Lanso D

Lanso D30 mg

Capsule

Dexlansoprazole

Square Pharmaceuticals PLC.

Product Code : 9256
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Medicine overview

Indications of Lanso D 30 mg

Healing of Erosive Esophagitis: Lanso D 30 mg is indicated for the healing of all grades of erosive esophagitis (EE) for up to 8 weeks.Maintenance of Healed Erosive Esophagitis: Lanso D 30 mg is indicated to maintain healing of EE and relief of heartburn ... Read moreHealing of Erosive Esophagitis: Lanso D 30 mg is indicated for the healing of all grades of erosive esophagitis (EE) for up to 8 weeks.Maintenance of Healed Erosive Esophagitis: Lanso D 30 mg is indicated to maintain healing of EE and relief of heartburn for up to 6 months.Symptomatic Non-Erosive Gastroesophageal Reflux Disease: Lanso D 30 mg is indicated for the treatment of heartburn associated with symptomatic non-erosive Gastroesophageal Reflux Disease (GERD) for 4 weeks.

Theropeutic Class

Proton Pump Inhibitor

Pharmacology

Lanso D 30 mg delayed-release capsule is a Proton Pump Inhibitor (PPI), that inhibits gastric acid secretion. It is the R-enantiomer of lansoprazole (A racemic mixture of the R- and S-enantiomers). This is supplied as a Dual Delayed Release (DDR) formulation in a capsule for oral administration. Lanso D 30 mg capsule contains a mixture of two types of enteric coated granules with different pH-dependent dissolution profiles.Lanso D 30 mg is a PPI that suppresses gastric acid secretion by specific inhibition of the (H+/K+)-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Lanso D 30 mg blocks the final step of acid production.

Dosage of Lanso D 30 mg

Lanso D 30 mg dosing recommendations- Maintenance of Healed erosive esophagitis and relief of heartburn: 30 mg Once daily Symptomatic Non-Erosive GERD: 30 mg Once daily for 4 weeks Healing of erosive esophagitis: 60 mg Once daily for up to 8 weeks

Administration of Lanso D 30 mg

Lanso D 30 mg can be taken without regard to food. It should be swallowed whole. Alternatively, Lanso D 30 mg capsules can be administered as follows: Open capsule Sprinkle intact granules on one tablespoon Swallow immediately. Granules should not be chewed.If a capsule is missed at its usual time, it should be taken as soon as possible. But if it is too close to the time of the next dose, only the prescribed dose should be taken at the appointed time. A double dose should not be taken.

Interaction of Lanso D 30 mg

With medicine: Atazanavir, Warfarin, Tacrolimus, Clopidogrel & Methotrexate. With food & others: No data available.

Contraindications

Lanso D 30 mg is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects of Lanso D 30 mg

Common side effects: Diarrhea, abdominal pain, nausea, vomiting & flatulence.

Pregnancy & Lactation

There are no adequate or well-controlled studies in pregnant women with Lanso D 30 mg. Exposure in clinical trials was very limited. Lanso D 30 mg should not be administered to pregnant women unless the expected benefits outweigh the potential risks. It is not known whether Lanso D 30 mg is excreted in human milk. However, Lanso D 30 mg and its metabolites are excreted in the milk of rats. As many drugs are excreted in human milk, Lanso D 30 mg should not be given to nursing mothers unless its use is considered

Precautions & Warnings

Gastric Malignancy, Clostridium difficile Associated Diarrhea, Bone fracture, Hypomagnesemia, and concomitant use of Lanso D 30 mg with Methotrexate.

Overdose Effects of Lanso D 30 mg

There have been no reports of a significant overdose of Lanso D 30 mg. Multiple doses of Lanso D 30 mg 120 mg and a single dose of Lanso D 30 mg 300 mg did not result in death or other severe adverse events.

Storage Conditions

Store below 30°C temperature & in a dry place, protected from light. Keep all medicines out of reach of children.

Use In Special Populations

Geriatrics: No dosage adjustment is necessary for elderly patients.Pediatrics: Safety and effectiveness of Lanso D 30 mg in patients below 12 years age have not been established yet.Renal Impairment: No dosage adjustment is necessary for patients with renal impairment.Hepatic Impairment: No adjustment of Lanso D 30 mg is necessary for patients with mild hepatic impairment. A maximum daily dose of 30 mg for patients with moderate hepatic impairment may be considered.

Drug Classes

Proton Pump Inhibitor

Mode Of Action

Lanso D 30 mg delayed-release capsule is a Proton Pump Inhibitor (PPI) which suppresses gastric acid secretion by specific inhibition of the (H+/K+)-ATPase in the gastric parietal cell. By acting specifically on the proton pump, Lanso D 30 mg blocks the final step of acid production. It is the R-enantiomer of lansoprazole (A racemic mixture of the R- and S-enantiomers). Lanso D 30 mg is supplied as a Dual Delayed Release (DDR) formulation in a capsule for oral administration. This capsule contains a mixture of two types of enteric coated granules with different pH-dependent dissolution profiles. The dual delayed release formulation in Lanso D 30 mg, plasma concentration-time profile with two distinct peaks; the first peak occurs 1 to 2 hours after administration, followed by a second peak within 4 to 5 hours. After oral administration, mean Cmax and AUC value of Lanso D 30 mg increased approximately dose proportionally. Lanso D 30 mg is extensively metabolized in the liver and excreated by urine.

Pregnancy

Pregnancy Category B. There is no adequate and well-controlled studies with Lanso D 30 mg in pregnant women. There is no adequate and well-controlled studies with Lanso D 30 mg in Lactating mother.

Pediatric Uses

Use in children & adolescents: Safety and effectiveness of Lanso D 30 mg in patients below 12 years age have not been established.Geriatric use: No dose adjustment is necessary for elderly patients.Renal impairment: No dose adjustment of Lanso D 30 mg is necessary for patients with renalimpairment.Hepatic impairment: No dose adjustment for Lanso D 30 mg is necessary for patients with mild hepatic impairment. A maximum daily dose of Lanso D 30 mg 30 mg should be considered for patients with moderate hepatic impairment.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.