Melphin50 mg/ml

This medication is used to treat intestinal worm infections such as pinworm, roundworm, and hookworm. Pyrantel belongs to a class of drugs known as anthelmintics. It works by making the worms unable to move (paralyzed) so that the body can remove them naturally in the stool.... Read more

Anthelmintic

Pyrantel pamoate acts as a depolarizing neuromuscular blocking agent, thereby causing sudden contraction, followed by paralysis, of the helminths. This has the result of causing the worm to "lose its grip" on the intestinal wall and be passed out of the system by natural process. Since Pyrantel is poorly absorbed by the host's intestine, the host is unaffected by the small dosage of medication used. Spastic (tetanic) paralyzing agents, in particular Melphin 50 mg/ml, may induce complete intestinal obstruction in a heavy worm load. This obstruction is usually in the form of a worm impaction and happens when a very small, but heavily parasitized animal is treated and tries to pass a large number of dislodged worms at once. Worms usually pass in normal stool or with diarrhea, straining, and occasional vomiting.

Melphin 50 mg/ml is given orally at anytime without regard to ingestion of food or beverages. A single dose of 11 mg/kg body weight, to a maximum of 1 gm, should be given to treat infestations caused by the parasites mentioned above. In the case of Pinworm, it is often wise to repeat the dose after an interval of 2 weeks.

Known hypersensitivity to pyrantel or any ingredient in the formulation.

Melphin 50 mg/ml is well tolerated in recommended dosage. When given in large dosage, Melphin 50 mg/ml may cause gastrointestinal upset such as anorexia, nausea, vomiting and diarrhoea. Other side effects that may occur in rare occasions are headache, dizziness and rash.

Pregnancy: Since Melphin 50 mg/ml has not been studied in pregnant women, use of Melphin 50 mg/ml in such patients is normally contraindicated. Melphin 50 mg/ml is not recommended for children below 1 year of age.

Since Melphin 50 mg/ml and Piperazine appear to be mutually antagonistic, Melphin 50 mg/ml should not be given together with Piperazine. Melphin 50 mg/ml should be kept out of the reach of children.

Pediatric Use: Safety and efficacy not established in children <2 years of age;a use in this age group only when potential benefits justify possible risks.Hepatic Impairment: Use with caution in patients with preexisting liver dysfunction.