medEasy MedEasy
Tericin

Tericin50 mg/vial

IV Infusion

By
MRP ৳ 15045.105% Off
Best PriceTk /
1
Section

Medicine overview

Indications of Tericin 50 mg/vial

Tericin 50 mg/vial is indicated for the following: Empirical therapy for presumed fungal infection in febrileCandida species and/or Cryptococcus species infections refractory to amphotericin B deoxycholateCandida species and/or Cryptococcus species infections refractory to amphotericin B deoxycholaterelapse rates were high following initial clearance of parasites

Theropeutic Class

Other Antifungal preparations

Pharmacology

Tericin 50 mg/vial is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus.

Absorption

The drug acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi.

Distribution

This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components.

Metabolism

Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles.

Excretion

Tericin 50 mg/vial, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

Dosage & Administration of Tericin 50 mg/vial

Systemic Fungal Infections- Test dose
Dosage:1 mg IV infused over 20-30 min Load: 0.25-0.5 mg/kg IV infused over 2-6 hour Maintenance: 0.25-1 mg/kg IV qDay OR up to 1.5 mg/kg IV every other day (may increase gradually by 0.25 mg-increments/day)

Dosage of Tericin 50 mg/vial

Systemic Fungal Infections- Test dose
Dosage:1 mg IV infused over 20-30 min Load: 0.25-0.5 mg/kg IV infused over 2-6 hour Maintenance: 0.25-1 mg/kg IV qDay OR up to 1.5 mg/kg IV every other day (may increase gradually by 0.25 mg-increments/day)

Interaction of Tericin 50 mg/vial

Increased toxicity with flucytosine. Drug induced renal toxicity enhanced in presence of other nephrotoxic medications. Antagonises effects of azole antifungals.

Contraindications

Tericin 50 mg/vial is contraindicated in those patients who have demonstrated or have known hypersensitivity to amphotericin B deoxycholate or any other constituents of the product unless, in the opinion of the treating physician, the benefit of therapy outweighs the risk.

Side Effects of Tericin 50 mg/vial

Common side effects are Fever, chills, convulsions, malaise; nausea, vomiting, diarrhoea, anorexia; tinnitus, vertigo, hearing loss; hypotension, hypertension, cardiac arrhythmias; peripheral neuropathy; phloebitis, pain at Inj site, disturbances in renal function and renal toxicity.

Pregnancy & Lactation

Pregnancy Category B. There have been no adequate and well-controlled studies of Tericin 50 mg/vial in pregnant women. It is not known whether Tericin 50 mg/vial is excreted in human milk.

Precautions & Warnings

As with any amphotericin B-containing product the drug should be administered by medically trained personnel. During the initial dosing period, patients should be under close clinical observation. amphotericin B has been shown to be significantly less toxic than amphotericin B deoxycholate; however, adverse events may still occur.

Storage Conditions

Unopened vials of lyophilized material are to be stored at temperatures up to 25°C. The reconstituted product concentrate may be stored for up to 24 hours at 2-8° C.

Reconstitution

Aseptically add 12 mL of Sterile Water for Injection, to each Tericin 50 mg/vial vial to yield a preparation containing 4 mg amphotericin B/mL. Immediately after the addition of water, shake the vial vigorously for 30 seconds to completely disperse the Tericin 50 mg/vial. This forms a yellow, translucent suspension. Visually inspect the vial for particulate matter and continue shaking until completely dispersed.

Drug Classes

Other Antifungal preparations

Mode Of Action

Tericin 50 mg/vial is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Tericin 50 mg/vial, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

Pregnancy

Pregnancy Category B. There have been no adequate and well-controlled studies of Tericin 50 mg/vial in pregnant women. It is not known whether Tericin 50 mg/vial is excreted in human milk.

Frequently Asked Questions

What is Tericin 50 mg/vial used for?

Amphotericin B is indicated for the following: Empirical therapy for presumed fungal infection in febrile, neutropenic patients. Treatment of Cryptococcal Meningitis in HIV infected patients Treatment of patients with Aspergillus species, Candida species and/or Cryptococcus species infections refractory to amphotericin B deoxycholate, or in patients where renal impairment or unacceptable toxicity …

What is the dosage of Tericin 50 mg/vial?

Systemic Fungal Infections- Test dose: 1 mg IV infused over 20-30 min Load: 0.25-0.5 mg/kg IV infused over 2-6 hour Maintenance: 0.25-1 mg/kg IV qDay OR up to 1.5 mg/kg IV every other day (may increase gradually by 0.25 mg-increments/day)

What are the side effects of Tericin 50 mg/vial?

Common side effects are Fever, chills, convulsions, malaise; nausea, vomiting, diarrhoea, anorexia; tinnitus, vertigo, hearing loss; hypotension, hypertension, cardiac arrhythmias; peripheral neuropathy; phloebitis, pain at Inj site, disturbances in renal function and renal toxicity.

Who should not take Tericin 50 mg/vial?

Amphotericin B is contraindicated in those patients who have demonstrated or have known hypersensitivity to amphotericin B deoxycholate or any other constituents of the product unless, in the opinion of the treating physician, the benefit of therapy outweighs the risk.

What precautions should be taken with Tericin 50 mg/vial?

As with any amphotericin B-containing product the drug should be administered by medically trained personnel. During the initial dosing period, patients should be under close clinical observation. amphotericin B has been shown to be significantly less toxic than amphotericin B deoxycholate; however, adverse events may still occur.

Is Tericin 50 mg/vial safe during pregnancy and breastfeeding?

Pregnancy Category B. There have been no adequate and well-controlled studies of Amphotericin B in pregnant women. It is not known whether Amphotericin B is excreted in human milk.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

Home