Nalbutin10 mg/ml
IM/IV Injection
Medicine overview
Indications of Nalbutin 10 mg/ml
Theropeutic Class
Pharmacology
Nalbutin 10 mg/ml Hydrochloride is a synthetic potent analgesic.
Its analgesic potency is essentially equivalent to that of morphine on a milligram basis.
Receptor studies show that Nalbutin 10 mg/ml binds to mu, kappa, and delta receptors, but not to sigma receptors.
Nalbutin 10 mg/ml is primarily a kappa agonist/partial mu antagonist analgesic.
Dosage & Administration of Nalbutin 10 mg/ml
| Condition | Dosage | Notes |
|---|---|---|
| The usual recommended adult dose is 10 mg for a 70 kg individual, administered subcutaneously, intramuscularly or intravenously; this dose may be repeated every 3 to 6 hours as necessary. Dosage should be adjusted according to the severity of the pain, physical status of the patient, and other medications which the patient may bereceiving | ||
| Moderate to severe pain | by intravenous or intramuscular injection 10-20 mg for 70 kg patient, adjusted as required; child up to 0.3 mg/kg repeated once or twice as necessary | |
| Preoperative anesthesia | by intravenous or intramuscular injection 0.1-0.2 mg/kg | |
| Obstetrical analgesia during labor & delivery | by intravenous injection 0.3-1 mg/kg over 10-15 minutes with maintenance doses of 0.25-0.5 mg/kg in single intravenous administration as required | |
| Intraoperative analgesia | by intravenous injection 0.25-0.5 mg/kg at 30 minutes intervals | |
| Myocardial infarction | By slow intravenous injection 10-20 mg, repeated after 30 minutes if necessary | Larger dose is required when used as supplement of anesthesia than that required for analgesia |
| Children from 18 months to 15 years old | usually 0.2 mg/ kg body-weight, given preferably by intravenous or intramuscular injection | Maintenance doses may be given at intervals of 4 to 6 hours or the dose must be determined by the physician |
Dosage of Nalbutin 10 mg/ml
| Condition | Dosage | Notes |
|---|---|---|
| The usual recommended adult dose is 10 mg for a 70 kg individual, administered subcutaneously, intramuscularly or intravenously; this dose may be repeated every 3 to 6 hours as necessary. Dosage should be adjusted according to the severity of the pain, physical status of the patient, and other medications which the patient may bereceiving | ||
| Moderate to severe pain | by intravenous or intramuscular injection 10-20 mg for 70 kg patient, adjusted as required; child up to 0.3 mg/kg repeated once or twice as necessary | |
| Preoperative anesthesia | by intravenous or intramuscular injection 0.1-0.2 mg/kg | |
| Obstetrical analgesia during labor & delivery | by intravenous injection 0.3-1 mg/kg over 10-15 minutes with maintenance doses of 0.25-0.5 mg/kg in single intravenous administration as required | |
| Intraoperative analgesia | by intravenous injection 0.25-0.5 mg/kg at 30 minutes intervals | |
| Myocardial infarction | By slow intravenous injection 10-20 mg, repeated after 30 minutes if necessary | Larger dose is required when used as supplement of anesthesia than that required for analgesia |
| Children from 18 months to 15 years old | usually 0.2 mg/ kg body-weight, given preferably by intravenous or intramuscular injection | Maintenance doses may be given at intervals of 4 to 6 hours or the dose must be determined by the physician |
Interaction of Nalbutin 10 mg/ml
Contraindications
Side Effects of Nalbutin 10 mg/ml
Pregnancy & Lactation
Precautions & Warnings
Overdose Effects of Nalbutin 10 mg/ml
Storage Conditions
Drug Classes
Mode Of Action
Pregnancy
Frequently Asked Questions
What is Nalbutin 10 mg/ml used for?
Nalbuphine Hydrochloride is indicated for the relief of moderate to severe pain. It is used for relief of moderate to severe pain associated with myocardial infarction (MI). Nalbuphine Hydrochloride can also be used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.
What is the dosage of Nalbutin 10 mg/ml?
The usual recommended adult dose is 10 mg for a 70 kg individual, administered subcutaneously, intramuscularly or intravenously; this dose may be repeated every 3 to 6 hours as necessary. Dosage should be adjusted according to the severity of the pain, physical status of the patient, and other medications which the patient may bereceiving.Moderate to severe pain: by intravenous or intramuscular in…
What are the side effects of Nalbutin 10 mg/ml?
Generally Nalbuphine is well tolerated. However few side-effects like sedation, sweating, nausea, vomiting, dizziness, vertigo, dry mouth, headache, respiratory depression, dyspnea and asthma may be seen.
Who should not take Nalbutin 10 mg/ml?
Known hypersensitivity to Nalbuphine Hydrochloride.
What precautions should be taken with Nalbutin 10 mg/ml?
Caution should be taken in the following conditions: impaired respiration, impaired renal or hepatic function, billiary tract surgery, myocardial infarction and hypotension.
Is Nalbutin 10 mg/ml safe during pregnancy and breastfeeding?
Pregnancy category B. The placental transfer of Nalbuphine is high and rapid. There are no well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Limited data suggest that Nalbuphine is excreted in maternal milk but only in a small amount (less than 1% of the administered dose) and with a clinically insignificant effect. Caution should be exerc…
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