Naproxen is indicated for the relief of sign and symptoms of rheumatoid arthritisosteoarthritisankylosing spondylitisjuvenile arthritistendonitisbursitis & acute gout. It is also indicated for the management of primary dysmenorrhea & pain.

Theropeutic Class

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Pharmacology

Naproxen is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic & antipyretic properties.

Absorption

It is rapidly absorbed from the gastrointestinal tract and achieves 95% bioavailability.

Dosage & Administration of Nipoxen SR 500 mg

Notes:Naproxen Tablet- Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis: The usual dose is 500-1000 mg daily in two divided doses after meals. Management of pain, primary dysmenorrhea, acute tendonitis & bursitis: Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg

Acute gout

Dosage:Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided

Naproxen Suspension- For Juvenile rheumatoid arthritis

Dosage:The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hours intervals

Notes:Therapy in children under 2 years of age is not recommended. Naproxen Gel- Is to be applied 2-6 times a day as required and is not recommended for use in children

Condition	Dosage	Notes
		Naproxen Tablet- Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis: The usual dose is 500-1000 mg daily in two divided doses after meals. Management of pain, primary dysmenorrhea, acute tendonitis & bursitis: Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg
Acute gout	Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided
Naproxen Suspension- For Juvenile rheumatoid arthritis	The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hours intervals	Therapy in children under 2 years of age is not recommended. Naproxen Gel- Is to be applied 2-6 times a day as required and is not recommended for use in children

Dosage of Nipoxen SR 500 mg

Acute gout

Dosage:Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided

Naproxen Suspension- For Juvenile rheumatoid arthritis

Dosage:The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hours intervals

Notes:Therapy in children under 2 years of age is not recommended. Naproxen Gel- Is to be applied 2-6 times a day as required and is not recommended for use in children

Condition	Dosage	Notes
		Naproxen Tablet- Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis: The usual dose is 500-1000 mg daily in two divided doses after meals. Management of pain, primary dysmenorrhea, acute tendonitis & bursitis: Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total daily dose should not exceed 1000 mg
Acute gout	Recommended starting dose is 750 mg followed by 250 mg every 8 hours until the attack has subsided
Naproxen Suspension- For Juvenile rheumatoid arthritis	The usual dose for children over 2 years is 10 mg/kg/day given as two divided doses at 12-hours intervals	Therapy in children under 2 years of age is not recommended. Naproxen Gel- Is to be applied 2-6 times a day as required and is not recommended for use in children

Interaction of Nipoxen SR 500 mg

ACE inhibitors: diminish the antihypertensive effect of ACE inhibitors.Antacids & Sucralfate: delay the absorption of Naproxen. Aspirin: increase adverse effects.Diuretics: reduce the natriuretic effect of Furosemide and Thiazides.Methotrexate: enhance the toxicity of Methotrexate.Warfarin: increase the risk of GI bleeding.Selective Serotonin Reuptake Inhibitors (SSRI): increase the risk of GI bleeding.

Contraindications

Naproxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Side Effects of Nipoxen SR 500 mg

Most frequently reported side effects include following: Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia. Central Nervous System: Headache, vertigo, drowsiness. Dermatological: Pruritus (itching), purpura. Cardiovascular: Edema, palpitation. Others: Visual disturbances, hearing disturbances.

Pregnancy & Lactation

US FDA pregnancy category of Naproxen is C. So, Naproxen should be avoided in pregnancy & lactation unless the potential benefits to the other outweigh the possible risks to the fetus.

Storage Conditions

Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.

Drug Classes

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Mode Of Action

Naproxen is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic & antipyretic properties. It is rapidly absorbed from the gastrointestinal tract and achieves 95% bioavailability.

Pregnancy

US FDA pregnancy category of Naproxen is C. So, Naproxen should be avoided in pregnancy & lactation unless the potential benefits to the other outweigh the possible risks to the fetus.

Frequently Asked Questions

What is Nipoxen SR 500 mg used for?

Naproxen is indicated for the relief of sign and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis & acute gout. It is also indicated for the management of primary dysmenorrhea & pain.

What is the dosage of Nipoxen SR 500 mg?

Naproxen Tablet- Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis: The usual dose is 500-1000 mg daily in two divided doses after meals. Management of pain, primary dysmenorrhea, acute tendonitis & bursitis: Recommended starting dose is 500 mg followed by 500 mg every 12 hours or 250 mg every 6-8 hours. The initial total daily dose should not exceed 1250 mg and thereafter, the total…

What are the side effects of Nipoxen SR 500 mg?

Who should not take Nipoxen SR 500 mg?

Is Nipoxen SR 500 mg safe during pregnancy and breastfeeding?

US FDA pregnancy category of Naproxen is C. So, Naproxen should be avoided in pregnancy & lactation unless the potential benefits to the other outweigh the possible risks to the fetus.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.