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Lomir

Lomir2.5 mg

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Medicine overview

Indications of Lomir 2.5 mg

Lomir 2.5 mg is indicated in the management of hypertension. It may be used alone or concurrently with thiazide-type diuretics.

Theropeutic Class

Calcium-channel blockers

Pharmacology

Lomir 2.5 mg is a dihydropyridine Calcium channel blocker.

Excretion

It prevents Ca++ ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.

Dosage & Administration of Lomir 2.5 mg

Adult
Dosage:Initially, 2.5 mg bid, increase if necessary after 3-4 wk to 5 mg bid, or 10 mg bid as required
Elderly
Dosage:Initially, 1.25 mg bid
Maintenance
Dosage:2.5 or 5 mg once daily
Hepatic Impairment
Dosage:Initially 1.25 mg bid
Maintenance
Dosage:2.5 or 5 mg once daily
Notes:May be taken with or without food

Dosage of Lomir 2.5 mg

Adult
Dosage:Initially, 2.5 mg bid, increase if necessary after 3-4 wk to 5 mg bid, or 10 mg bid as required
Elderly
Dosage:Initially, 1.25 mg bid
Maintenance
Dosage:2.5 or 5 mg once daily
Hepatic Impairment
Dosage:Initially 1.25 mg bid
Maintenance
Dosage:2.5 or 5 mg once daily
Notes:May be taken with or without food

Interaction of Lomir 2.5 mg

Concurrent admin with enzyme-inducing drugs (e.g. rifampicin, phenobarbital, carbamazepine) reduced plasma concentrations of Lomir 2.5 mg. Increased bioavailability with cimetidine. May increase serum levels with CYP3A4 inhibitors (e.g. macrolides, HIV protease inhibitors, azole antifungals, delavirdine).

Contraindications

Cardiogenic shock, within 1 mth of MI, unstable angina, treatment of hypertensive crisis.

Side Effects of Lomir 2.5 mg

Headache, dizziness, palpitations, tachycardia, peripheral oedema, flushing, dyspnoea, abdominal discomfort, rash, pruritus, polyuria, fatigue, malaise.

Pregnancy & Lactation

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus

Precautions & Warnings

Patients with CHF, severe aortic stenosis, hypertrophic cardiomyopathy with outflow tract obstruction. Hepatic impairment. Pregnancy and lactation.

Overdose Effects of Lomir 2.5 mg

Symptoms: Excessive peripheral vasodilation with subsequent marked and prolonged systemic hypotension and tachycardia. Management: Symptomatic and supportive treatment. Emesis, gastric lavage, admin of activated charcoal followed in 30 min by a saline cathartic. A vasoconstrictor (e.g. epinephrine) may be useful in restoring normotensive state. Refractory hypotension or AV conduction disturbances may be treated with IV Ca salts or glucagon.

Storage Conditions

Store below 30° C.

Drug Classes

Calcium-channel blockers

Mode Of Action

Lomir 2.5 mg is a dihydropyridine Calcium channel blocker. It prevents Ca++ ions from entering the slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarisation, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation.

Pregnancy

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus

Frequently Asked Questions

What is Lomir 2.5 mg used for?

Isradipine is indicated in the management of hypertension. It may be used alone or concurrently with thiazide-type diuretics.

What is the dosage of Lomir 2.5 mg?

Adult: Initially, 2.5 mg bid, increase if necessary after 3-4 wk to 5 mg bid, or 10 mg bid as required.Elderly: Initially, 1.25 mg bid. Maintenance: 2.5 or 5 mg once daily.Hepatic Impairment: Initially 1.25 mg bid. Maintenance: 2.5 or 5 mg once daily.May be taken with or without food.

What are the side effects of Lomir 2.5 mg?

Headache, dizziness, palpitations, tachycardia, peripheral oedema, flushing, dyspnoea, abdominal discomfort, rash, pruritus, polyuria, fatigue, malaise.

Who should not take Lomir 2.5 mg?

Cardiogenic shock, within 1 mth of MI, unstable angina, treatment of hypertensive crisis.

What precautions should be taken with Lomir 2.5 mg?

Patients with CHF, severe aortic stenosis, hypertrophic cardiomyopathy with outflow tract obstruction. Hepatic impairment. Pregnancy and lactation.

Is Lomir 2.5 mg safe during pregnancy and breastfeeding?

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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