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Corlift10 mg
Ziska Pharmaceuticals Ltd.
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Medicine overview
Indications of Verigat 10 mg
Verigat 10 mg is indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization following a hospitalization for heart failure or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction less than 45%.
Dosage of Verigat 10 mg
Recommended Dosage: The recommended starting dose of Verigat 10 mg is 2.5 mg orally once daily with food. Double the dose of Verigat 10 mg approximately every 2 weeks to reach the target maintenance dose of 10 mg once daily, as tolerated by the patient. For patients who are unable to swallow whole tablets, Verigat 10 mg may be crushed and mixed with water immediately before administration.Pregnancy Testing in Females of Reproductive Potential: Obtain a pregnancy test in females of reproductive potential prior to initiating treatment with Verigat 10 mg.Pediatric Use: Safety and effectiveness of Verigat 10 mg have not been established in pediatric patients.
Interaction of Verigat 10 mg
Other Soluble Guanylate Cyclase Stimulators: Verigat 10 mg is contraindicated in patients with concomitant use of another soluble guanylate cyclase (sGC) stimulator.PDE-5 Inhibitors: Concomitant use of Verigat 10 mg with PDE-5 inhibitors is not recommended because of the potential for hypotension.
Contraindications
Verigat 10 mg is contraindicated in patients with concomitant use of another soluble guanylate cyclase (sGC) stimulator. Verigat 10 mg is contraindicated in pregnancy.
Precautions & Warnings
Based on data from animal reproduction studies, Verigat 10 mg may cause fetal harm when administered to a pregnant woman. Advise females of reproductive potential of the potential risk to a fetus. Obtain a pregnancy test before the start of treatment. Advise females of reproductive potential to use effective contraception during treatment with Verigat 10 mg and for at least one month after the final dose.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Drug Classes
Stimulator of soluble guanylate cyclase
Mode Of Action
Verigat 10 mg is a stimulator of soluble guanylate cyclase (sGC), an important enzyme in the nitric oxide (NO) signaling pathway. When NO binds to sGC, the enzyme catalyzes the synthesis of intracellular cyclic guanosine monophosphate (cGMP), a second messenger that plays a role in the regulation of vascular tone, and cardiac contractility, and cardiac remodeling. Heart failure is associated with impaired synthesis of NO and decreased activity of sGC, which may contribute to myocardial and vascular dysfunction. By directly stimulating sGC, independently of and synergistically with NO, Verigat 10 mg augments levels of intracellular cGMP, leading to smooth muscle relaxation and vasodilation.
Pregnancy
Based on data from animal reproduction studies, Verigat 10 mg may cause fetal harm when administered to a pregnant woman and is contraindicated during pregnancy. There are no data on the presence of Verigat 10 mg in human milk, the effects on the breastfed infant, or the effects on milk production. Verigat 10 mg is present in the milk of lactating rats and it is likely that Verigat 10 mg or its metabolites are present in human milk. Because of the potential for serious adverse reactions in breastfed infants from Verigat 10 mg, advise women not to breastfeed during treatment with Verigat 10 mg.
Frequently Asked Questions
What is Verigat 10 mg used for?
Verigat 10 mg is indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization following a hospitalization for heart failure or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction less than 45%.
What is the dosage of Verigat 10 mg?
Recommended Dosage: The recommended starting dose of Verigat 10 mg is 2.5 mg orally once daily with food. Double the dose of Verigat 10 mg approximately every 2 weeks to reach the target maintenance dose of 10 mg once daily, as tolerated by the patient. For patients who are unable to swallow whole tablets, Verigat 10 mg may be crushed and mixed with water immediately before administration.Pregnanc…
Who should not take Verigat 10 mg?
Verigat 10 mg is contraindicated in patients with concomitant use of another soluble guanylate cyclase (sGC) stimulator. Verigat 10 mg is contraindicated in pregnancy.
What precautions should be taken with Verigat 10 mg?
Based on data from animal reproduction studies, Verigat 10 mg may cause fetal harm when administered to a pregnant woman. Advise females of reproductive potential of the potential risk to a fetus. Obtain a pregnancy test before the start of treatment. Advise females of reproductive potential to use effective contraception during treatment with Verigat 10 mg and for at least one month after the fin…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.