Santinal MR200 mg
Capsule
Dipyridamole
Unimed Unihealth MFG. Ltd.
Product Code : 15406
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Medicine overview
Indications of Santinal MR 200 mg
Santinal MR 200 mg is indicated in Prophylaxis of thromboembolism following cardiac valve replacement, Secondary prophylaxis of stroke or transient ischaemic attack
Theropeutic Class
Anti-platelet drugs
Pharmacology
Santinal MR 200 mg causes an accumulation of adenosine, adenine nucleotides and cAMP by inhibiting the activity of adenosine deaminase and phosphodiesterase thus inhibiting platelet aggregation and may cause vasodilation.
Dosage of Santinal MR 200 mg
Prophylaxis of thromboembolism following cardiac valve replacement:
Adult: 300-600 mg/day in divided doses with an oral anticoagulant.
Child: 5 mg/kg/day in divided doses.
Secondary prophylaxis of stroke or transient ischaemic attack:
Adult: As modified-release preparation: 200 mg bid, with or without aspirin.
Administration of Santinal MR 200 mg
Should be taken on an empty stomach. Take 1 hr before meals. May be taken with meals to reduce GI discomfort.
Interaction of Santinal MR 200 mg
Aminophylline may reverse vasodilatation effect. Useful combination with aspirin in prevention of thromboembolism. Efficacy reduced by concurrent admin of antacids. Concurrent use may increase the cardiotoxic effects of adenosine.
Contraindications
Hypersensitivity. Peptic ulcer.
Side Effects of Santinal MR 200 mg
GI disturbances, headache, dizziness, faintness, facial flushing, skin rash, liver dysfunction, angina. Large doses may lower BP.
Pregnancy & Lactation
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Precautions & Warnings
In patients with rapidly worsening angina, subvalvular aortic stenosis, haemodynamic instability associated with recent MI or coagulation disorders esp when given IV during myocardial imaging. Hypotension, unstable angina, aortic stenosis. Pregnancy and lactation. Safety and efficacy are not established in childn < 12 yrs.
Overdose Effects of Santinal MR 200 mg
Symptoms: warm feeling, flushes, sweating, restlessness, weakness, dizziness, hypotension and tachycardia. Management: treatment is symptomatic. Empty stomach by gastric lavage. Haemodialysis unlikely to be useful.
Storage Conditions
Store below 25° C.
Drug Classes
Anti-platelet drugs
Mode Of Action
Santinal MR 200 mg causes an accumulation of adenosine, adenine nucleotides and cAMP by inhibiting the activity of adenosine deaminase and phosphodiesterase thus inhibiting platelet aggregation and may cause vasodilation.
Pregnancy
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.
