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Stilamin

Stilamin3 mg/ampoule

IV Injection

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Medicine overview

Indications of Stilamin 3 mg/ampoule

or accompanying acute erosive or haemorrhagic gastritis. Adjuvant treatment of pancreaticor accompanying acute erosive or haemorrhagic gastritis. Adjuvant treatment of pancreaticbiliary and intestinal fistulae. Prophylaxis and treatment of postoperative complications following pancreatic surgery.

Theropeutic Class

Growth hormone antagonist

Pharmacology

Stilamin 3 mg/ampoule is a synthetic cyclic 14 amino-acid peptide, which is identical in structure and action to natural Stilamin 3 mg/ampoule.

Absorption

By intravenous infusion in humans, Stilamin 3 mg/ampoule causes inhibition of growth hormone, thyroid stimulating hormone, insulin and glucagon secretion as well as inhibition of gastric acid secretion. It also affects the absorption, motility, splanchnic blood flow and trophic functions of the gastro-intestinal tract. Physiologically, Stilamin 3 mg/ampoule is found mainly in the gastro-intestinal tract and in the hypothalamus. Stilamin 3 mg/ampoule inhibits the release of gastrin, gastric acid, and pepsin which supports its indication in the treatment of upper gastro-intestinal haemorrhage.

Distribution

Stilamin 3 mg/ampoule reduces both pancreatic endocrine and exocrine secretion which makes it effective in the prophylaxis and treatment of postoperative complications of pancreatic surgery.

Metabolism

The positive effect of Stilamin 3 mg/ampoule in the management of diabetic ketoacidosis can be ascribed to its suppression activity of glucagon secretion.

Dosage & Administration of Stilamin 3 mg/ampoule

Stilamin 3 mg/ampoule is given intravenously, by slow bolus injection (3 to 5 minutes) of 250 µg or by continuous infusion at a rate of 250 µg/hour (equivalent of approximately 3.5 µg/kg body weight/hour). The lyophilised powder should be reconstituted with the physiological sodium chloride solution immediately prior to use. For continuous infusion one 3 mg of Stilamin 3 mg/ampoule ampoule should be used to prepare a 12 hours infusion. The solution may be either saline or 5 % dextrose and should be adjusted to guarantee an outflow of 250 µg Stilamin 3 mg/ampoule/hour. The use of a perfusion syringe is recommended.Treatment of severe acute bleeding from the upper gastro-intestinal tract, including from oesophageal varices: It is recommended to start by a slow intravenous injection of 250 µg of Stilamin 3 mg/ampoule as loading dose, then immediately followed by an intravenous infusion at a rate of 250 µg/h. In case of interruption of more than 3 to 5 minutes between two infusions, an additional slow intravenous injection of 250 µg is recommended to ensure a continuous treatment. Once the haemorrhage has stopped (usually in less than 12 to 24 hours), treatment should be continued for 48-72 hours in order to avoid rebleeding. Treatment up to 120 hours has been routinely performed in this indication.Adjuvant treatment in pancreatic, biliary and intestinal fistulae: A continuous infusion of Stilamin 3 mg/ampoule at a rate of 250 µg/h is recommended until closure of the fistulae (2-20 days). This infusion should be performed in addition to total parenteral nutrition. Once the fistula has been closed, treatment should be continued for 1 to 3 days and stopped progressively in order to avoid rebound effect. Prophylactic treatment of postoperative complications following pancreatic surgery: Stilamin 3 mg/ampoule is administered at the beginning of the surgical intervention at a rate of 250 µg/h and treatment is continued for 5 days.

Dosage of Stilamin 3 mg/ampoule

Stilamin 3 mg/ampoule is given intravenously, by slow bolus injection (3 to 5 minutes) of 250 µg or by continuous infusion at a rate of 250 µg/hour (equivalent of approximately 3.5 µg/kg body weight/hour). The lyophilised powder should be reconstituted with the physiological sodium chloride solution immediately prior to use. For continuous infusion one 3 mg of Stilamin 3 mg/ampoule ampoule should be used to prepare a 12 hours infusion. The solution may be either saline or 5 % dextrose and should be adjusted to guarantee an outflow of 250 µg Stilamin 3 mg/ampoule/hour. The use of a perfusion syringe is recommended.Treatment of severe acute bleeding from the upper gastro-intestinal tract, including from oesophageal varices: It is recommended to start by a slow intravenous injection of 250 µg of Stilamin 3 mg/ampoule as loading dose, then immediately followed by an intravenous infusion at a rate of 250 µg/h. In case of interruption of more than 3 to 5 minutes between two infusions, an additional slow intravenous injection of 250 µg is recommended to ensure a continuous treatment. Once the haemorrhage has stopped (usually in less than 12 to 24 hours), treatment should be continued for 48-72 hours in order to avoid rebleeding. Treatment up to 120 hours has been routinely performed in this indication.Adjuvant treatment in pancreatic, biliary and intestinal fistulae: A continuous infusion of Stilamin 3 mg/ampoule at a rate of 250 µg/h is recommended until closure of the fistulae (2-20 days). This infusion should be performed in addition to total parenteral nutrition. Once the fistula has been closed, treatment should be continued for 1 to 3 days and stopped progressively in order to avoid rebound effect. Prophylactic treatment of postoperative complications following pancreatic surgery: Stilamin 3 mg/ampoule is administered at the beginning of the surgical intervention at a rate of 250 µg/h and treatment is continued for 5 days.

Interaction of Stilamin 3 mg/ampoule

Since Stilamin 3 mg/ampoule lengthens the time of hexobarbital-induced sleep and potentiates the action of pentetrazol, Stilamin 3 mg/ampoule should not be administered concomitantly with these drugs or with drugs exerting the same effects.

Contraindications

Stilamin 3 mg/ampoule is contra-indicated: During pregnancy and the immediate post-partum period (puerperium) as well as during lactation. There is no evidence of the drug’s safety in human pregnancy nor is there evidence from animal work that it is free from hazard. In states of proven hypersensitivity to Stilamin 3 mg/ampoule.

Side Effects of Stilamin 3 mg/ampoule

Nausea, vertigo, and flushing have been reported rarely. Nausea and vomiting have been reported when the infusion rate is greater than 50 µg/min.

Pregnancy & Lactation

Avoid in pregnancy unless there is no safer alternative.

Precautions & Warnings

Due to its inhibitory effect on the secretion of insulin and glucagon, the administration of Stilamin 3 mg/ampoule can, at the onset of treatment, lead to a transient fall in blood glucose level. Caution is, therefore, called for in insulin-dependent diabetic patients in whom blood glucose should be measured every 3-4 hours. Simultaneous administration of insulin-requiring sugars should, if possible, be avoided. If necessary, insulin should be administered.

Storage Conditions

Storage condition and expiry date are indicated on the box. Solutions of Stilamin 3 mg/ampoule in physiological sodium chloride are stable for 24 hours.

Drug Classes

Growth hormone antagonist

Mode Of Action

Stilamin 3 mg/ampoule is a synthetic cyclic 14 amino-acid peptide, which is identical in structure and action to natural Stilamin 3 mg/ampoule. By intravenous infusion in humans, Stilamin 3 mg/ampoule causes inhibition of growth hormone, thyroid stimulating hormone, insulin and glucagon secretion as well as inhibition of gastric acid secretion. It also affects the absorption, motility, splanchnic blood flow and trophic functions of the gastro-intestinal tract. Physiologically, Stilamin 3 mg/ampoule is found mainly in the gastro-intestinal tract and in the hypothalamus.Stilamin 3 mg/ampoule inhibits the release of gastrin, gastric acid, and pepsin which supports its indication in the treatment of upper gastro-intestinal haemorrhage. Furthermore, Stilamin 3 mg/ampoule is capable of reducing remarkably splanchnic blood flow without causing significant variations in the systemic arterial pressure, which proves to be valuable for the management of oesophageal variceal haemorrhage. Stilamin 3 mg/ampoule reduces both pancreatic endocrine and exocrine secretion which makes it effective in the prophylaxis and treatment of postoperative complications of pancreatic surgery. The positive effect of Stilamin 3 mg/ampoule in the management of diabetic ketoacidosis can be ascribed to its suppression activity of glucagon secretion.

Pregnancy

Avoid in pregnancy unless there is no safer alternative.

Frequently Asked Questions

What is Stilamin 3 mg/ampoule used for?

Somatostatin is indicated for: Severe acute haemorrhage from oesophageal varices. Severe acute haemorrhage from gastric or duodenal ulcers, or accompanying acute erosive or haemorrhagic gastritis. Adjuvant treatment of pancreatic, biliary and intestinal fistulae. ... Read moreSomatostatin is indicated for: Severe acute haemorrhage from oesophageal varices. Severe acute haemorrhage from gastric or …

What is the dosage of Stilamin 3 mg/ampoule?

Somatostatin is given intravenously, by slow bolus injection (3 to 5 minutes) of 250 µg or by continuous infusion at a rate of 250 µg/hour (equivalent of approximately 3.5 µg/kg body weight/hour). The lyophilised powder should be reconstituted with the physiological sodium chloride solution immediately prior to use. For continuous infusion one 3 mg of Somatostatin ampoule should be used to prepare…

What are the side effects of Stilamin 3 mg/ampoule?

Nausea, vertigo, and flushing have been reported rarely. Nausea and vomiting have been reported when the infusion rate is greater than 50 µg/min.

Who should not take Stilamin 3 mg/ampoule?

Somatostatin is contra-indicated: During pregnancy and the immediate post-partum period (puerperium) as well as during lactation. There is no evidence of the drug’s safety in human pregnancy nor is there evidence from animal work that it is free from hazard. In states of proven hypersensitivity to somatostatin.

What precautions should be taken with Stilamin 3 mg/ampoule?

Due to its inhibitory effect on the secretion of insulin and glucagon, the administration of Somatostatin can, at the onset of treatment, lead to a transient fall in blood glucose level. Caution is, therefore, called for in insulin-dependent diabetic patients in whom blood glucose should be measured every 3-4 hours. Simultaneous administration of insulin-requiring sugars should, if possible, be av…

Is Stilamin 3 mg/ampoule safe during pregnancy and breastfeeding?

Avoid in pregnancy unless there is no safer alternative.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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