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Retabac1%
Square Pharmaceuticals PLC.
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Topibac1%
Ointment
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Medicine overview
Indications of Topibac 1%
Topibac 1% is indicated for use in adults and pediatric patients aged 9 months and older for the topical treatment of impetigo (up to 100 cm 2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) due to Staphylococcus aureus (methicillin-susceptible isolates ... Read moreTopibac 1% is indicated for use in adults and pediatric patients aged 9 months and older for the topical treatment of impetigo (up to 100 cm 2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) due to Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes. Safety in patients younger than 9 months has not been established. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Topibac 1% and other antibacterial drugs, Topibac 1% should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.
Theropeutic Class
Topical Antibiotic preparations
Pharmacology
Topibac 1% is a semisynthetic derivative of the compound pleuromutilin.
Absorption
In vitro activity of Topibac 1% against isolates of Staphylococcus aureus as well as Streptococcus pyogenes has been demonstrated. Topibac 1% selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that is different from that of other antibiotics.
Distribution
This binding site involves ribosomal protein L3 and is in the region of the ribosomal P-site and peptidyl transferase center. By virtue of binding to this site, pleuromutilins inhibit peptidyl transfer, block P-site interactions and prevent the normal formation of active 50S ribosomal subunits.
Metabolism
Topibac 1% demonstrates no in vitro target-specific cross-resistance with other classes of antibiotics.
Dosage & Administration of Topibac 1%
Apply a thin layer of Topibac 1% to the affected area (up to 100 cm2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) twice daily for 5 days.The treated area may be covered with a sterile bandage or gauze dressing if desired.
Dosage of Topibac 1%
A thin layer of Topibac should be applied to the affected area (up to 100 cm2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) twice daily for 5 days. The treated area may be covered with a sterile bandage or gauze dressing if desired.
Interaction of Topibac 1%
The effect of concurrent application of Topibac 1% and other topical products to the same area of skin has not been studied.
Contraindications
Contraindicated in patients with hypersensitivity of any ingredient of this preparation.
Side Effects of Topibac 1%
Adverse effects: Application site irritation (<2% of patients may experience).
Pregnancy & Lactation
Pregnancy Category B. It is not known whether Topibac 1% is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this product is administered to a nursing woman.
Precautions & Warnings
Local Irritation: In the event of sensitization or severe local irritation from Topibac 1%, usage should be discontinued. Not for Systemic or Mucosal Use: Topibac 1% is not intended for ingestion or for oral, intranasal, ophthalmic, or intravaginal use.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Drug Classes
Topical Antibiotic preparations
Mode Of Action
Topibac 1% selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that is different from that of other antibiotics. This binding site involves ribosomal protein L3 and is in the region of the ribosomal P-site and peptidyl transferase center. By virtue of binding to this site, pleuromutilins inhibit peptidyl transfer, block P-site interactions, and prevent the normal formation of active 50S ribosomal subunits. Topibac 1% is bacteriostatic against Staphylococcus aureus and Streptococcus pyogenes at the Topibac 1% in vitro minimum inhibitory concentration (MIC) for these organisms.
Pregnancy
Pregnancy Category B. It is not known whether Topibac 1% is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Topibac 1% is administered to a nursing woman.
Frequently Asked Questions
What is Topibac 1% used for?
Retapamulin is indicated for use in adults and pediatric patients aged 9 months and older for the topical treatment of impetigo (up to 100 cm 2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) due to Staphylococcus aureus (methicillin-susceptible isolates ... Read moreRetapamulin is indicated for use in adults and pediatric patients aged 9 months …
What is the dosage of Topibac 1%?
A thin layer of Topibac should be applied to the affected area (up to 100 cm2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) twice daily for 5 days. The treated area may be covered with a sterile bandage or gauze dressing if desired.
What are the side effects of Topibac 1%?
Adverse effects: Application site irritation (<2% of patients may experience).
Who should not take Topibac 1%?
Contraindicated in patients with hypersensitivity of any ingredient of this preparation.
What precautions should be taken with Topibac 1%?
Local Irritation: In the event of sensitization or severe local irritation from Retapamulin, usage should be discontinued. Not for Systemic or Mucosal Use: Retapamulin is not intended for ingestion or for oral, intranasal, ophthalmic, or intravaginal use.
Is Topibac 1% safe during pregnancy and breastfeeding?
Pregnancy Category B. It is not known whether Retapamulin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this product is administered to a nursing woman.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.