarrhoea and abdominal pain. Stomatitis and glossitis have also been reported. Other side effects include headache, allergic reactions ranging from urticaria and mild skin reactions to anaphylaxis. Taste perversion may occur. There have been reports of transient central nervous system side effects including anxiety…

Who should not take Klaricid 500 mg/vial?

Hypersensitivity to Clarithromycin, Erythromycin, or any of the macrolide antibiotics. Patients receiving Terfenadine who have pre-existing cardiac abnormalities or electrolyte disturbances.

What precautions should be taken with Klaricid 500 mg/vial?

Clarithromycin is principally excreted by the liver and kidney. Caution should be taken in administering this antibiotic to patients with impaired hepatic and renal function. Prolonged or repeated use of Clarithromycin may result in an overgrowth of non-susceptible bacteria or fungi. If superinfection occurs, Clarithromycin should be discontinued and appropriate therapy should be instituted.

Is Klaricid 500 mg/vial safe during pregnancy and breastfeeding?

Clarithromycin is not recommended for pregnant women. Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.