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Oragon150 mg
Renata Limited
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Orili150 mg
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Medicine overview
Indications of Orili 150 mg
Elagolix is indicated for the management of moderate to severe pain associated with endometriosis.
Dosage of Orili 150 mg
Route of Administration
Dosage:Should be taken orally
Dosage
Dosage:Pregnancy should be excluded before starting Elagolix and starting Elagolix within 7 days from the onset of menses
Notes:Elagolix should be taken at approximately the same time each day, with or without food. Lowest effective dose, taking into account the severity of symptoms and treatment objectives. Initial treatment with Elagolix 150 mg once daily up to 24 months. But in case of moderate hepatic impairment up to 6 months
Use in children and adolescents
Dosage:<18 years not established
| Condition | Dosage | Notes |
|---|---|---|
| Route of Administration | Should be taken orally | |
| Dosage | Pregnancy should be excluded before starting Elagolix and starting Elagolix within 7 days from the onset of menses | Elagolix should be taken at approximately the same time each day, with or without food. Lowest effective dose, taking into account the severity of symptoms and treatment objectives. Initial treatment with Elagolix 150 mg once daily up to 24 months. But in case of moderate hepatic impairment up to 6 months |
| Use in children and adolescents | <18 years not established |
Interaction of Orili 150 mg
With medicine: May potentiate P-gp substrates (e.g. digoxin), CYP2C19 substrates (e.g. omeprazole; limit doses to <40 mg daily). May antagonize CYP3A substrates. Antagonizes oral midazolam, rosuvastatin; consider increasing their doses. May be antagonized by CYP3A inducers. Reduced efficacy with estrogen-containing contraceptives.With food and others: No known food interaction.
Contraindications
It is contraindicated in pregnant women because exposure to Elagolix early in pregnancy may increase the risk of early pregnancy loss. With known osteoporosis, it can increase the risk of further bone loss. It is also contraindicated for severe hepatic impairment and also with concomitant use of strong organic anion transporting polypeptide OATP1B1 inhibitors (e.g. cyclosporine and gemfibrozil).
Side Effects of Orili 150 mg
Common (>1%)
- Common: The most common side effects include hot flushes
- night sweats
- headache
Uncommon
- nausea
- amenorrhea
- arthralgia
Rare / Long-term
- mood changes & bone loss. Rare: Insomnia
- anxiety & elevated hepatic transaminase.
Precautions & Warnings
Bone Loss: Dose and duration-dependent decreases in bone mineral density (BMD) that may not be completely reversible. Assess BMD in women with additional risk factors for bone loss.Reduced Ability to Recognize Pregnancy: Elagolix may alter menstrual bleeding, which may reduce the ability to recognize pregnancy. Perform testing if pregnancy is suspected. Discontinue if pregnancy is confirmed.Suicidal Ideation and Mood Disorders: Advise patients to seek medical attention for suicidal ideation, suicidal behavior, new onset or worsening depression, anxiety, or other mood changes.Hepatic Transaminase Elevations: Dose-dependent elevations in serum alanine aminotransferase (ALT). Counsel patients on signs and symptoms of liver injury.Potential for Reduced Efficacy with Estrogen-Containing Contraceptives: Use non-hormonal contraception during treatment and for one week after discontinuing Elagolix.
Overdose Effects of Orili 150 mg
In case of overdose, patients should be monitored for any signs or symptoms of adverse reactions and initiate appropriate symptomatic treatment, as needed.
Storage Conditions
Store in a cool & dry place, protect from light & moisture. Keep all medicines out of reach of children.
Drug Classes
Gonadotropin-releasing hormone (GnRH) antagonist
Mode Of Action
Elagolix is a GnRH receptor antagonist that inhibits endogenous GnRH signaling by binding competitively to GnRH receptors in the pituitary gland.
Absorption
Administration of Elagolix results in dose-dependent suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to decreased blood concentrations of the ovarian sex hormones, estradiol and progesterone.
Pregnancy
The limited human data with the use of Elagolix in pregnant women are insufficient to determine whether there is a risk for major birth defects or miscarriage. Exposure to Elagolix early in pregnancy may increase the risk of early pregnancy loss. Use of it is contraindicated in pregnant women. Elagolix has to be discontinued if pregnancy occurs during treatment. There is no information on the presence of elagolix or its metabolites in human milk, the effects on the breastfed child or the effects on milk production.
Pediatric Uses
No dose adjustment of Elagolix is required in women with any degree of renal impairment or end-stage renal disease (including women on dialysis)
No dosage adjustment of Elagolix is required in women with mild hepatic impairment.
Safety and effectiveness of Elagolix in patients less than 18 years of age have not been established.
Frequently Asked Questions
What is Orili 150 mg used for?
Elagolix is indicated for the management of moderate to severe pain associated with endometriosis.
What is the dosage of Orili 150 mg?
Route of Administration: Should be taken orally.Dosage: Pregnancy should be excluded before starting Elagolix and starting Elagolix within 7 days from the onset of menses. Elagolix should be taken at approximately the same time each day, with or without food. Lowest effective dose, taking into account the severity of symptoms and treatment objectives. Initial treatment with Elagolix 150 mg once da…
What are the side effects of Orili 150 mg?
Common: The most common side effects include hot flushes, night sweats, headache, nausea, amenorrhea, , arthralgia, mood changes & bone loss. Rare: Insomnia, anxiety & elevated hepatic transaminase.
Who should not take Orili 150 mg?
It is contraindicated in pregnant women because exposure to Elagolix early in pregnancy may increase the risk of early pregnancy loss. With known osteoporosis, it can increase the risk of further bone loss. It is also contraindicated for severe hepatic impairment and also with concomitant use of strong organic anion transporting polypeptide OATP1B1 inhibitors (e.g. cyclosporine and gemfibrozil).
What precautions should be taken with Orili 150 mg?
Bone Loss: Dose and duration-dependent decreases in bone mineral density (BMD) that may not be completely reversible. Assess BMD in women with additional risk factors for bone loss.Reduced Ability to Recognize Pregnancy: Elagolix may alter menstrual bleeding, which may reduce the ability to recognize pregnancy. Perform testing if pregnancy is suspected. Discontinue if pregnancy is confirmed.Suicid…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.