Palopag200 mg

Name: Palopag 200 mg
Brand: Palopag
Price: 135.00 BDT
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Medicine overview

Indications of Palopag 200 mg

Palopag 200 mg is indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization for PAH.

Dosage of Palopag 200 mg

The recommended starting dose is 200 mcg twice daily. Tolerability may be improved when taken with food. Increase the dose by 200 mcg twice daily at weekly intervals to the highest tolerated dose up to 1600 mcg twice daily. The maintenance dose is determined by tolerability.Pediatric use: Safety and effectiveness in pediatric patients have not been established.Geriatric use: No overall differences have been observed.Hepatic impairment: For Moderate hepatic impairment patients starting dose is 200 mcg once daily, increase the dose by 200 mcg once daily at weekly intervals to the highest tolerated dose up to 1600 mcg. Avoid use of Palopag 200 mg in patients with severe hepatic impairment (Child-Pugh class C).

Interaction of Palopag 200 mg

Moderate CYP2C8 inhibitors (e.g., deferasirox and teriflunomide) may increase exposure to the active metabolite of Palopag 200 mg: CYP2C8 inducers (e.g., rifampicin) decrease exposure to the active metabolite & Increase concentration up to twice the dose of Palopag 200 mg

Side Effects of Palopag 200 mg

The most common side-effects of Palopag 200 mg are Nausea, Diarrhoea, Vomiting, Headache, Jaw pain, muscle pain, low appetite and low RBC count.

Precautions & Warnings

Discontinue Palopag 200 mg if the patient develops the sign and symptoms of Pulmonary Veno-Occlusive Disease (PVOD)

Overdose Effects of Palopag 200 mg

Isolated cases of overdose up to 3200 mcg were reported. Mild transient nausea was the only reported consequence. In the event of overdose, supportive measures must be taken as required.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of reach of children.

Drug Classes

Non-prostanoid IP prostacyclin receptor agonist

Mode Of Action

Palopag 200 mg is a selective non-prostanoid IP prostacyclin receptor agonist. Palopag 200 mg is a pale yellow crystalline powder that is practically insoluble in water. In the solid-state Palopag 200 mg is very stable, is not hygroscopic, and is not light sensitive. Palopag 200 mg is an oral prostacyclin receptor (IP receptor) agonist that is structurally distinct from prostacyclin. Palopag 200 mg is hydrolyzed by carboxylesterase 1 to yield its active metabolite, which is approximately 37-fold as potent as Palopag 200 mg. Palopag 200 mg and the active metabolite are selective for the IP receptor versus other prostanoid receptors (EP1-4, DP, FP, and TP).

Pregnancy

There are no adequate and well controlled studies with Palopag 200 mg in pregnant women It is not known if Palopag 200 mg is present in human milk. Palopag 200 mg or breastfeeding should be discontinued in nursing mother.

Frequently Asked Questions

What is Palopag 200 mg used for?

Palopag 200 mg is indicated for the treatment of pulmonary arterial hypertension (PAH, WHO Group I) to delay disease progression and reduce the risk of hospitalization for PAH.

What is the dosage of Palopag 200 mg?

What are the side effects of Palopag 200 mg?