Prostol1 mg
Capsule
Medicine overview
Indications of Prostol 1 mg
Theropeutic Class
Pharmacology
Terazosin is an α1-adrenoceptor antagonist which blocks peripheral postsynaptic receptors resulting to decreased arterial tone.
It relaxes smooth muscle of the bladder neck causing a reduction of bladder outlet obstruction. In general, α1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. α1-Receptors are 7-transmembrane domain receptors coupled to G proteins, Gq/11.
Three α1-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: α1A (chromosome 8), α1B (chromosome 5), and α1D (chromosome 20). Terazosin is the first α1-receptor antagonist to demonstrate selectivity for the α1A-receptor. All three receptor subtypes appear to be involved in maintaining vascular tone.
The α1A-receptor maintains basal vascular tone while the α1B-receptor mediates the vasocontrictory effects of exogenous α1-agonists. Activation of α1-receptors activates Gq-proteins, which results in intracellular stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2+ from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and subsequent vasoconstriction.
Inhibition of these receptors in the vasculature and prostate results in muscle relaxation, decreased blood pressure and improved urinary outflow in symptomatic benign prostatic hyperplasia.
Dosage & Administration of Prostol 1 mg
| Condition | Dosage | Notes |
|---|---|---|
| Benign Prostatic Hyperplasia | Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded | |
| Subsequent dose | The dose slowly increases to achieve the desired response | The usual recommended dose range is 5-10 mg administered once a day |
| Hypertension | Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded | |
| Subsequent dose | The dose slowly increases to achieve the desired response | The usual recommended dose range is 2-10 mg administered once a day |
Dosage of Prostol 1 mg
| Condition | Dosage | Notes |
|---|---|---|
| Benign Prostatic Hyperplasia- Initial dose | 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded | |
| Subsequent dose | The dose slowly increases to achieve the desired response | The usual recommended dose range is 5-10 mg administered once a day |
| Hypertension- Initial dose | 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded | |
| Subsequent dose | The dose slowly increases to achieve the desired response | The usual recommended dose range is 2-10 mg administered once a day |
Interaction of Prostol 1 mg
Contraindications
Side Effects of Prostol 1 mg
Pregnancy & Lactation
Precautions & Warnings
Overdose Effects of Prostol 1 mg
Storage Conditions
Drug Classes
Mode Of Action
Pregnancy
Frequently Asked Questions
What is Prostol 1 mg used for?
Terazosin Hydrochloride is indicated in- Single therapy is used to relieve from signs and symptoms of benign prostatic hyperplasia (BPH). For the treatment of hypertension.
What is the dosage of Prostol 1 mg?
Benign Prostatic Hyperplasia- Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequent dose: The dose slowly increases to achieve the desired response. The usual recommended dose range is 5-10 mg administered once a day. Hypertension- Initial dose: 1 mg at bedtime is starting dose of all patients and this dose should not be exceeded. Subsequen…
What are the side effects of Prostol 1 mg?
Postural hypotension is more commonly reported side effect. Dizziness, lack of energy, peripheral oedema; urinary frequency and priapism reported.
Who should not take Prostol 1 mg?
Terazosin is contraindicated in patients known to be hypersensitive to Terazosin or its analogues.
What precautions should be taken with Prostol 1 mg?
First dose may cause hypotension (within 30-90 minutes). Therefore should be taken on retiring to bed. Caution should be observed when Terazosin is administered with other antihypertensive agents, avoid the possibility of significant hypotension. When adding Terazosin to a diuretic or other antihypertensive agent, dosage reduction and retitration may be necessary. The patients should be cautioned …
Is Prostol 1 mg safe during pregnancy and breastfeeding?
The safety of Terazosin during pregnancy has not been established so Terazosin is not recommended during pregnancy unless the potential benefit justifies the potential risk to moher and fetus. It is not known whether Terazosin is excreted in breast milk. Because many drugs are excreted in breast milk, caution should be exercised when Terazosn is administered to a nursing mother.
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.