Syntar0.1%+0.3%

Syntar ophthalmic solution is an over-the-counter (OTC) artificial tear / ocular lubricant preparation, established for the following use:

• Symptomatic relief of dry eye: Temporary relief of burning, stinging, and irritation due to dryness of the eye (keratoconjunctivitis sicca) and for use as a protectant against further irritation.
• Ocular surface lubrication: Relief of minor eye irritation caused by exposure to wind, sun, or environmental dryness.
• Adjunct comfort with contact lenses: May be used as a lubricant to relieve dryness and discomfort associated with contact lens wear when the product is labeled as compatible with lenses.

This is an established, guideline-supported OTC indication (ophthalmic demulcent monograph); it is not intended to treat infections, allergies, or underlying ocular disease.

Each mL of Dextran + Hypromellose ophthalmic solution typically contains:

• Dextran 70 - 0.1% w/v
• Hypromellose (Hydroxypropyl Methylcellulose) - 0.3% w/v

Along with preservative(s) (e.g., benzalkonium chloride in multi-dose preparations, or preservative-free single-use formulations) and other inactive/buffering ingredients. Exact strengths and excipients may vary slightly by manufacturer; refer to the specific product label.

Syntar is a combination ophthalmic lubricant (artificial tear) preparation used for the symptomatic relief of dry and irritated eyes. Dextran is a high-molecular-weight polysaccharide that increases the viscosity of the tear film, while Hypromellose is a cellulose-derivative demulcent that coats and lubricates the ocular surface.

Together, these ingredients form a stable, protective film over the cornea and conjunctiva, helping to retain moisture, reduce friction during blinking, and relieve the discomfort associated with insufficient natural tear production. Syntar is available as an over-the-counter ophthalmic solution and does not require a prescription in most markets, including Bangladesh.

Syntar belongs to the therapeutic class of Ophthalmic Lubricants / Artificial Tear Preparations (Ocular Demulcents), used for the management of dry eye and ocular surface irritation.

Dextran + Hypromellose works through complementary physical (non-pharmacological) mechanisms rather than a receptor-based pharmacologic action:

• Dextran 70: A branched polysaccharide that increases the viscosity and adhesiveness of the tear film, prolonging its retention time on the ocular surface.
• Hypromellose: A hydrophilic cellulose derivative that acts as a demulcent, forming a smooth, lubricating film that coats the cornea and conjunctiva, protects against desiccation, and reduces mechanical irritation from blinking.

Together, the combination stabilizes the pre-corneal tear film, reduces tear evaporation, and provides symptomatic comfort. Systemic absorption after topical ophthalmic application is negligible.

Syntar is for topical ophthalmic (eye) use only and must not be injected or taken orally.

• Wash hands thoroughly before use.
• Avoid touching the dropper tip to the eye or any other surface.
• Remove contact lenses before instillation unless the product is labeled as safe for use with lenses.
• Replace the cap tightly after each use.
• If redness, irritation, or discomfort persists or worsens, discontinue use and consult a physician.

Syntar has minimal systemic absorption when used topically in the eye, so clinically significant systemic drug interactions are not expected.

• Other ophthalmic products: If using other eye drops or ointments concurrently, space administration at least 5-10 minutes apart to prevent one product from washing out another and to allow adequate absorption/contact time.
• Ophthalmic preparations containing preservatives: Frequent concurrent use of multiple preserved eye drops may increase the risk of local irritation; preservative-free formulations may be preferred in such cases.

Syntar is generally well tolerated. Reported side effects are mostly local and transient:

• Temporary blurred vision immediately after instillation
• Mild stinging, burning, or a foreign-body sensation on instillation
• Ocular discomfort, itching, or watering
• Rarely, hypersensitivity reactions such as eyelid redness, swelling, or itching

If irritation, eye pain, vision changes, or redness worsens or persists, discontinue use and seek medical advice.

Syntar is applied topically to the eye with minimal systemic absorption. While significant fetal or infant risk is not expected, as with any medication, it should be used during pregnancy and breastfeeding only if clearly needed, and a physician or pharmacist should be consulted before use to confirm appropriateness for the individual situation.

Observe the following precautions when using Syntar:

• For topical ophthalmic use only; do not inject or swallow.
• Remove contact lenses before instillation unless the product is specifically labeled as safe for use with contact lenses.
• Avoid touching the dropper tip to the eye, eyelid, fingers, or any surface to prevent contamination of the solution.
• Do not use if the solution changes color, becomes cloudy, or if the tamper-evident seal is broken.
• Discontinue use and consult a physician if eye pain, vision changes, or redness persists or worsens, or if symptoms do not improve within 72 hours.
• Discard the container per the labeled discard period after first opening (commonly within 4 weeks), even if solution remains.
• Keep out of reach of children.

Overdose with Syntar is unlikely to cause serious systemic toxicity because of its topical route and minimal systemic absorption. Excessive ocular application may cause transient watering, blurred vision, or local irritation, which typically resolves on its own.

If accidentally ingested in large amounts, or if a severe or unexpected reaction occurs, seek immediate medical attention or contact a poison control center rather than attempting home treatment.

Store at room temperature (below 30°C), away from light and moisture. Do not freeze. Keep the container tightly closed when not in use, and keep out of reach of children. Discard any unused solution after the manufacturer's recommended period following first opening.

Elderly: No special dose adjustment is required; Syntar is commonly used in elderly patients for age-related dry eye.

Renal/hepatic impairment: No dose adjustment is expected to be necessary given the negligible systemic absorption of Syntar after topical ophthalmic use.

Children: See Pediatric Use.

Contact lens wearers: Remove lenses before instillation unless the product is specifically labeled compatible with contact lens wear.

Syntar may be used as needed for symptomatic relief of dry eye and can be continued long-term for chronic dry eye under medical guidance. If symptoms persist or worsen after 72 hours of regular use, or if the condition appears to require more than temporary relief, a physician should be consulted to evaluate for an underlying cause.

Dextran + Hypromellose falls under the drug class of Ophthalmic Lubricants / Artificial Tear Substitutes (Ocular Demulcents), combining a viscosity-enhancing agent (dextran) with a cellulose-based demulcent (hypromellose).

Dextran + Hypromellose acts through physical, non-receptor-mediated mechanisms:

• Dextran 70 increases the viscosity of the tear film and enhances its adherence to the ocular surface, prolonging contact time.
• Hypromellose is a hydrophilic polymer that forms a smooth, lubricating, protective film over the cornea and conjunctiva, mimicking the mucin/aqueous layers of the natural tear film, reducing evaporation, and minimizing friction from blinking.

The combined effect is enhanced ocular surface lubrication, moisture retention, and symptomatic relief of dryness and irritation.

Syntar may be used in children for temporary relief of dry or irritated eyes in a manner similar to adults, as it is a topical lubricant with minimal systemic absorption. However, formal safety and efficacy data from controlled clinical trials in infants and young children are limited, so use in this age group should be under the guidance of a physician or pharmacist, particularly in infants.