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Leukin50 mg
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Medicine overview
Indications of Leukin 50 mg
Leukin 50 mg is indicated for maintenance therapy of acute lymphatic (lymphocyticchronic lymphatic leukemiathe lymphomas (including Hodgkins Disease)or solid tumors.
Theropeutic Class
Cytotoxic Chemotherapy
Pharmacology
Leukin 50 mg is a purine antagonist which is converted intracellularly into its active nucleotides, including thioinosinic acid.
Absorption
The nucleotides inhibit several reactions which ultimately interferes with nucleic acid synthesis and prevents the formation of RNA and DNA.
Dosage of Leukin 50 mg
Crohn's disease
Dosage:Adult: Initially 1-1.5 mg/kg daily, may increase to 125 mg daily
Child
Dosage:Initially 1-1.5 mg/kg daily increased to a max of 75 mg daily Acute lymphocytic leukemia: Adult: Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate
Notes:Dose may vary individually based on response and tolerance. Monitor blood counts at least once wkly. Withdraw treatment immedietely if there is a sharp drop in the white cell count or severe bone-marrow depression. May resume treatment slowly and carefully if white cell count remains constant for 2-3 days or rises. Reduce dose when used with allopurinol
Child
Dosage:Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate
Notes:Dose may vary individually based on response and tolerance. Monitor blood counts at least once wkly. Withdraw treatment immedietely if there is a sharp drop in the white cell count or severe bone-marrow depression. May resume treatment slowly and carefully if white cell count remains constant for 2-3 days or rises. Reduce dose when used with allopurinol
| Condition | Dosage | Notes |
|---|---|---|
| Crohn's disease | Adult: Initially 1-1.5 mg/kg daily, may increase to 125 mg daily | |
| Child | Initially 1-1.5 mg/kg daily increased to a max of 75 mg daily Acute lymphocytic leukemia: Adult: Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate | Dose may vary individually based on response and tolerance. Monitor blood counts at least once wkly. Withdraw treatment immedietely if there is a sharp drop in the white cell count or severe bone-marrow depression. May resume treatment slowly and carefully if white cell count remains constant for 2-3 days or rises. Reduce dose when used with allopurinol |
| Child | Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate | Dose may vary individually based on response and tolerance. Monitor blood counts at least once wkly. Withdraw treatment immedietely if there is a sharp drop in the white cell count or severe bone-marrow depression. May resume treatment slowly and carefully if white cell count remains constant for 2-3 days or rises. Reduce dose when used with allopurinol |
Administration of Leukin 50 mg
Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. Ensure adequate fluid intake.
Interaction of Leukin 50 mg
Anticoagulant action of warfarin may be inhibited by Leukin 50 mg. Enhanced toxicity with myelosuppressive drugs.
Contraindications
Pregnancy and lactation. Prior resistance to Leukin 50 mg or thioguanine; severe liver disease; severe bone marrow suppression.
Side Effects of Leukin 50 mg
Hyperuricaemia, bone marrow toxicity, hypoplasia, anorexia, diarrhoea, leukopenia, thrombocytopenia, intestinal ulceration, crystalluria with haematuria, immunosuppression, interstitial pneumonitis. Cutaneous hyperpigmentation, alopecia.
Pregnancy & Lactation
Pregnancy category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Precautions & Warnings
Hepatic or renal dysfunction; monitor hepatic function periodically. Leukin 50 mg is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) deficiency; porphyria.
Storage Conditions
Store at 20-25° C
Use In Special Populations
Renal Impairment: Dosage may need to be reduced.Hepatic Impairment:
Crohn's disease: Dosage may need to be reduced.
Acute lymphocytic leukemia: Dosage may need to be reduced
Dosage adjustment in patients with thiopurine-S-methyl transferase (TPMT) deficiency to prevent life-threatening myelotoxicity. For patients with homozygous TPMT deficiency: Substantial reduction is required. For patients with heterozygous TPMT deficiency: Some may require reduction but most will tolerate the usual dosages.
Drug Classes
Cytotoxic Chemotherapy
Mode Of Action
Leukin 50 mg is a purine antagonist which is converted intracellularly into its active nucleotides, including thioinosinic acid. The nucleotides inhibit several reactions which ultimately interferes with nucleic acid synthesis and prevents the formation of RNA and DNA.
Pregnancy
Pregnancy category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Pediatric Uses
Renal Impairment: Dosage may need to be reduced.Hepatic Impairment:
Crohn's disease: Dosage may need to be reduced.
Acute lymphocytic leukemia: Dosage may need to be reduced
Dosage adjustment in patients with thiopurine-S-methyl transferase (TPMT) deficiency to prevent life-threatening myelotoxicity. For patients with homozygous TPMT deficiency: Substantial reduction is required. For patients with heterozygous TPMT deficiency: Some may require reduction but most will tolerate the usual dosages.
Frequently Asked Questions
What is Leukin 50 mg used for?
Mercaptopurine is indicated for maintenance therapy of acute lymphatic (lymphocytic, lymphoblastic) leukemiaas part of a combination regimen. The response to this agent depends upon the particular subclassification of acute lymphatic leukemia and the age of the patient (pediatric ... Read moreMercaptopurine is indicated for maintenance therapy of acute lymphatic (lymphocytic, lymphoblastic) leukem…
What is the dosage of Leukin 50 mg?
Crohn's disease: Adult: Initially 1-1.5 mg/kg daily, may increase to 125 mg daily. Child: Initially 1-1.5 mg/kg daily increased to a max of 75 mg daily Acute lymphocytic leukemia: Adult: Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate. Dose may vary individually based on response and tolerance. Monitor blood counts at least onc…
What are the side effects of Leukin 50 mg?
Hyperuricaemia, bone marrow toxicity, hypoplasia, anorexia, diarrhoea, leukopenia, thrombocytopenia, intestinal ulceration, crystalluria with haematuria, immunosuppression, interstitial pneumonitis. Cutaneous hyperpigmentation, alopecia.
Who should not take Leukin 50 mg?
Pregnancy and lactation. Prior resistance to mercaptopurine or thioguanine; severe liver disease; severe bone marrow suppression.
What precautions should be taken with Leukin 50 mg?
Hepatic or renal dysfunction; monitor hepatic function periodically. Mercaptopurine is potentially carcinogenic. Thiopurine S-methyl transferase (TPMT) deficiency; porphyria.
Is Leukin 50 mg safe during pregnancy and breastfeeding?
Pregnancy category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.