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Purinol300 mg
Drug International Ltd.
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Purinol300 mg
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Medicine overview
Indications of Purinol 300 mg
skin tophinephrolithiasis). Purinol 300 mg is indicated for management of 28-dihydroxyadenine (2skin tophinephrolithiasis). Purinol 300 mg is indicated for management of 28-dihydroxyadenine (2when fluiddietary and similar measures have failed.
Theropeutic Class
Drugs used in Gout
Pharmacology
Purinol 300 mg is a xanthine oxidase inhibitor which is administered orally.
Absorption
Purinol 300 mg is approximately 90% absorbed from the GI tract. Peak plasma levels generally occur at 1.5 hours to 4.5 hours.
Metabolism
It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and xanthine to uric acid, the end product of purine metabolism. It has a plasma half life of about 1 to 2 hours.
Excretion
It acts on purine catabolism without disrupting the biosynthesis of purines. Purinol 300 mg is a structural analogue of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and xanthine to uric acid, the end product of purine metabolism. Purinol 300 mg is approximately 90% absorbed from the GI tract. Approximately 20% of the ingested Purinol 300 mg is excreted in the faeces.
Dosage & Administration of Purinol 300 mg
Adults
Dosage:Purinol 300 mg should be introduced at low dosage e
Notes:100mg/day to reduce the risk of adverse reactions and increased only if the serum urate response is unsatisfactory. Extra caution should be exercised if renal function is poor
The following dosage schedules are suggested
Dosage:100 to 200 mg daily in mild conditions, 300 to 600 mg daily in moderately severe conditions, 700 to 900 mg daily in severe conditions
Children
Dosage:Children under 15 years: 10 to 20 mg/kg body weight/day up to a maximum of 400 mg daily
Notes:Use in children is rarely indicated, except in malignant conditions (especially leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome
Elderly
Dosage:In the absence of specific data, the lowest dosage which produces satisfactory urate reduction should be used
Dosage in renal impairment
Dosage:In severe renal insufficiency, it may be advisable to use less than 100 mg per day or to use single doses of 100mg at longer intervals than one day
| Condition | Dosage | Notes |
|---|---|---|
| Adults | Purinol 300 mg should be introduced at low dosage e | 100mg/day to reduce the risk of adverse reactions and increased only if the serum urate response is unsatisfactory. Extra caution should be exercised if renal function is poor |
| The following dosage schedules are suggested | 100 to 200 mg daily in mild conditions, 300 to 600 mg daily in moderately severe conditions, 700 to 900 mg daily in severe conditions | |
| Children | Children under 15 years: 10 to 20 mg/kg body weight/day up to a maximum of 400 mg daily | Use in children is rarely indicated, except in malignant conditions (especially leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome |
| Elderly | In the absence of specific data, the lowest dosage which produces satisfactory urate reduction should be used | |
| Dosage in renal impairment | In severe renal insufficiency, it may be advisable to use less than 100 mg per day or to use single doses of 100mg at longer intervals than one day |
Dosage of Purinol 300 mg
Adults
Dosage:Purinol 300 mg should be introduced at low dosage e
Notes:100mg/day to reduce the risk of adverse reactions and increased only if the serum urate response is unsatisfactory. Extra caution should be exercised if renal function is poor
The following dosage schedules are suggested
Dosage:100 to 200 mg daily in mild conditions, 300 to 600 mg daily in moderately severe conditions, 700 to 900 mg daily in severe conditions
Children
Dosage:Children under 15 years: 10 to 20 mg/kg body weight/day up to a maximum of 400 mg daily
Notes:Use in children is rarely indicated, except in malignant conditions (especially leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome
Elderly
Dosage:In the absence of specific data, the lowest dosage which produces satisfactory urate reduction should be used
Dosage in renal impairment
Dosage:In severe renal insufficiency, it may be advisable to use less than 100 mg per day or to use single doses of 100mg at longer intervals than one day
| Condition | Dosage | Notes |
|---|---|---|
| Adults | Purinol 300 mg should be introduced at low dosage e | 100mg/day to reduce the risk of adverse reactions and increased only if the serum urate response is unsatisfactory. Extra caution should be exercised if renal function is poor |
| The following dosage schedules are suggested | 100 to 200 mg daily in mild conditions, 300 to 600 mg daily in moderately severe conditions, 700 to 900 mg daily in severe conditions | |
| Children | Children under 15 years: 10 to 20 mg/kg body weight/day up to a maximum of 400 mg daily | Use in children is rarely indicated, except in malignant conditions (especially leukaemia) and certain enzyme disorders such as Lesch-Nyhan syndrome |
| Elderly | In the absence of specific data, the lowest dosage which produces satisfactory urate reduction should be used | |
| Dosage in renal impairment | In severe renal insufficiency, it may be advisable to use less than 100 mg per day or to use single doses of 100mg at longer intervals than one day |
Interaction of Purinol 300 mg
When 6-mercaptopurine or azathioprine is given concurrently with Purinol 300 mg, only one-quarter of the usual dose of 6- mercaptopurine or azathioprine should be given because inhibition of xanthine oxidase will prolong their activity. Evidence suggests that the plasma half-life of vidarabine is increased in the presence of Purinol 300 mg. When the two products are used concomitantly extra vigilance is necessary, to recognise enhanced toxic effects. Theophylline levels should be monitored in patients starting or increasing Purinol 300 mg therapy. An increase in frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with Purinol 300 mg compared to patients who are not receiving both drugs. Reports suggest that the plasma concentration of ciclosporin may be increased during concomitant treatment with Purinol 300 mg.
Contraindications
Purinol 300 mg tablet is contra-indicated in patients with known hypersensitive to Purinol 300 mg.
Side Effects of Purinol 300 mg
Rashes, gastro intestinal disorder’s, rearly malaise, headache, vertigo, drowsiness, visual and test disturbances, hypertension, alopecia, hepatotoxicity, neuropathy, gynaeconastia and blood disorders.
Pregnancy & Lactation
There is inadequate evidence of safety of Purinol 300 mg in human pregnancy. Use in pregnancy only when there is no safer alternative and when the disease itself carries risk for the mother or unborn child. There are no data concerning the effects of Purinol 300 mg or its metabolites on the breast-feed baby.
Precautions & Warnings
Purinol 300 mg should be withdrawn immediately when a skin rash or other evidence of sensitivity occurs. Reduced doses should be used in patients with hepatic or renal impairment. Patients under treatment for hypertension or cardiac insufficiency may have some concomitant impairment of renal function and Purinol 300 mg should be used with care in this group.
Overdose Effects of Purinol 300 mg
Ingestion of up to 22.5 g Purinol 300 mg without adverse effect has been reported. Symptoms and signs including nausea, vomiting, diarrhoea and dizziness have been reported in a patient who ingested 20 gm Purinol 300 mg. Adequate hydration to maintain optimum diuresis facilitates excretion of Purinol 300 mg and its metabolites. If considered necessary haemodialysis may be used.
Storage Conditions
Store in a cool and dry place, protected from light.
Drug Classes
Drugs used in Gout
Mode Of Action
Purinol 300 mg is a xanthine oxidase inhibitor which is administered orally. It acts on purine catabolism without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation. Purinol 300 mg is a structural analogue of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and xanthine to uric acid, the end product of purine metabolism. Purinol 300 mg is approximately 90% absorbed from the GI tract. Peak plasma levels generally occur at 1.5 hours to 4.5 hours. It has a plasma half life of about 1 to 2 hours. Approximately 20% of the ingested Purinol 300 mg is excreted in the faeces.
Pregnancy
There is inadequate evidence of safety of Purinol 300 mg in human pregnancy. Use in pregnancy only when there is no safer alternative and when the disease itself carries risk for the mother or unborn child. There are no data concerning the effects of Purinol 300 mg or its metabolites on the breast-feed baby.
Frequently Asked Questions
What is Purinol 300 mg used for?
Allopurinol is indicated for reducing urate/uric acid formation in conditions where urate/uric acid deposition has already occurred (e.g. gouty arthritis, skin tophi, nephrolithiasis). Allopurinol is indicated for management of 2,8-dihydroxyadenine (2,8-DHA) renal stones related to deficient activity ... Read moreAllopurinol is indicated for reducing urate/uric acid formation in conditions where u…
What is the dosage of Purinol 300 mg?
Adults: Allopurinol should be introduced at low dosage e.g. 100mg/day to reduce the risk of adverse reactions and increased only if the serum urate response is unsatisfactory. Extra caution should be exercised if renal function is poor. The following dosage schedules are suggested: 100 to 200 mg daily in mild conditions, 300 to 600 mg daily in moderately severe conditions, 700 to 900 mg daily in s…
What are the side effects of Purinol 300 mg?
Rashes, gastro intestinal disorder’s, rearly malaise, headache, vertigo, drowsiness, visual and test disturbances, hypertension, alopecia, hepatotoxicity, neuropathy, gynaeconastia and blood disorders.
Who should not take Purinol 300 mg?
Allopurinol tablet is contra-indicated in patients with known hypersensitive to allopurinol.
What precautions should be taken with Purinol 300 mg?
Allopurinol should be withdrawn immediately when a skin rash or other evidence of sensitivity occurs. Reduced doses should be used in patients with hepatic or renal impairment. Patients under treatment for hypertension or cardiac insufficiency may have some concomitant impairment of renal function and allopurinol should be used with care in this group.
Is Purinol 300 mg safe during pregnancy and breastfeeding?
There is inadequate evidence of safety of Allopurinol in human pregnancy. Use in pregnancy only when there is no safer alternative and when the disease itself carries risk for the mother or unborn child. There are no data concerning the effects of allopurinol or its metabolites on the breast-feed baby.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.