Hypertension: It is recommended to use LK 25 mg to treat hypertension. It could be used with other antihypertensive medications or taken alone (eg. thiazide diuretics). Renal Protection in Type-2 Diabetic Patients with Proteinuria: In hypertensive type-2 diabetics with proteinuria, which is defined as urine albumin to creatinine ratio >300 mg/g, LK 25 mg is advised to postpone the advancement of renal disease.

Theropeutic Class

Angiotensin-ll receptor blocker

Pharmacology

The first angiotensin II receptor blocker that is orally active without a peptide is LK 25 mg. It binds to the AT1 receptor, which is present in numerous tissues (such as the heart, kidneys, adrenal glands, and vascular smooth muscle), and inhibits several critical biological processes, such as vasoconstriction and the production of the hormone aldosterone that causes hypertension.

Dosage & Administration of LK 25 mg

For the majority of patients, the beginning and maintenance dose is 50 mg once daily. Prior to raising the dose, 25 mg twice daily is advised if the antihypertensive impact of 50 mg once daily is insufficient. A starting dose of 25 mg once daily should be taken into consideration for individuals with intravascular volume depletion (such as those on high-dose diuretics). One or two doses of LK 25 mg can be given each day. From 25 mg to 100 mg is the range for the total daily dose.

Dosage of LK 25 mg

Interaction of LK 25 mg

Levels of the LK 25 mg active metabolite are decreased by rifampicin and fluconazole. The antihypertensive effects of hydrochlorothiazide and LK 25 mg used together may be potentiated. Increases in serum potassium may result from the concurrent use of potassium-sparing diuretics (such as spironolactone, triamterene, and amiloride), potassium supplements, or salt substitutes containing potassium. The non-steroidal anti-inflammatory medicine indomethacin may lessen the antihypertensive effects of losartan. The risk of renal impairment is increased by the concurrent use of an ACE inhibitor, an angiotensin receptor antagonist, an anti-inflammatory medication, and a thiazide diuretic.

Contraindications

Pregnant women and individuals who are hypersensitive to any ingredient in this medication should not use LK 25 mg. Those with diabetes shouldn't take Aliskiren and LK 25 mg together.

Side Effects of LK 25 mg

LK 25 mg side effects are minor and short-lived in nature. Dizziness, diarrhea, nasal congestion, coughing, and upper respiratory infections are the most frequent adverse effects. Fatigue, oedema, chest pain, nausea, headaches, and pharyngitis are other adverse effects.

Pregnancy & Lactation

Category D for pregnancies. If LK 25 mg is given during the second or third trimester of pregnancy, the risk to the fetus increases. Given that numerous medicines are excreted in human milk and that it is unknown whether LK 25 mg is one of them, a choice should be taken regarding whether to stop breastfeeding or stop taking the medication, taking into account the significance of the medication to the mother.

Precautions & Warnings

In addition to increasing fetal and neonatal morbidity and mortality, the use of LK 25 mg throughout the second and third trimesters of pregnancy decreases fetal renal function. Symptomatic hypotension may happen in people who are intravascularly volume-depleted (such as those taking high-dose diuretics). Patients with cirrhosis have a considerably higher plasma concentration of LK 25 mg. Patients with renal impairment have experienced changes in renal function, including renal failure.

Storage Conditions

Keep dry and away from heat and light. Keep out of children's reach.

Drug Classes

Angiotensin-ll receptor blocker

Mode Of Action

Pregnancy

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.