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D-boost40000 IU
C2C Pharma
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Sunrise-D40000 IU
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Medicine overview
Indications of Sunrise-D 40000 IU
Sunrise-D 40000 IU is an essential fat-soluble vitamin that plays a critical role in calcium and phosphate metabolismbone mineralizationleading to fatiguebone painosteomalaciaand osteoporosis . It is also essential for calcium absorptionimmune supportand maternal-fetal health during pregnancy and lactationmaking it a vital nutrient for overall skeletal and systemic health.
Pharmacology
Sunrise-D 40000 IU is a fat-soluble vitamin that undergoes sequential metabolic activation in the body to produce its biologically active form, which plays a central role in calcium-phosphate homeostasis, bone metabolism, and cellular regulation.
Absorption
Absorption and Distribution Vitamin D3 is absorbed in the small intestine along with dietary fats. Metabolism (Activation Pathway) Vitamin D3 undergoes two key hydroxylation steps for activation: Liver Conversion: Vitamin D3 is metabolized in the liver to 25-hydroxyvitamin D [25(OH)D] (Calcidiol) This is the major circulating storage form and clinical marker of Vitamin D status Kidney Activation: Calcidiol is further hydroxylated in the kidneys to form 1,25-dihydroxyvitamin D [1,25(OH)₂D] (Calcitriol) Calcitriol is the biologically active form responsible for most physiological effects Mechanism of Action Calcitriol binds to Vitamin D Receptors (VDRs) , which are widely distributed in various tissues, including: Intestine Bone Kidney Immune cells Activation of VDR leads to regulation of gene expression involved in: Calcium and phosphate absorption Bone mineralization and remodeling Cellular differentiation and immune modulation Physiological Effects Enhances intestinal absorption of calcium and phosphate Maintains serum calcium balance necessary for bone strength Supports bone formation, growth, and remodeling Contributes to muscle function and neuromuscular stability Plays a role in immune system regulation Elimination Vitamin D3 and its metabolites are eliminated slowly through: Feces Urine Due to its fat solubility and tissue storage, clearance is gradual, contributing to its prolonged activity in the body.
Distribution
Absorption and Distribution Vitamin D3 is absorbed in the small intestine along with dietary fats. Being fat-soluble , it is distributed and stored in body tissues, particularly: Adipose (fat) tissue Muscle tissue It has a long biological half-life of approximately 50 days , allowing sustained physiological effects. Metabolism (Activation Pathway) Vitamin D3 undergoes two key hydroxylation steps for activation: Liver Conversion: Vitamin D3 is metabolized in the liver to 25-hydroxyvitamin D [25(OH)D] (Calcidiol) This is the major circulating storage form and clinical marker of Vitamin D status Kidney Activation: Calcidiol is further hydroxylated in the kidneys to form 1,25-dihydroxyvitamin D [1,25(OH)₂D] (Calcitriol) Calcitriol is the biologically active form responsible for most physiological effects Mechanism of Action Calcitriol binds to Vitamin D Receptors (VDRs) , which are widely distributed in various tissues, including: Intestine Bone Kidney Immune cells Activation of VDR leads to regulation of gene expression involved in: Calcium and phosphate absorption Bone mineralization and remodeling Cellular differentiation and immune modulation Physiological Effects Enhances intestinal absorption of calcium and phosphate Maintains serum calcium balance necessary for bone strength Supports bone formation, growth, and remodeling Contributes to muscle function and neuromuscular stability Plays a role in immune system regulation Elimination Vitamin D3 and its metabolites are eliminated slowly through: Feces Urine Due to its fat solubility and tissue storage, clearance is gradual, contributing to its prolonged activity in the body.
Metabolism
Being fat-soluble , it is distributed and stored in body tissues, particularly: Adipose (fat) tissue Muscle tissue It has a long biological half-life of approximately 50 days , allowing sustained physiological effects. Metabolism (Activation Pathway) Vitamin D3 undergoes two key hydroxylation steps for activation: Liver Conversion: Vitamin D3 is metabolized in the liver to 25-hydroxyvitamin D [25(OH)D] (Calcidiol) This is the major circulating storage form and clinical marker of Vitamin D status Kidney Activation: Calcidiol is further hydroxylated in the kidneys to form 1,25-dihydroxyvitamin D [1,25(OH)₂D] (Calcitriol) Calcitriol is the biologically active form responsible for most physiological effects Mechanism of Action Calcitriol binds to Vitamin D Receptors (VDRs) , which are widely distributed in various tissues, including: Intestine Bone Kidney Immune cells Activation of VDR leads to regulation of gene expression involved in: Calcium and phosphate absorption Bone mineralization and remodeling Cellular differentiation and immune modulation Physiological Effects Enhances intestinal absorption of calcium and phosphate Maintains serum calcium balance necessary for bone strength Supports bone formation, growth, and remodeling Contributes to muscle function and neuromuscular stability Plays a role in immune system regulation Elimination Vitamin D3 and its metabolites are eliminated slowly through: Feces Urine Due to its fat solubility and tissue storage, clearance is gradual, contributing to its prolonged activity in the body.
Excretion
Metabolism (Activation Pathway) Vitamin D3 undergoes two key hydroxylation steps for activation: Liver Conversion: Vitamin D3 is metabolized in the liver to 25-hydroxyvitamin D [25(OH)D] (Calcidiol) This is the major circulating storage form and clinical marker of Vitamin D status Kidney Activation: Calcidiol is further hydroxylated in the kidneys to form 1,25-dihydroxyvitamin D [1,25(OH)₂D] (Calcitriol) Calcitriol is the biologically active form responsible for most physiological effects Mechanism of Action Calcitriol binds to Vitamin D Receptors (VDRs) , which are widely distributed in various tissues, including: Intestine Bone Kidney Immune cells Activation of VDR leads to regulation of gene expression involved in: Calcium and phosphate absorption Bone mineralization and remodeling Cellular differentiation and immune modulation Physiological Effects Enhances intestinal absorption of calcium and phosphate Maintains serum calcium balance necessary for bone strength Supports bone formation, growth, and remodeling Contributes to muscle function and neuromuscular stability Plays a role in immune system regulation Elimination Vitamin D3 and its metabolites are eliminated slowly through: Feces Urine Due to its fat solubility and tissue storage, clearance is gradual, contributing to its prolonged activity in the body.
Dosage & Administration of Sunrise-D 40000 IU
The dosage of Sunrise-D 40000 IU varies depending on age, clinical condition, formulation, and therapeutic goal (treatment or prevention of deficiency). It should always be used under medical supervision with periodic monitoring of serum Vitamin D levels when required.
Adult Dosage
Treatment of Vitamin D3 Deficiency
- 40,000 IU once weekly for 7 weeks
- After correction, maintenance dose:
- 1,400–2,000 IU daily
- Serum 25-hydroxyvitamin D levels should be checked 3–4 months after starting maintenance therapy to ensure target levels are achieved.
Prevention of Vitamin D3 Deficiency
- 20,000 IU every 4 weeks
- Higher doses may be required in high-risk individuals (e.g., limited sun exposure, malabsorption, elderly)
Adjunct in Osteoporosis Therapy
- 20,000 IU once monthly
- Used alongside calcium and other anti-osteoporotic treatments
Pediatric & Adolescent Dosage (12–18 years)
Treatment of Deficiency
- 20,000 IU once every 2 weeks for 6 weeks
Prevention of Deficiency
- 20,000 IU once every 6 weeks
Oral Solid Forms
Film-Coated Tablets
- 1,000 IU daily (1–2 tablets daily)
- Take with food or within 1 hour after meals
Chewable / Orodispersible Tablets
- 1,000–2,000 IU daily
- Take with food or within 1 hour after meals
- Tablets should be chewed or allowed to dissolve in the mouth before swallowing
Oral Solution
Infants (Up to 1 year)
- 400 IU once daily
Children (1–18 years)
- 600 IU once daily
Injectable Form (Depot Preparation)
Treatment Indications
- Rickets: 1 ampoule every 2 weeks for 1 month, then every 4 months
- Osteoporosis: 1 ampoule every 2 weeks for 3 months
- Osteomalacia: 1 ampoule every 2 weeks for 3 months
- Hypocalcemic tetany: 1 ampoule every 4 months (may increase to 2 ampoules if needed)
- Menopausal deficiency: 1 ampoule every 6 months
- Vitamin D deficiency: 1 ampoule, repeat after 1–6 months if required
Prevention Indications
- Pregnancy: ½ ampoule in the 6th or 7th month
- Lactation: ½ ampoule every 6 months
- Children (up to 5 years): 1 ampoule every 6 months
- Adolescents: 1 ampoule every 6 months
- Elderly: ½ ampoule every 3 months
Direction for Injectable Form
For Oral Use
- Break the narrow top of the ampoule using the thumb
- Pour solution into a spoon
- Mix with water or milk before swallowing
For Intramuscular (IM) Use
- Break the ampoule top
- Withdraw solution
- Administer as deep IM injection under medical supervision
Interaction of Sunrise-D 40000 IU
Sunrise-D 40000 IU may interact with several medications that affect its metabolism, absorption, or physiological actions. These interactions may reduce its effectiveness or increase the risk of adverse effects such as altered calcium balance. Careful monitoring and dose adjustment may be required when used concomitantly with certain drugs.
Anticonvulsants (Phenytoin, Barbiturates)
These drugs can increase hepatic metabolism of Vitamin D3 , reducing its therapeutic effect.
May lead to decreased serum Vitamin D levels and reduced calcium absorption.
Glucocorticoids
Long-term corticosteroid therapy can reduce the effect of Vitamin D3 by:
Impairing calcium absorption
Increasing calcium excretion
May contribute to bone loss and reduced Vitamin D activity.
Cardiac Glycosides (e.g., Digoxin)
Concomitant use with Vitamin D3 (especially when combined with calcium) may:
Enhance the risk of arrhythmias due to increased serum calcium
Strict medical supervision
Regular ECG monitoring
Monitoring of serum calcium levels
Bile Acid Sequestrants (e.g., Cholestyramine)
May reduce gastrointestinal absorption of Vitamin D3 by binding fat-soluble vitamins in the intestine.
Can lead to reduced therapeutic efficacy.
Laxatives (e.g., Liquid Paraffin/Oil-based laxatives)
May decrease absorption of fat-soluble vitamins, including Vitamin D3.
Prolonged use may contribute to deficiency.
Antineoplastic and Antifungal Agents
Actinomycin and imidazole antifungals may interfere with Vitamin D activation by:
Inhibiting renal enzyme 25-hydroxyvitamin D-1-hydroxylase
Reducing formation of active calcitriol (1,25-dihydroxyvitamin D)
Clinical Considerations
Monitor serum calcium and Vitamin D levels in patients on long-term interacting medications
Adjust Vitamin D dosage as required based on response
Use caution in patients receiving multiple interacting drugs simultaneously
Contraindications
Sunrise-D 40000 IU should not be used in certain medical conditions where it may worsen calcium imbalance or pose a risk of toxicity. Careful patient evaluation is essential before initiating therapy.
Hypercalcaemia and Related Disorders
- Contraindicated in all conditions associated with Hypercalcaemia
- Use may further increase serum calcium levels, leading to complications such as:
- Kidney dysfunction
- Cardiac arrhythmias
- Neurological symptoms
Vitamin D Hypersensitivity
- Contraindicated in patients with:
- Known hypersensitivity to Vitamin D3 (cholecalciferol)
- Hypersensitivity to any structurally related compounds or formulations
- Allergy to any excipients present in the dosage form
Vitamin D Toxicity
- Contraindicated in cases of existing Vitamin D Toxicity
- Additional administration may worsen toxicity symptoms such as:
- Severe hypercalcaemia
- Nausea, vomiting
- Soft tissue calcification
- Renal impairment
Clinical Precautions
Although not absolute contraindications, caution is required in the following situations:
- History of recurrent kidney stones or impaired calcium metabolism
- Severe renal impairment or chronic kidney disease
- Sarcoidosis or other granulomatous diseases (may increase endogenous Vitamin D activation)
- Patients receiving high doses of calcium or other Vitamin D–containing products
Side Effects of Sunrise-D 40000 IU
Sunrise-D 40000 IU is generally considered a safe and well-tolerated nutritional supplement when used at recommended doses. However, adverse effects may occur, particularly in cases of high-dose or prolonged use, individual sensitivity, or abnormal calcium metabolism.
General Safety Profile
- Vitamin D3 is usually well tolerated when taken within prescribed doses
- Most users do not experience significant adverse effects under normal supplementation
Metabolic and Calcium-Related Effects
- Hypercalcaemia (calcium intoxication)
- May occur with excessive or prolonged dosing
- Can lead to symptoms such as fatigue, weakness, or altered consciousness in severe cases
- Hypocalcaemia syndrome (rare and context-dependent)
- May occur depending on underlying metabolic imbalance or treatment context
Gastrointestinal Symptoms
Occasionally reported, especially with higher doses:
- Nausea
- Vomiting
- Abdominal pain or stomach discomfort
- Constipation
- Loss of appetite (anorexia)
Neurological Symptoms
- Headache
- General weakness or fatigue (rare)
Dose-Related Risk
- Side effects are more likely with excessive or long-term high-dose use
- Toxicity is primarily related to elevated calcium levels (hypercalcaemia) rather than direct vitamin toxicity
- Risk increases when combined with additional calcium or Vitamin D supplements
Pregnancy & Lactation
Sunrise-D 40000 IU is an essential nutrient during pregnancy and breastfeeding, playing a key role in maternal bone health, fetal skeletal development, and calcium regulation. However, dosing should be carefully individualized based on clinical need and medical supervision.
Use During Pregnancy
- Clinical studies have shown that Vitamin D3 is safe in doses up to 4,000 IU daily during pregnancy.
- The recommended daily intake is approximately 400 IU, but requirements may vary depending on individual Vitamin D status.
Clinical Considerations:
- Higher doses may be required in pregnant women with Vitamin D Deficiency
- Supplementation should be individualized based on serum 25-hydroxyvitamin D levels
- Treatment decisions should always be guided by a healthcare professional to ensure optimal maternal and fetal outcomes
Use During Lactation (Breastfeeding)
- Vitamin D3 and its metabolites are excreted into breast milk
- However, vitamin D toxicity in breastfed infants has not been observed when mothers take recommended doses
Important Considerations:
- If a breastfed infant is receiving additional Vitamin D supplementation, clinicians should:
- Evaluate the total Vitamin D intake from both mother and infant
- Avoid excessive cumulative dosing
- Maternal supplementation is generally considered beneficial for maintaining adequate Vitamin D levels in both mother and infant
Clinical Guidance
- Dose requirements may vary based on:
- Maternal Vitamin D status
- Dietary intake and sunlight exposure
- Presence of deficiency or high-risk conditions
- Regular monitoring may be recommended in high-risk pregnancies
Precautions & Warnings
The use of Sunrise-D 40000 IU requires careful medical supervision in certain patient groups due to its effects on calcium metabolism and potential risk of hypercalcaemia.
Monitoring Requirements
- Plasma calcium levels should be regularly monitored in:
- Patients receiving high-dose Vitamin D3 therapy
- Individuals with renal impairment
- Pregnant and lactating women receiving supplementation
Regular monitoring helps prevent complications such as Hypercalcaemia.
Drug Interaction Precautions
Cardiac Glycosides (e.g., Digoxin)
- Patients using digoxin should consult a healthcare professional before taking Vitamin D3
- Increased calcium levels may enhance the risk of cardiac arrhythmias
Thiazide Diuretics
- Concomitant use may reduce urinary calcium excretion
- This can increase the risk of hypercalcaemia, requiring clinical monitoring
Medical Condition–Related Warnings
Patients with the following conditions should use Vitamin D3 only under strict medical supervision:
- Liver Disease
- Kidney Disease
- Hyperthyroidism
- Lymphoma
- Tuberculosis
- Granulomatous Disease
These conditions may increase sensitivity to Vitamin D3 or alter its metabolism, increasing the risk of toxicity.
Clinical Caution Points
- Avoid unsupervised high-dose supplementation
- Consider baseline and periodic monitoring of calcium and vitamin D status in high-risk individuals
- Use with caution in patients on multiple medications affecting calcium balance
- Adjust dosage based on clinical response and laboratory findings
Overdose Effects of Sunrise-D 40000 IU
Overdose of Sunrise-D 40000 IU may lead to serious metabolic disturbances, primarily due to excessive calcium accumulation in the blood and tissues.
Primary Toxic Effect
The most significant consequence of acute or chronic overdose is Hypercalcaemia, resulting from Vitamin D toxicity.
Acute Overdose Symptoms
Excessive intake of Vitamin D3 may cause the following symptoms:
- Nausea
- Vomiting
- Loss of appetite (anorexia)
- Weakness and fatigue
- Excessive thirst (polydipsia)
- Frequent urination (polyuria)
- Constipation
- Mental apathy or reduced alertness
These symptoms are mainly associated with elevated serum calcium levels.
Chronic Overdose Effects
Long-term excessive intake may result in more severe complications, including:
- Persistent hypercalcaemia
- Calcification of blood vessels (vascular calcification)
- Deposition of calcium in soft tissues and organs (e.g., kidneys, heart)
- Potential impairment of renal and cardiovascular function
Management of Overdose
In suspected Vitamin D toxicity, immediate medical intervention is required:
- Discontinue all sources of Vitamin D intake immediately
- Initiate adequate hydration (rehydration therapy)
- Monitor serum calcium and renal function
- Additional supportive treatment may be required depending on severity
Storage Conditions
Store in a cool (below 25°C) and dry place protected from light. Keep away from the reach of children.
Frequently Asked Questions
What is Sunrise-D 40000 IU used for?
Cholecalciferol [Vitamin D3] is an essential fat-soluble vitamin that plays a critical role in calcium and phosphate metabolism, bone mineralization, and immune system regulation. It is indicated for the prevention and treatment of Vitamin D deficiency and related health conditions. Primary Indications Vitamin D Deficiency Used in individuals with inadequate sunlight exposure or insufficient dieta…
What is the dosage of Sunrise-D 40000 IU?
The dosage of Cholecalciferol [Vitamin D3] varies depending on age, clinical condition, formulation, and therapeutic goal (treatment or prevention of deficiency). It should always be used under medical supervision with periodic monitoring of serum Vitamin D levels when required. Adult Dosage Treatment of Vitamin D3 Deficiency 40,000 IU once weekly for 7 weeks After correction, maintenance dose: 1,…
What are the side effects of Sunrise-D 40000 IU?
Cholecalciferol [Vitamin D3] is generally considered a safe and well-tolerated nutritional supplement when used at recommended doses. However, adverse effects may occur, particularly in cases of high-dose or prolonged use, individual sensitivity, or abnormal calcium metabolism. General Safety Profile Vitamin D3 is usually well tolerated when taken within prescribed doses Most users do not experien…
Who should not take Sunrise-D 40000 IU?
Cholecalciferol [Vitamin D3] should not be used in certain medical conditions where it may worsen calcium imbalance or pose a risk of toxicity. Careful patient evaluation is essential before initiating therapy. Hypercalcaemia and Related Disorders Contraindicated in all conditions associated with Hypercalcaemia Use may further increase serum calcium levels, leading to complications such as: Kidney…
What precautions should be taken with Sunrise-D 40000 IU?
The use of Cholecalciferol [Vitamin D3] requires careful medical supervision in certain patient groups due to its effects on calcium metabolism and potential risk of hypercalcaemia. Monitoring Requirements Plasma calcium levels should be regularly monitored in: Patients receiving high-dose Vitamin D3 therapy Individuals with renal impairment Pregnant and lactating women receiving supplementation R…
Is Sunrise-D 40000 IU safe during pregnancy and breastfeeding?
Cholecalciferol [Vitamin D3] is an essential nutrient during pregnancy and breastfeeding, playing a key role in maternal bone health, fetal skeletal development, and calcium regulation. However, dosing should be carefully individualized based on clinical need and medical supervision. Use During Pregnancy Clinical studies have shown that Vitamin D3 is safe in doses up to 4,000 IU daily during pregn…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.