Oculogen

Oculogen0.005%+0.02%

Ophthalmic Solution

Naphazoline + Zinc Sulfate

General Pharmaceuticals Ltd.

Product Code : 12193
MRP 80.24
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Medicine overview

Indications of Oculogen 0.005%+0.02%

Acute and chronic non-infectious conjunctivitis, nonspecific conjunctival irritation; also after successful treatment of bacterial and viral conjunctivitis. Irrigation of the tear ducts.

Theropeutic Class

Ophthalmic Non-Steroid drugs

Pharmacology

Zinc ions, the active compound of zinc sulphate, have an astringent, i.e. tissue-sealing and slightly anti-septic effect. Naphazoline constricts the blood vessels and reduces the inflammation and swelling of the conjunctiva. This effect of naphazoline, a substance of the benzylimidazoline group, is due to direct binding to a-adrenergic receptor sites on unstriated muscle cells in the blood vessels.

Dosage & Administration of Oculogen 0.005%+0.02%

Adults: 1 drop in the conjunctival sac, three to 4 times per day.Children: Naphazoline nitrate and Zinc sulphate drops has not been studied in children. Generally, in children the dosage of vasoconstrictors should be low and selected with caution.

Dosage of Oculogen 0.005%+0.02%

Adults: 1 drop in the conjunctival sac, three to 4 times per day.Children: Naphazoline nitrate and Zinc sulphate drops has not been studied in children. Generally, in children the dosage of vasoconstrictors should be low and selected with caution.

Interaction of Oculogen 0.005%+0.02%

Naphazoline containing products should not be administered during treatment with MAO-blockers nor during 10 days after discontinuation of such treatment. The effects of Naphazoline may be increased by concomitant use of tricyclic antidepressants.

Contraindications

Hypersensitivity to zinc sulphate, Naphazoline and other ingredients. Naphazoline & Zinc is contraindicated in patients suffering from narrow-angle glaucoma, dry eye and especially keratoconjunctivits sicca Sjogren's syndrome. Naphazoline & Zinc must not be used in infants.

Side Effects of Oculogen 0.005%+0.02%

Mydriasis and a slight increase of intraocular pressure in isolated cases. A slight and transient burning sensation may occur after instillation, which does not affect the success of the treatment. Long term use may result in reactive redness of the eye (rebound effect).In very rare cases systemic cardiovascular effects, such as hypertension and arrhythmia, may occur. Nonspecific fatigue has been observed in some patients.

Pregnancy & Lactation

Use in pregnancy: There are neither controlled animal studies nor studies in pregnant women available.Use in lactation: The effects of Naphazoline & Zinc treatment during lactation have not been investigated.

Precautions & Warnings

Uncontrolled use of Naphazoline & Zinc over extended periods of time should be avoided. If no improvement is seen after 2 days, treatment should be discontinued and other therapeutic measures should be considered. If ocular discomfort or visual disturbance occurs during Naphazoline & Zinc treatment, the therapy must be discontinued. Caution is indicated in patients with predisposition to glaucoma and in patients suffering from hypertension, cardiovascular diseases, pheochromocytoma, aneurysm, hyperglycemia, and hyperthyroidism.

Drug Classes

Ophthalmic Non-Steroid drugs

Mode Of Action

Zinc ions, the active compound of zinc sulphate, have an astringent, i.e. tissue-sealing and slightly anti-septic effect. Naphazoline constricts the blood vessels and reduces the inflammation and swelling of the conjunctiva. This effect of naphazoline, a substance of the benzylimidazoline group, is due to direct binding to a-adrenergic receptor sites on unstriated muscle cells in the blood vessels.

Pregnancy

Use in pregnancy: There are neither controlled animal studies nor studies in pregnant women available.Use in lactation: The effects of Naphazoline & Zinc treatment during lactation have not been investigated.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.