Liconor250 mg/5 ml

Liconor 250 mg/5 ml is indicated for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH).

Anti-gallstones drugs: Bile Acids

Liconor 250 mg/5 ml is a naturally occurring bile acid used to treat different hepatobilliary disorders. The activity of Liconor 250 mg/5 ml is achieved through a decrease in secretion of cholesterol in bile. Liconor 250 mg/5 ml achieves this through a few mechanisms: it reduces cholesterol absorption, suppresses liver cholesterol synthesis and it does not inhibit bile acid synthesis.Therefore, alters bile composition from supersaturated to unsaturated. Liconor 250 mg/5 ml also promotes the formation of liquid cholesterol crystal complexes which enhance removal of the cholesterol from the gallbladder into the intestine to be expelled. Liconor 250 mg/5 ml improves cholestatic liver diseases by- Protecting cholangiocytes against cytotoxicity of hydrophobic bile acids Stimulating hepatobilliary secretion Protecting hepatocytes against bile acid-induced apoptosis Liconor 250 mg/5 ml is completely absorbed in the upper intestine. Time to peak serum concentration varies from 30 to 150 minutes. The rate of absorption ranges from 60-80%. After absorption Liconor 250 mg/5 ml enters the portal vein and undergoes extraction from portal blood by liver where it is conjugated with amino acid & that may be either glycine or taurine and then secreted into the hepatic bile ducts. Small quantities of Liconor 250 mg/5 ml appear in the circulation and very small amounts are excreted into urine. The biologic half life of Liconor 250 mg/5 ml ranges from 3.5-5.8 days.

Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided dosesPBC: 10-15 mg/kg/day in 2-4 divided dosesAcute Viral Hepatitis: 600 mg/dayAlcoholic Fatty Liver: 300 mg/dayPSC: 25-30 mg/kg/dayNASH: 13-15 mg/kg/day

Liconor 250 mg/5 ml should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided, since this may reduce the effectiveness of therapy with Ursodeoxycholic acid.

Non-functioning gall-bladder calcified and pigmented gallstones, inflammatory bowel disease.

Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone opacilication, pruritus.

Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breast feeding.

It should be used cautiously in those with liver disease.

Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.