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Medicine overview
Indications of Valovir 1 gm
Valovir 1 gm is indicated for the treatment of Herpes zoster (shingles). It is indicated for the treatment or suppression of genital herpes in immuno-competent individuals and for the suppression of recurrent genital herpes in HIV infected individuals. It is also indicated for the treatment of cold sores (Herpes labialis).
Theropeutic Class
Herpes simplex & Varicella-zoster virus infections
Pharmacology
Valovir 1 gm is the hydrochloride salt of L-valyl ester of the antiviral drug acyclovir. Valovir 1 gm is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection. Valovir 1 gm lessens the symptoms of infections and shortens the length of time of sickness. Valovir 1 gm is used in the treatment and suppression of genital herpes, shingles and cold sores.
Dosage & Administration of Valovir 1 gm
Adult Dosage:
Cold Sores: 2 grams every 12 hours for 1 day
Genital Herpes:
Initial episode: 1 gram twice daily for 10 days
Recurrent episodes: 500 mg twice daily for 3 days Suppressive therapy
Immunocompetent patients: 1 gram once daily
Alternate dose in patients with < 9 recurrences/year: 500 mg once daily
HIV-infected patients: 500 mg twice daily
Reduction of transmission: 500 mg once daily
Herpes Zoster: 1 gram 3 times daily for 7 days
Pediatric Dosage:
Cold Sores (> 12 years of age): 2 grams every 12 hours for 1 day
Chickenpox (2 to < 18 years of age): 20 mg/kg 3 times daily for 5 days; not to exceed 1 gram 3 times daily
Dosage of Valovir 1 gm
Adult Dosage:
Cold Sores: 2 grams every 12 hours for 1 day
Genital Herpes:
Initial episode: 1 gram twice daily for 10 days
Recurrent episodes: 500 mg twice daily for 3 days Suppressive therapy
Immunocompetent patients: 1 gram once daily
Alternate dose in patients with < 9 recurrences/year: 500 mg once daily
HIV-infected patients: 500 mg twice daily
Reduction of transmission: 500 mg once daily
Herpes Zoster: 1 gram 3 times daily for 7 days
Pediatric Dosage:
Cold Sores (> 12 years of age): 2 grams every 12 hours for 1 day
Chickenpox (2 to < 18 years of age): 20 mg/kg 3 times daily for 5 days; not to exceed 1 gram 3 times daily
Interaction of Valovir 1 gm
No dosage adjustment is recommended when Valovir 1 gm is coadministered with digoxin, antacids, thiazide diuretics, cimetidine or probenecid in subjects with normal renal function.
Contraindications
Valovir 1 gm is contraindicated in patients with a known hypersensitivity or intolerance to Valovir 1 gm, acyclovir, or any component of the formulation.
Side Effects of Valovir 1 gm
The most frequently reported adverse reactions were nausea (15%), headache (14%), vomiting (6%), dizziness (3%) and abdominal pain (3%).
Pregnancy & Lactation
Pregnancy category B. Valovir 1 gm was not teratogenic in rats or rabbits at 10 and 7 times human plasma levels, respectively, during the period of major organogenesis. There is no adequate and well-controlled studies of Valovir 1 gm in pregnant women. Nursing Mothers: Unchanged Valovir 1 gm was not detected in maternal serum, breast milk, or infant urine. Valovir 1 gm should be administered to a nursing mother with caution and only when indicated.
Precautions & Warnings
Dosage reduction is recommended when administering Valovir 1 gm to patients with renal impairment. Similar caution should be exercised when administering Valovir 1 gm to geriatric patients and patients receiving potentially nephrotoxic agents. The safety and efficacy of Valovir 1 gm have not been established in immuno compromised patients other than for the suppression of genital herpes in HIVinfected patients
Storage Conditions
Store in cool & dry place, away from children.
Use In Special Populations
Pediatric Use: Safety and effectiveness of Valovir 1 gm in pre-pubertal pediatric patients have not been established. Elderly Use (Over 65 yr.): Elderly patients may require a dose reduction of Valovir 1 gm due to a low body weight or disorders (renal, CNS etc.) associated with aging.
Drug Classes
Herpes simplex & Varicella-zoster virus infections
Mode Of Action
Valovir 1 gm is the hydrochloride salt of L-valyl ester of the antiviral drug acyclovir. Valovir 1 gm is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection. Valovir 1 gm lessens the symptoms of infections and shortens the length of time of sickness. Valovir 1 gm is used in the treatment and suppression of genital herpes, shingles and cold sores.
Pregnancy
Pregnancy category B. Valovir 1 gm was not teratogenic in rats or rabbits at 10 and 7 times human plasma levels, respectively, during the period of major organogenesis. There is no adequate and well-controlled studies of Valovir 1 gm in pregnant women. Nursing Mothers: Unchanged Valovir 1 gm was not detected in maternal serum, breast milk, or infant urine. Valovir 1 gm should be administered to a nursing mother with caution and only when indicated.
Pediatric Uses
Pediatric Use: Safety and effectiveness of Valovir 1 gm in pre-pubertal pediatric patients have not been established. Elderly Use (Over 65 yr.): Elderly patients may require a dose reduction of Valovir 1 gm due to a low body weight or disorders (renal, CNS etc.) associated with aging.
Frequently Asked Questions
What is Valovir 1 gm used for?
Valovir 1 gm is indicated for the treatment of Herpes zoster (shingles). It is indicated for the treatment or suppression of genital herpes in immuno-competent individuals and for the suppression of recurrent genital herpes in HIV infected individuals. It is also indicated for the treatment of cold sores (Herpes labialis).
What is the dosage of Valovir 1 gm?
Adult Dosage: Cold Sores: 2 grams every 12 hours for 1 day Genital Herpes: Initial episode: 1 gram twice daily for 10 days Recurrent episodes: 500 mg twice daily for 3 days Suppressive therapy Immunocompetent patients: 1 gram once daily Alternate dose in patients with 12 years of age): 2 grams every 12 hours for 1 day Chickenpox (2 to < 18 years of age): 20 mg/kg 3 times daily for 5 days; not to e…
What are the side effects of Valovir 1 gm?
The most frequently reported adverse reactions were nausea (15%), headache (14%), vomiting (6%), dizziness (3%) and abdominal pain (3%).
Who should not take Valovir 1 gm?
Valovir 1 gm is contraindicated in patients with a known hypersensitivity or intolerance to Valovir 1 gm, acyclovir, or any component of the formulation.
What precautions should be taken with Valovir 1 gm?
Dosage reduction is recommended when administering Valovir 1 gm to patients with renal impairment. Similar caution should be exercised when administering Valovir 1 gm to geriatric patients and patients receiving potentially nephrotoxic agents. The safety and efficacy of Valovir 1 gm have not been established in immuno compromised patients other than for the suppression of genital herpes in HIVinfe…
Is Valovir 1 gm safe during pregnancy and breastfeeding?
Pregnancy category B. Valovir 1 gm was not teratogenic in rats or rabbits at 10 and 7 times human plasma levels, respectively, during the period of major organogenesis. There is no adequate and well-controlled studies of Valovir 1 gm in pregnant women. Nursing Mothers: Unchanged Valovir 1 gm was not detected in maternal serum, breast milk, or infant urine. Valovir 1 gm should be administered to a …
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.