10% Off
A-Clox125 mg/5 m
ACME Laboratories Ltd.
৳40.47
Add to cart
Sinaclox125 mg/5 ml
Powder for Suspension
By
Best PriceTk /
1
Alternatives
Price
Medicine overview
Indications of Sinaclox 125 mg/5 ml
AbscessesCarbunclesFurunculosisCellulitisInfected woundsInfected burnsOtitis media and externaProtection of skin graft and Skin infections like ulcereczemaacneetc. Respiratory tract infections : PneumoniaLung abscessEmpyemaSinusitisPharyngitis and Tonsillitis. Other infections caused by sensitive organisms : OsteomyelitisEnteritisEndocarditisUrinary tract infectionMeningitis and Septicaemia.
Theropeutic Class
Penicillinase-resistant penicillins
Pharmacology
Sinaclox 125 mg/5 ml inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls.
Absorption
Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Dosage & Administration of Sinaclox 125 mg/5 ml
Upper Respiratory Tract Infection (Adult)
Dosage:Usual Dose: 250 mg orally every 6 hours for 7 to 14 days, depending on the nature and severity of the infection
Maximum dose
Dosage:4 g/day
Upper Respiratory Tract Infection (Pediatric)
Dosage:Usual Dose: The safety and efficacy of Sinaclox 125 mg/5 ml in children < 1 year have not been established
Notes:≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours
Maximum dose
Dosage:4 g/day
Pneumonia (Adult)
Dosage:Usual Dose: 500 mg orally every 6 hours for up to 21 days, depending on the nature and severity of the infection
Maximum dose
Dosage:4 g/day
Pneumonia (Pediatric)
Dosage:Usual Dose: The safety and efficacy of Sinaclox 125 mg/5 ml in children < 1 year have not been established
Notes:≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours
Maximum dose
Dosage:4 g/day
Skin and Structure Infection (Adult)
Dosage:Usual Dose: 500 mg orally every 6 hours for 7 days, or until 3 days after acute inflammation resolves, depending on the nature and severity of the infection
Maximum dose
Dosage:4 g/day
Skin and Structure Infection (Pediatric)
Dosage:Usual Dose: The safety and efficacy of Sinaclox 125 mg/5 ml in children < 1 year have not been established
Notes:≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours
Maximum dose
Dosage:4 g/day
Cystitis
Dosage:Usual Adult Dose: 250 mg orally every 6 hours for 3 to 7 days, depending on the nature and severity of the infection
Notes:Sinaclox 125 mg/5 ml is rarely indicated for the treatment of cystitis
Maximum dose
Dosage:4 g/day
| Condition | Dosage | Notes |
|---|---|---|
| Upper Respiratory Tract Infection (Adult) | Usual Dose: 250 mg orally every 6 hours for 7 to 14 days, depending on the nature and severity of the infection | |
| Maximum dose | 4 g/day | |
| Upper Respiratory Tract Infection (Pediatric) | Usual Dose: The safety and efficacy of Sinaclox 125 mg/5 ml in children < 1 year have not been established | ≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours |
| Maximum dose | 4 g/day | |
| Pneumonia (Adult) | Usual Dose: 500 mg orally every 6 hours for up to 21 days, depending on the nature and severity of the infection | |
| Maximum dose | 4 g/day | |
| Pneumonia (Pediatric) | Usual Dose: The safety and efficacy of Sinaclox 125 mg/5 ml in children < 1 year have not been established | ≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours |
| Maximum dose | 4 g/day | |
| Skin and Structure Infection (Adult) | Usual Dose: 500 mg orally every 6 hours for 7 days, or until 3 days after acute inflammation resolves, depending on the nature and severity of the infection | |
| Maximum dose | 4 g/day | |
| Skin and Structure Infection (Pediatric) | Usual Dose: The safety and efficacy of Sinaclox 125 mg/5 ml in children < 1 year have not been established | ≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours |
| Maximum dose | 4 g/day | |
| Cystitis | Usual Adult Dose: 250 mg orally every 6 hours for 3 to 7 days, depending on the nature and severity of the infection | Sinaclox 125 mg/5 ml is rarely indicated for the treatment of cystitis |
| Maximum dose | 4 g/day |
Interaction of Sinaclox 125 mg/5 ml
May diminish the effect of BCG and typhoid vaccine. May increase risk of methotrexate toxicity. May diminish the therapeutic effect of Na picosulfate. May decrease serum concentrations of mycophenolate. May prolong bleeding time with anticoagulants. Increased serum concentrations with probenecid. Tetracycline may antagonise the bactericidal effect of Sinaclox 125 mg/5 ml.
Contraindications
Sinaclox 125 mg/5 ml should not be given to patients known to be hypersensitive to penicillin.
Side Effects of Sinaclox 125 mg/5 ml
Common side effects are skin rash, transient diarrhoea, nausea, heartburn, pruritus and disturbance of blood electrolyte. Rarely anaphylactic shock.
Pregnancy & Lactation
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Precautions & Warnings
Sinaclox 125 mg/5 ml should be given with caution to patients with known history of allergy.
Storage Conditions
Dry powder: Store below 25° C. Reconstituted solution: Store between 2-8° C (stable for 4 days); 23° C (stable for 24 hr).
Frequently Asked Questions
What is Sinaclox 125 mg/5 ml used for?
Cloxacillin is indicated for the treatment of infections caused by Grampositive organisms including infections caused by β-lactamase producing Staphylococci such as : Skin and soft tissue infections : Boils, Abscesses, Carbuncles, Furunculosis, Cellulitis, Infected wounds, Infected burns, Otitis media and externa, Protection of skin graft and Skin infections like ulcer, eczema, acne, etc. Respirat…
What is the dosage of Sinaclox 125 mg/5 ml?
Upper Respiratory Tract Infection (Adult): Usual Dose: 250 mg orally every 6 hours for 7 to 14 days, depending on the nature and severity of the infection. Maximum dose: 4 g/day. Upper Respiratory Tract Infection (Pediatric): Usual Dose: The safety and efficacy of cloxacillin in children < 1 year have not been established. ≥ 1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours. Max…
What are the side effects of Sinaclox 125 mg/5 ml?
Common side effects are skin rash, transient diarrhoea, nausea, heartburn, pruritus and disturbance of blood electrolyte. Rarely anaphylactic shock.
Who should not take Sinaclox 125 mg/5 ml?
Cloxacillin should not be given to patients known to be hypersensitive to penicillin.
What precautions should be taken with Sinaclox 125 mg/5 ml?
Cloxacillin should be given with caution to patients with known history of allergy.
Is Sinaclox 125 mg/5 ml safe during pregnancy and breastfeeding?
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.