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Urinide1 mg
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Medicine overview
Indications of Urinide 1 mg
Urinide 1 mg is indicated for the treatment of edema associated with- Congestive heart failureHepatic ascites andRenal disease including the nephrotic syndrome
Theropeutic Class
Loop diuretics
Pharmacology
Urinide 1 mg is a loop diuretic of the sulfamyl category to treat heart failure.
Absorption
The main difference between the two substances is in bioavailability.
Distribution
It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect.
Excretion
There is however no reason not to use Urinide 1 mg as a first choice drug. Urinide 1 mg is 40 times more potent than furosemide (for patients with normal renal function). Urinide 1 mg interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Urinide 1 mg appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis.
Dosage & Administration of Urinide 1 mg
Oral
Dosage:1 mg in the morning , repeated after 6-8 hours if necessary, In severe cases , 5 mg daily increased by 5 mg every 12-24 hours according to response
Notes:Elderly , 500 micrograms daily may be sufficient
Parenteral
Dosage:By IV Injection: 1-2 mg, repeated after 20 minutes if necessary
Notes:Elderly, 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient
By IV Infusion
Dosage:2-5 mg over 30-60 minutes
Notes:Elderly, 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient
By IM Injection
Dosage:1 mg initially then adjusted according to response , Elderly 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient
| Condition | Dosage | Notes |
|---|---|---|
| Oral | 1 mg in the morning , repeated after 6-8 hours if necessary, In severe cases , 5 mg daily increased by 5 mg every 12-24 hours according to response | Elderly , 500 micrograms daily may be sufficient |
| Parenteral | By IV Injection: 1-2 mg, repeated after 20 minutes if necessary | Elderly, 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient |
| By IV Infusion | 2-5 mg over 30-60 minutes | Elderly, 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient |
| By IM Injection | 1 mg initially then adjusted according to response , Elderly 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient |
Dosage of Urinide 1 mg
Oral
Dosage:1 mg in the morning , repeated after 6-8 hours if necessary, In severe cases , 5 mg daily increased by 5 mg every 12-24 hours according to response
Notes:Elderly , 500 micrograms daily may be sufficient
Parenteral
Dosage:By IV Injection: 1-2 mg, repeated after 20 minutes if necessary
Notes:Elderly, 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient
By IV Infusion
Dosage:2-5 mg over 30-60 minutes
Notes:Elderly, 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient
By IM Injection
Dosage:1 mg initially then adjusted according to response , Elderly 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient
| Condition | Dosage | Notes |
|---|---|---|
| Oral | 1 mg in the morning , repeated after 6-8 hours if necessary, In severe cases , 5 mg daily increased by 5 mg every 12-24 hours according to response | Elderly , 500 micrograms daily may be sufficient |
| Parenteral | By IV Injection: 1-2 mg, repeated after 20 minutes if necessary | Elderly, 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient |
| By IV Infusion | 2-5 mg over 30-60 minutes | Elderly, 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient |
| By IM Injection | 1 mg initially then adjusted according to response , Elderly 500 micrograms (1 ml of Urinide 1 mg) daily may be sufficient |
Interaction of Urinide 1 mg
Concomitant use of Urinide 1 mg may potentiate the effects of antihypertensive drugs. It shows a tendency to increase the excretion of potassium which can lead to an increase in the sensitivity of the myocardium to the toxic effects of digitalis. As with other diuretics, Urinide 1 mg may cause an increase in blood uric acid.
Contraindications
Loop diuretics should be avoided in severe hypokalaemia, severe hyponatraemia, anuria, comatose and precomatose states associated with liver cirrhosis and in renal failure.
Side Effects of Urinide 1 mg
The side effects of Urinide 1 mg include: headache, dizziness, fatigue, postural hypotension and gastrointestinal symptoms. Various skin reactions, photosensitivity reactions and metabolic disturbances, including reduced glucose tolerance are less frequent. Electrolyte disturbances can occur especially during long term treatment.
Pregnancy & Lactation
Pregnancy Category C. There are no adequate and well controlled studies in pregnant woman. It is not known wheather this drug is excreted in human milk.
Precautions & Warnings
Serum potassium should be measured periodically and potassium supplements or potassium sparing diuretics added if necessary.
Overdose Effects of Urinide 1 mg
Symptoms would be those caused by excessive diuresis. Empty stomach by gastric lavage or emesis.
Storage Conditions
Store in a cool & dry place. Protect from light.
Use In Special Populations
Paediatric use: Safety and effectiveness in paediatric patients below the age of 18 have not been established.
Drug Classes
Loop diuretics
Mode Of Action
Urinide 1 mg is a loop diuretic of the sulfamyl category to treat heart failure. It is often used in patients in whom high doses of furosemide are ineffective. There is however no reason not to use Urinide 1 mg as a first choice drug. The main difference between the two substances is in bioavailability. It is said to be a more predictable diuretic, meaning that the predictable absorption is reflected in a more predictable effect. Urinide 1 mg is 40 times more potent than furosemide (for patients with normal renal function).Urinide 1 mg interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Urinide 1 mg appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis.
Pregnancy
Pregnancy Category C. There are no adequate and well controlled studies in pregnant woman. It is not known wheather this drug is excreted in human milk.
Pediatric Uses
Paediatric use: Safety and effectiveness in paediatric patients below the age of 18 have not been established.
Frequently Asked Questions
What is Urinide 1 mg used for?
Bumetanide is indicated for the treatment of edema associated with- Congestive heart failure, Hepatic ascites and, Renal disease including the nephrotic syndrome
What is the dosage of Urinide 1 mg?
Oral: 1 mg in the morning , repeated after 6-8 hours if necessary, In severe cases , 5 mg daily increased by 5 mg every 12-24 hours according to response. Elderly , 500 micrograms daily may be sufficient. Parenteral: By IV Injection: 1-2 mg, repeated after 20 minutes if necessary. Elderly, 500 micrograms (1 ml of Bumetanide) daily may be sufficient. By IV Infusion: 2-5 mg over 30-60 minutes.Elderl…
What are the side effects of Urinide 1 mg?
The side effects of Bumetanide include: headache, dizziness, fatigue, postural hypotension and gastrointestinal symptoms. Various skin reactions, photosensitivity reactions and metabolic disturbances, including reduced glucose tolerance are less frequent. Electrolyte disturbances can occur especially during long term treatment.
Who should not take Urinide 1 mg?
Loop diuretics should be avoided in severe hypokalaemia, severe hyponatraemia, anuria, comatose and precomatose states associated with liver cirrhosis and in renal failure.
What precautions should be taken with Urinide 1 mg?
Serum potassium should be measured periodically and potassium supplements or potassium sparing diuretics added if necessary.
Is Urinide 1 mg safe during pregnancy and breastfeeding?
Pregnancy Category C. There are no adequate and well controlled studies in pregnant woman. It is not known wheather this drug is excreted in human milk.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.