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Obactin0.3%
Eye/Ear Drop
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Medicine overview
Indications of Obactin 0.3%
pneumonia. Gastrointestinal Tract: Enteric feverpneumonia. Gastrointestinal Tract: Enteric feverkeratitiskerato-conjunctivitisblepharo-conjunctivitisblepharitis
Theropeutic Class
4-Quinolone preparations, Aural Anti-bacterial preparations
Pharmacology
Obactin 0.3% is a synthetic 4-fluoroquinolone antibacterial agent with bactericidal activity against a wide range of Gram-negative and Gram-positive organisms.
Absorption
Obactin 0.3% is thought to exert bactericidal effect by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication, transcription and repair of bacterial DNA.
Dosage of Obactin 0.3%
General dosage recommendations
Dosage:The dose of Obactin 0.3% is determined by the type and severity of the infection
Notes:The dosage range for adults is 200 mg to 800 mg daily. Up to 400 mg may be given as a single dose, preferably in the morning, larger doses should be given as two divided doses. Obactin 0.3% tablets should be swallowed with liquid; they should not be taken within two hours of intake of magnesium/aluminium containing antacids or iron preparations since reduction of absorption of Obactin 0.3% can occur
Enteric fever
Dosage:For adults 200 mg, every 12 hours, for 5 days
Notes:For children 15 mg/kg/day in 2 divided doses for 3 days
Shigellosis
Dosage:400 mg single dose
Multi-drug-resistant tuberculosis
Dosage:400 mg twice daily along with conventional anti-tuberculosis drugs
Lower respiratory tract infection
Dosage:400 mg daily, increasing, if necessary, to 400 mg twice daily
Uncomplicated Urinary Tract Infections
Dosage:A single dose of 200/400 mg
Uncomplicated urethral and cervical gonorrhoea
Dosage:A single dose of 400 mg
Non-gonococcal urethral and cervicitis
Dosage:400 mg daily in single or divided doses
Complicated Urinary Tract Infection
Dosage:200/400 mg/day for 7 days
Impaired liver function
Dosage:The excretion of Obactin 0.3% may be reduced inpatients with severe hepatic dysfunction
Children
Dosage:Obactin 0.3% is usually not indicated for use in children or growing adolescents
Elderly
Dosage:No adjustment of dosage is required in the elderly
Obactin 0.3% Eye & Ear Drops- Eye
Dosage:Instill 1 drop in the affected eye(s) every 2 to 4 hours for the first two days and then 4 times daily
Notes:The length of treatment should not exceed ten days
Ear
Dosage:Instill 1-2 drops in the affected ear(s) twice daily or as needed
| Condition | Dosage | Notes |
|---|---|---|
| General dosage recommendations | The dose of Obactin 0.3% is determined by the type and severity of the infection | The dosage range for adults is 200 mg to 800 mg daily. Up to 400 mg may be given as a single dose, preferably in the morning, larger doses should be given as two divided doses. Obactin 0.3% tablets should be swallowed with liquid; they should not be taken within two hours of intake of magnesium/aluminium containing antacids or iron preparations since reduction of absorption of Obactin 0.3% can occur |
| Enteric fever | For adults 200 mg, every 12 hours, for 5 days | For children 15 mg/kg/day in 2 divided doses for 3 days |
| Shigellosis | 400 mg single dose | |
| Multi-drug-resistant tuberculosis | 400 mg twice daily along with conventional anti-tuberculosis drugs | |
| Lower respiratory tract infection | 400 mg daily, increasing, if necessary, to 400 mg twice daily | |
| Uncomplicated Urinary Tract Infections | A single dose of 200/400 mg | |
| Uncomplicated urethral and cervical gonorrhoea | A single dose of 400 mg | |
| Non-gonococcal urethral and cervicitis | 400 mg daily in single or divided doses | |
| Complicated Urinary Tract Infection | 200/400 mg/day for 7 days | |
| Impaired liver function | The excretion of Obactin 0.3% may be reduced inpatients with severe hepatic dysfunction | |
| Children | Obactin 0.3% is usually not indicated for use in children or growing adolescents | |
| Elderly | No adjustment of dosage is required in the elderly | |
| Obactin 0.3% Eye & Ear Drops- Eye | Instill 1 drop in the affected eye(s) every 2 to 4 hours for the first two days and then 4 times daily | The length of treatment should not exceed ten days |
| Ear | Instill 1-2 drops in the affected ear(s) twice daily or as needed |
Administration of Obactin 0.3%
May be taken with or without food. Avoid antacids or supplements containing Fe or Zn within 2 hr before or after Obactin 0.3%. Ensure adequate hydration.
Interaction of Obactin 0.3%
Antacids containing magnesium, aluminium or calcium may decrease absorption of Obactin 0.3%. Iron or Zinc may decrease oral absorption of Obactin 0.3%.
Contraindications
Obactin 0.3% should not be used in-patients with known hypersensitivity to 4-fluoroquinolone antibacterials. It is contraindicated in-patients with a history of epilepsy or with a lowered seizure threshold. Obactin 0.3% is usually contraindicated in children or growing adolescents and in pregnant or breast feeding women.
Side Effects of Obactin 0.3%
Obactin 0.3% tablet is generally well tolerated and clinical side-effects of Obactin 0.3% has been quite low. Among the adverse effects gastrointestinal and central nervous systems' reactions are common. Nausea, rash, vomiting, abdominal pain, diarrhoea and gastrointestinal distress are the gastrointestinal adverse effects. Common central nervous system reactions are headache, dizziness and insomnia.Eye: Transient ocular irritation, burning, stinging, redness, itching or photophobia have been reported.Ear: Mild irritation or mild discomfort in the ear may occur. Symptoms of an allergic reaction include rash, itching, swelling or trouble breathing.
Pregnancy & Lactation
The safety of Obactin 0.3% during pregnancy has not been established. Obactin 0.3% may enter breast milk but data are not available.
Precautions & Warnings
Patients being treated with Obactin 0.3% should not expose themselves unnecessarily to strong sunlight and should avoid UV rays. Caution is recommended if the drug is to be used in psychotic patients or in-patients with a history of psychiatric disease.Prolonged use of eye drops & ear drops may result in overgrowth of non-susceptible organisms and secondary infection respectively.
Overdose Effects of Obactin 0.3%
Symptoms: Confusion, dizziness, impairment of consciousness, convulsive seizures, GI reactions (e.g. nausea, mucosal erosions). Management: Symptomatic and supportive treatment. Remove any unabsorbed drug by gastric lavage or admin of adsorbants and Na sulfate. Antacids are recommended for protection of gastric mucosa. Elimination may be increased by forced diuresis.
Storage Conditions
Store between 15-30°C. Protect from light.
Use In Special Populations
Renal Impairment:
CrCl <20 and patients on haemodialysis or peritoneal dialysis: 100 mg 24 hrly following usual initial dose.
CrCl 20-50: Reduce dose by half 24 hrly following usual initial dose.
Hepatic Impairment:Severe: Reduce dose. Max: 400 mg daily
Drug Classes
4-Quinolone preparations, Aural Anti-bacterial preparations
Mode Of Action
Obactin 0.3% containing Obactin 0.3% is a synthetic 4-fluoroquinolone antibacterial agent with bactericidal activity against a wide range of Gram-negative and Gram-positive organisms. Obactin 0.3% is thought to exert bactericidal effect by inhibiting DNA gyrase, an essential enzyme that is a critical catalyst in the duplication, transcription and repair of bacterial DNA. Following oral administration Obactin 0.3% is rapidly and well absorbed from G.I. tract. The bioavailability of Obactin 0.3% in the tablet formulation is almost 100%. It is widely distributed into body tissues and fluid. The half-life is about 4.6 to 6.9 hours. Up to 80% of an oral dose of Obactin 0.3% is eliminated in the urine as the parent compound within 48 hour.
Pregnancy
The safety of Obactin 0.3% during pregnancy has not been established. Obactin 0.3% may enter breast milk but data are not available.
Frequently Asked Questions
What is Obactin 0.3% used for?
Ofloxacin tablets are indicated for the treatment of adults with mild to moderate infections caused by susceptible strains. Lower Respiratory Tract: Acute bacterial exacerbation of chronic bronchitis lung abscess, pneumonia. Gastrointestinal Tract: Enteric fever, shigellosis. ... Read moreOfloxacin tablets are indicated for the treatment of adults with mild to moderate infections caused by suscept…
What is the dosage of Obactin 0.3%?
General dosage recommendations: The dose of ofloxacin is determined by the type and severity of the infection. The dosage range for adults is 200 mg to 800 mg daily. Up to 400 mg may be given as a single dose, preferably in the morning, larger doses should be given as two divided doses. Ofloxacin tablets should be swallowed with liquid; they should not be taken within two hours of intake of magnes…
What are the side effects of Obactin 0.3%?
Ofloxacin tablet is generally well tolerated and clinical side-effects of ofloxacin has been quite low. Among the adverse effects gastrointestinal and central nervous systems' reactions are common. Nausea, rash, vomiting, abdominal pain, diarrhoea and gastrointestinal distress are the gastrointestinal adverse effects. Common central nervous system reactions are headache, dizziness and insomnia.Eye…
Who should not take Obactin 0.3%?
Ofloxacin should not be used in-patients with known hypersensitivity to 4-fluoroquinolone antibacterials. It is contraindicated in-patients with a history of epilepsy or with a lowered seizure threshold. Ofloxacin is usually contraindicated in children or growing adolescents and in pregnant or breast feeding women.
What precautions should be taken with Obactin 0.3%?
Patients being treated with Ofloxacin should not expose themselves unnecessarily to strong sunlight and should avoid UV rays. Caution is recommended if the drug is to be used in psychotic patients or in-patients with a history of psychiatric disease.Prolonged use of eye drops & ear drops may result in overgrowth of non-susceptible organisms and secondary infection respectively.
Is Obactin 0.3% safe during pregnancy and breastfeeding?
The safety of ofloxacin during pregnancy has not been established. Ofloxacin may enter breast milk but data are not available.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.