Vasocil

Vasocil100 mg

Tablet

Cilostazol

Ibn-Sina Pharmaceuticals Ltd.

Product Code : 17819
MRP 12.00
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Medicine overview

Indications of Vasocil 100 mg

Vasocil 100 mg is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance.

Theropeutic Class

Peripheral Vasodilator drugs: Intermittent Claudication

Pharmacology

Vasocil 100 mg is a preparation of Vasocil 100 mg which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.

Dosage & Administration of Vasocil 100 mg

The recommended dosage of Vasocil 100 mg is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.

Dosage of Vasocil 100 mg

The recommended dosage of Vasocil 100 mg is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.Pediatric use: The safety and effectiveness of Vasocil 100 mg in pediatric patients have not been established.

Interaction of Vasocil 100 mg

Pharmacokinetic studies have demonstrated that Omeprazole and Erythromycin significantly increased the systemic exposure of Vasocil 100 mg and/or its major metabolites. Population pharmacokinetic studies showed higher concentrations of Vasocil 100 mg among patients concurrently treated with Diltiazem.

Contraindications

Vasocil 100 mg is contraindicated in patients with congestive heart failure of any severity. Vasocil 100 mg is also contraindicated in patients with known or suspected hypersensitivity to any of its components.

Side Effects of Vasocil 100 mg

The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.

Pregnancy & Lactation

There are no adequate and well controlled studies in pregnant women. Transfer of Vasocil 100 mg into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Vasocil 100 mg.

Precautions & Warnings

Vasocil 100 mg should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Vasocil 100 mg and Clopidogrel.

Overdose Effects of Vasocil 100 mg

Severe headache, diarrhoea, hypotension, tachycardia, and possibly cardiac arrhythmias. Careful observation and supportive treatment are recommended.

Storage Conditions

Store in a cool & dry place, protected from light and moisture.

Use In Special Populations

Paediatric use: The safety and effectiveness of Vasocil 100 mg in paediatric patients have not been established.

Drug Classes

Peripheral Vasodilator drugs: Intermittent Claudication

Mode Of Action

Vasocil 100 mg is a preparation of Vasocil 100 mg which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.

Pregnancy

There are no adequate and well controlled studies in pregnant women. Transfer of Vasocil 100 mg into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Vasocil 100 mg.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.