Nodia10 mg

Nodia 10 mg is indicated in adults for the treatment of active rheumatoid arthritis (RA) to reduce signs and symptoms and to retard structural damage as manifested by x-ray erosions and joint space narrowing.

Drugs used for Rheumatoid Arthritis

Nodia 10 mg is an isoxazole immunomodulatory agent which inhibits de novo pyrimidine synthesis and has anti-proliferative activity. Following oral administration, it is rapidly metabolized to A771726, which is active in vitro and is presumed to be the active drug in vivo. Nodia 10 mg has demonstrated prophylactic and therapeutic effects in animal models of autoimmune disease. In addition, Nodia 10 mg has exhibited anti-inflammatory and weak analgesic and antipyretic activity. In a model of experimental septicemia, Nodia 10 mg did not alter the resistance of mice to bacterial pathogens.

Nodia 10 mg once-daily oral dosing for rheumatoid arthritis patients. After a loading dose of 100 mg once daily for 3 days, the maintenance dose is 20 mg once daily. Nodia 10 mg does not require step wise dose increment over time. The dose may be decreased to 10 mg daily if tolerability issues arise.

Nodia 10 mg once-daily oral dosing for rheumatoid arthritis patients. After a loading dose of 100 mg once daily for 3 days, the maintenance dose is 20 mg once daily. Nodia 10 mg does not require step wise dose increment over time. The dose may be decreased to 10 mg daily if tolerability issues arise.

Cholestyramine and activated charcoal may decrease plasma concentration of active metabolite. Concurrent use of methotrexate and other hepatotoxic drugs may increase the risk of hepatotoxicity. Rifampicin increases serum levels of the active metabolite.

Nodia 10 mg is contraindicated in patients with known hypersensitivity to Nodia 10 mg or any of the other components of Nodia 10 mg, hepatic impairment, severe uncontrolled infections and bone marrow dysplasia.

Adverse reactions associated with the use of Nodia 10 mg include diarrhea, nausea, vomiting, abdominal pain, headache, respiratory infection, bronchitis, elevated liver enzymes, aggravation of pre-existing hypertension, alopecia, and rash.

Nodia 10 mg is not recommended for pregnant women. Pregnancy must be avoided during Nodia 10 mg treatment or prior to the completion of the drug elimination procedure after Nodia 10 mg treatment. Nodia 10 mg should not be used by nursing mothers. It is not known whether Nodia 10 mg is excreted in human milk. Many drugs are excreted in human milk and there is a potential for serious adverse reactions in nursing infants from Nodia 10 mg. Therefore, a decision should be made whether to proceed with nursing or initiate treatment with Nodia 10 mg, taking into account the importance of the drug to the mother.

Caution should be taken for those female with child bearing potential who are not using reliable contraception and for the subject of renal insufficiency. Nodia 10 mg should be stopped before becoming pregnant. Liver function should be monitored before starting treatment.

There is no human experience regarding Nodia 10 mg over dosage. In the event of a significant overdose or toxicity, cholestyramine or charcoal administration is recommended to accelerate elimination.

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Drugs used for Rheumatoid Arthritis

Nodia 10 mg is an isoxazole immunomodulatory agent which inhibits de novo pyrimidine synthesis and has anti-proliferative activity. Following oral administration, it is rapidly metabolized to A771726, which is active in vitro and is presumed to be the active drug in vivo. Nodia 10 mg has demonstrated prophylactic and therapeutic effects in animal models of autoimmune disease. In addition, Nodia 10 mg has exhibited anti-inflammatory and weak analgesic and antipyretic activity. In a model of experimental septicemia, Nodia 10 mg did not alter the resistance of mice to bacterial pathogens.

Nodia 10 mg is not recommended for pregnant women. Pregnancy must be avoided during Nodia 10 mg treatment or prior to the completion of the drug elimination procedure after Nodia 10 mg treatment. Nodia 10 mg should not be used by nursing mothers. It is not known whether Nodia 10 mg is excreted in human milk. Many drugs are excreted in human milk and there is a potential for serious adverse reactions in nursing infants from Nodia 10 mg. Therefore, a decision should be made whether to proceed with nursing or initiate treatment with Nodia 10 mg, taking into account the importance of the drug to the mother.