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Rasagil0.5 mg
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Ralect0.5 mg
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Medicine overview
Indications of Ralect 0.5 mg
Ralect 0.5 mg is indicated for the treatment of the signs and symptoms of idiopathic Parkinson's disease as initial monotherapy, and as adjunct therapy to dopamine agonists or to levodopa.
Theropeutic Class
Antiparkinson drugs
Pharmacology
Ralect 0.5 mg is a potent, irreversible, selective MAO-B inhibitor that effectively crosses the blood brain barrier after oral administration.
Absorption
The precise mechanisms of action of Ralect 0.5 mg are unknown.
Distribution
One mechanism is believed to be related to its MAO-B inhibitory activity, which causes an increase in extracellular levels of dopamine in the brain.
Metabolism
The elevated dopamine level and subsequent increased dopaminergic activity are likely to mediate Ralect 0.5 mg's beneficial effects.
Dosage & Administration of Ralect 0.5 mg
Monotherapy
Dosage:Ralect 0.5 mg 1 mg once dailyAs adjunct without Levodopa: Ralect 0.5 mg 1 mg once dailyAs adjunct to Levodopa: Ralect 0.5 mg 0.5 mg once daily
| Condition | Dosage | Notes |
|---|---|---|
| Monotherapy | Ralect 0.5 mg 1 mg once dailyAs adjunct without Levodopa: Ralect 0.5 mg 1 mg once dailyAs adjunct to Levodopa: Ralect 0.5 mg 0.5 mg once daily |
Dosage of Ralect 0.5 mg
Monotherapy
Dosage:Ralect 0.5 mg 1 mg once dailyAs adjunct without Levodopa: Ralect 0.5 mg 1 mg once dailyAs adjunct to Levodopa: Ralect 0.5 mg 0.5 mg once daily
| Condition | Dosage | Notes |
|---|---|---|
| Monotherapy | Ralect 0.5 mg 1 mg once dailyAs adjunct without Levodopa: Ralect 0.5 mg 1 mg once dailyAs adjunct to Levodopa: Ralect 0.5 mg 0.5 mg once daily |
Interaction of Ralect 0.5 mg
Concomitant use of Ralect 0.5 mg with meperidine, dextromethorphan, antidepressants is not recommended.
Contraindications
Ralect 0.5 mg is contraindicated for use with meperidine, tramadol, methadone, propoxyphene and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors, because of risk of serotonin syndrome.
Side Effects of Ralect 0.5 mg
Common side effects of Ralect 0.5 mg include: dizziness, spinning sensation, joint pain, headache, heartburn, nausea, muscle pain etc.
Pregnancy & Lactation
Pregnancy Category C. Ralect 0.5 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. So, caution should be exercised when administered to a nursing woman.
Precautions & Warnings
Exacerbation of hypertension may occur during treatment with Ralect 0.5 mg. Medication adjustment may be necessary if elevation of blood pressure is sustained. Dose should not exceed 0.5 mg once daily for patients with mild hepatic impairment or taking concomitant Ciprofloxacin or other CYP1A2 inhibitors.
Storage Conditions
Store below 30° c, protected from light and moisture. Keep all the medicines out of reach of children.
Use In Special Populations
Pediatric use: The safety and effectiveness in pediatric patients have not been established.
Drug Classes
Antiparkinson drugs
Mode Of Action
Ralect 0.5 mg is a potent, irreversible, selective MAO-B inhibitor that effectively crosses the blood brain barrier after oral administration. The precise mechanisms of action of Ralect 0.5 mg are unknown. One mechanism is believed to be related to its MAO-B inhibitory activity, which causes an increase in extracellular levels of dopamine in the brain. The elevated dopamine level and subsequent increased dopaminergic activity are likely to mediate Ralect 0.5 mg's beneficial effects.
Pregnancy
Pregnancy Category C. Ralect 0.5 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. So, caution should be exercised when administered to a nursing woman.
Pediatric Uses
Pediatric use: The safety and effectiveness in pediatric patients have not been established.
Frequently Asked Questions
What is Ralect 0.5 mg used for?
Rasagiline is indicated for the treatment of the signs and symptoms of idiopathic Parkinson's disease as initial monotherapy, and as adjunct therapy to dopamine agonists or to levodopa.
What is the dosage of Ralect 0.5 mg?
Monotherapy: Rasagiline 1 mg once dailyAs adjunct without Levodopa: Rasagiline 1 mg once dailyAs adjunct to Levodopa: Rasagiline 0.5 mg once daily
What are the side effects of Ralect 0.5 mg?
Common side effects of Rasagiline include: dizziness, spinning sensation, joint pain, headache, heartburn, nausea, muscle pain etc.
Who should not take Ralect 0.5 mg?
Rasagiline is contraindicated for use with meperidine, tramadol, methadone, propoxyphene and MAO inhibitors (MAOIs), including other selective MAO-B inhibitors, because of risk of serotonin syndrome.
What precautions should be taken with Ralect 0.5 mg?
Exacerbation of hypertension may occur during treatment with Rasagiline. Medication adjustment may be necessary if elevation of blood pressure is sustained. Dose should not exceed 0.5 mg once daily for patients with mild hepatic impairment or taking concomitant Ciprofloxacin or other CYP1A2 inhibitors.
Is Ralect 0.5 mg safe during pregnancy and breastfeeding?
Pregnancy Category C. Rasagiline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. So, caution should be exercised when administered to a nursing woman.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.