Xalcort

Xalcort6 mg

Tablet

Deflazacort

Beacon Pharmaceuticals PLC

Product Code : 18400
MRP 10.00
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Medicine overview

Indications of Xalcort 6 mg

Xalcort 6 mg is indicated in- Anaphylaxis, asthma, severe hypersensitivity reactions Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease (other than systemic sclerosis), polyartritis nodosa, sarcoidosis ... Read moreXalcort 6 mg is indicated in- Anaphylaxis, asthma, severe hypersensitivity reactions Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease (other than systemic sclerosis), polyartritis nodosa, sarcoidosis Pemphigus,bullous pemphigoid, pyoderma gangrenosum Minimal change nephrotic syndrome, acute interstitial nephritis Rheumatic carditis Ulcerative colitis, Crohn's disease Uveitis, optic neuritis Autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma Immune suppression in transplantation

Theropeutic Class

Glucocorticoids

Pharmacology

Xalcort 6 mg provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme which is responsible for prostaglandin synthesis. Besides Xalcort 6 mg decreases the release of certain chemicals that are important in the immune system. By decreasing the release of these chemicals Xalcort 6 mg provides immunosuppressive action.

Dosage & Administration of Xalcort 6 mg

Adults: For acute disorders: up to 120 mg/day Xalcort 6 mg may need to be given initially. Maintenance doses in most conditions are within the range 3-18 mg/day. Rheumatoid arthritis: The maintenance dose is usually within the range 3-18 mg/day. The smallest effective dose should be used and increased if necessary. Bronchial asthma: In the treatment of an acute attack, high doses of 48-72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled. For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms. Other conditions: The dose of Xalcort 6 mg depends on clinical need titrated to the lowest effective dose for maintenance. Starting doses may be estimated on the basis of ratio of 5 mg prednisone or prednisolone to 6 mg Xalcort 6 mg. Children: Alternate day administration may be appropriate.  Doses of Xalcort 6 mg usually lie in the range 0.25-1.5 mg/kg/day. The following ranges provide general guidance: Juvenile chronic arthritis: The usual maintenance dose is between 0.25 to 1.0 mg/kg/day. Nephrotic syndrome: Initial dose of usually 1.5 mg/kg/day followed by down titration according to clinical need. Bronchial asthma: The initial dose should be between 0.25 - 1.0 mg/kg on alternate days. Xalcort 6 mg withdrawal: In patients who have received more than physiological doses of systemic corticosteroids (approximately 9 mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt. How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced.

Dosage of Xalcort 6 mg

Adults- For acute disorders: Up to 120 mg/day Xalcort 6 mg may need to be given initially. Maintenance doses in most conditions are within the range of 3-18 mg/day. Rheumatoid arthritis: The maintenance dose is usually within the range of 3-18 mg/day. The smallest effective dose should be used and increased if necessary. Bronchial asthma: In the treatment of an acute attack, high doses of 48-72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled. For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms. Other conditions: The dose of Xalcort 6 mg depends on clinical need titrated to the lowest effective dose for maintenance. Starting doses may be estimated on the basis of ratio of 5 mg prednisone or prednisolone to 6 mg. Children: There has been limited exposure of children to Xalcort 6 mg in clinical trials. In children, the indications for glucocorticoids arethe same as for adults, but it is important that the lowest effective dosage is used. Alternate day administration may be appropriate. Doses of Xalcort 6 mg usually lie in the range 0.25-1.5 mg/kg/day. The following ranges provide general guidance: Juvenile chronic arthritis: The usual maintenance dose is between 0.25-1.0 mg/kg/day. Nephrotic syndrome: Initial dose of usually 1.5 mg/kg/day followed by down titration according to clinical need. Bronchial asthma: On the basis of the potency ratio, the initial dose should be between 0.25-1.0 mg/kg on alternate days. Xalcort 6 mg withdrawal: In patients who have received more than physiological doses of systemic corticosteroids (approximately 9 mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt. How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced.

Interaction of Xalcort 6 mg

Xalcort 6 mg is metabolized in the liver. It is recommended to increase the maintenance dose of Xalcort 6 mg if drugs which are liver enzyme inducers are co-administered, e.g. rifampicin, rifabutin, carbamazepine, phenobarbitone, phenytoin, primidone and aminoglutethimide. For drugs which inhibit liver enzymes, (e.g. ketoconazole) it may be possible to reduce the maintenance dose of Xalcort 6 mg.

Contraindications

Hypersensitivity to or any of the ingredients. Patients receiving live virus immunization.

Side Effects of Xalcort 6 mg

GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances; susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent Ml, thromboembolism.

Pregnancy & Lactation

Use in pregnancy: Xalcort 6 mg does cross the placenta. When administered for prolonged periods or repeatedly during pregnancy, corticosteroids may increase the risk of intra-uterine growth retardation. As with all drugs, corticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks.Use in lactation: Corticosteroids are excreted in breast milk. Doses up to 50 mg daily of Xalcort 6 mg are unlikely to cause systemic effects in the infant.

Precautions & Warnings

The following clinical conditions require special caution and frequent patient monitoring is necessary- Cardiac disease or congestive heart failure (except in the presence of active rheumatic carditis), hypertension, thromboembolic disorders. Glucocorticoids can cause salt and water retention and increased excretion of potassium. Dietary salt restriction and potassium supplementation may be necessary. Gastritis or oesophagitis, diverticulitis, ulcerative colitis if there is the probability of impending perforation, abscess or pyogenic infections, fresh intestinal anastomosis, active or latent peptic ulcer. Diabetes mellitus or family history, osteoporosis, myasthenia gravis, renal insufficiency. Emotional instability or psychotic tendency, epilepsy. Previous corticosteroid-induced myopathy. Liver failure. Hypothyroidism and cirrhosis, which may increase the glucocorticoid effect. Ocular herpes simplex because of possible corneal perforation.

Overdose Effects of Xalcort 6 mg

In patients who have received more than physiological doses of systemic corticosteroids (approximately 9mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt. How dose reduction should becarried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced.

Storage Conditions

Store in a cool (below 25°C) and dry place, protected from light & moisture. Keep out of the reach of children.

Use In Special Populations

Elderly: In elderly patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.Hepatic impairment: In patients with hepatic impairment, blood levels of Xalcort 6 mg may be increased. Therefore the dose of Xalcort 6 mg should be carefully monitored and adjusted to the minimum effective dose.Renal impairment: In renal impaired patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.

Drug Classes

Glucocorticoids

Mode Of Action

Xalcort 6 mg provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme which is responsible for prostaglandin synthesis. Besides Xalcort 6 mg decreases the release of certain chemicals that are important in the immune system. By decreasing the release of these chemicals Xalcort 6 mg provides immunosuppressive action.

Pregnancy

Pregnancy: Xalcort 6 mg does cross the placenta. However, when administered for prolonged periods or repeatedly during pregnancy, corticosteroids may increase the risk of intrauterine growth retardation. As with all drugs, corticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks.Nursing Mother: Corticosteroids are excreted in breast milk, although no data are available for Xalcort 6 mg. Doses of up to 50 mg daily of Xalcort 6 mg are unlikely to cause systemic effects in the infant. Infants of mothers taking higher doses than this may have a degree of adrenal suppression but the benefits of breastfeeding are likely to outweigh any theoretical risk.

Pediatric Uses

Hepatic Impairment: In patients with hepatic impairment, blood levels of may be increased. Therefore the dose of Xalcort 6 mg should be carefully monitored and adjusted to the minimum effective dose.Renal Impairment: In renally impaired patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.Elderly: In elderly patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary. The common adverse effects of systemic corticosteroids may be associated with more serious consequences in old age.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.