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Natagen5%
General Pharmaceuticals Ltd.
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Natoph5%
Ophthalmic Suspension
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Medicine overview
Indications of Natoph 5%
Natoph 5% sterile ophthalmic suspension is indicated for the treatment of fungal blepharitisconjunctivitis and keratitis caused by susceptible organisms including Fusarium solani.
Theropeutic Class
Ophthalmic antibacterial drugs
Pharmacology
Natoph 5% is a tetraene polyene antibiotic derived from Streptomyces natalensis.
Absorption
Natoph 5% probably exerts its antifungal effects by binding to sterols in the fungal cell membrane to produce a change in membrane permeability that allows loss of essential cellular constituents.
Distribution
It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium.
Metabolism
Although the activity against fungi is dose-related, Natoph 5% is predominantly fungicidal.
Excretion
Topical administration appears to produce effective concentration of Natoph 5% within the corneal stroma but not in intraocular fluid.
Dosage & Administration of Natoph 5%
For fungal keratitis
Dosage:The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval
Notes:The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated
For fungal blepharitis & conjunctivitis
Dosage:Less frequent initial dosage, 1 drop 4-6 times daily may be sufficient
| Condition | Dosage | Notes |
|---|---|---|
| For fungal keratitis | The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval | The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated |
| For fungal blepharitis & conjunctivitis | Less frequent initial dosage, 1 drop 4-6 times daily may be sufficient |
Dosage of Natoph 5%
For fungal keratitis
Dosage:The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval
Notes:The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated
For fungal blepharitis & conjunctivitis
Dosage:Less frequent initial dosage, 1 drop 4-6 times daily may be sufficient
| Condition | Dosage | Notes |
|---|---|---|
| For fungal keratitis | The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval | The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated |
| For fungal blepharitis & conjunctivitis | Less frequent initial dosage, 1 drop 4-6 times daily may be sufficient |
Interaction of Natoph 5%
May increase spread of fungal eye infection when used with topical corticosteroid.
Contraindications
Natoph 5% ophthalmic suspension is contraindicated in individuals with a history of hypersensitivity to any of its component.
Side Effects of Natoph 5%
Eye irritation, eye discomfort, eye edema, conjunctival chemosis and hyperemia has been reported.
Pregnancy & Lactation
Pregnancy Category C. Natoph 5% sterile ophthalmic suspension should be given to a pregnant woman only if clearly needed.Lactation: It is not known whether this drug is excreted in human milk. Caution should be exercised when Natoph 5% is administered to a nursing mother.
Precautions & Warnings
For topical eye use only. Failure of improvement of keratitis following 7-10 days of administration of the drug suggests that the infection may be caused by a microorganism not susceptible to Natoph 5%.
Storage Conditions
Store in a cool and dry place. Protect from light. Do not freeze. Do not use for longer than one month after first opening of the bottle.
Use In Special Populations
Pediatric: Safety and effectiveness in paediatric patients have not been established.
Drug Classes
Ophthalmic antibacterial drugs
Mode Of Action
Natoph 5% is a tetraene polyene antibiotic derived from Streptomyces natalensis. Natoph 5% probably exerts its antifungal effects by binding to sterols in the fungal cell membrane to produce a change in membrane permeability that allows loss of essential cellular constituents. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, Natoph 5% is predominantly fungicidal. Topical administration appears to produce effective concentration of Natoph 5% within the corneal stroma but not in intraocular fluid.
Pregnancy
Pregnancy Category C. Natoph 5% sterile ophthalmic suspension should be given to a pregnant woman only if clearly needed.Lactation: It is not known whether this drug is excreted in human milk. Caution should be exercised when Natoph 5% is administered to a nursing mother.
Pediatric Uses
Pediatric: Safety and effectiveness in paediatric patients have not been established.
Frequently Asked Questions
What is Natoph 5% used for?
Natamycin sterile ophthalmic suspension is indicated for the treatment of fungal blepharitis, conjunctivitis and keratitis caused by susceptible organisms including Fusarium solani.
What is the dosage of Natoph 5%?
For fungal keratitis: The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval. The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage graduall…
What are the side effects of Natoph 5%?
Eye irritation, eye discomfort, eye edema, conjunctival chemosis and hyperemia has been reported.
Who should not take Natoph 5%?
Natamycin ophthalmic suspension is contraindicated in individuals with a history of hypersensitivity to any of its component.
What precautions should be taken with Natoph 5%?
For topical eye use only. Failure of improvement of keratitis following 7-10 days of administration of the drug suggests that the infection may be caused by a microorganism not susceptible to natamycin.
Is Natoph 5% safe during pregnancy and breastfeeding?
Pregnancy Category C. Natamycin sterile ophthalmic suspension should be given to a pregnant woman only if clearly needed.Lactation: It is not known whether this drug is excreted in human milk. Caution should be exercised when Natamycin is administered to a nursing mother.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.