Zentixol D200 mg/ml
Injection
Medicine overview
Indications of Zentixol D 200 mg/ml
Theropeutic Class
Pharmacology
Zentixol D 200 mg/ml, a thioxanthene derivative, has high affinity for both dopamine D1 receptors and dopamine D2 receptors.
Zentixol D 200 mg/ml also has high affinity for α1 -adrenergic and 5 HT2 receptors.
It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and α2 -adrenergic receptors.
Dosage & Administration of Zentixol D 200 mg/ml
| Condition | Dosage | Notes |
|---|---|---|
| Zentixol D 200 mg/ml Tablets | When initiating treatment with Zentixol D 200 mg/ml tablets, it is recommended that the drug be given in divided doses (BID or TID) | During the maintenance phase of treatment Zentixol D 200 mg/ml tablets may be given as a single nighttime dose. For acute psychosis, the usual starting dose is 10-50 mg/day, which may be increased by 10-20 mg every 2-3 days, according to the patient’s response. The usual therapeutic range is 20 mg to 60 mg daily. However, as with other antipsychotic drugs, some patients may require lower, while others may require higher dosage in order to obtain optimal benefit. Daily dosage higher than 100 mg is not recommended. For maintenance therapy, dosage should be reduced to the lowest level compatible with symptom control. The usual maintenance dose is 20-40 mg/day |
| Zentixol D 200 mg/ml Acuphase | Dosage should be individually adjusted according to the patient’s condition | The usual dose is 50-150 mg (1-3 ml) administered intramuscularly and repeated if necessary, at intervals of 2-3 days. Some patients may need an additional injection 1 or 2 days after the first injection |
| Zentixol D 200 mg/ml Depot | Close supervision is required during the period following initiation of Zentixol D 200 mg/ml Depot treatment, in order to minimize the risk of over-medication or insufficient suppression of psychotic symptoms | Supplemental oral antipsychotic medication may be required in diminishing dosage during this period. The usual maintenance dose is 150-300 mg intramuscularly, every 2-4 weeks. Some patients may require higher or lower doses, or shorter intervals between doses |
Interaction of Zentixol D 200 mg/ml
Contraindications
Side Effects of Zentixol D 200 mg/ml
Pregnancy & Lactation
Precautions & Warnings
Overdose Effects of Zentixol D 200 mg/ml
Storage Conditions
Use In Special Populations
Frequently Asked Questions
What is Zentixol D 200 mg/ml used for?
Zuclopenthixol is indicated for the management of the manifestations of schizophrenia. This is intended for the initial treatment of acute psychotic episodes or exacerbation of psychosis associated with schizophrenia.
What is the dosage of Zentixol D 200 mg/ml?
Zuclopenthixol Tablets: When initiating treatment with Zuclopenthixol tablets, it is recommended that the drug be given in divided doses (BID or TID). During the maintenance phase of treatment Zuclopenthixol tablets may be given as a single nighttime dose. For acute psychosis, the usual starting dose is 10-50 mg/day, which may be increased by 10-20 mg every 2-3 days, according to the patient’s res…
What are the side effects of Zentixol D 200 mg/ml?
Common side effects are Racing heart (tachycardia), a sensation of a rapid, forceful, or irregular beating of the heart (palpitations) Tremor, twisting or repetitive movements or abnormal postures due to sustained muscle contractions (dystonia), increased muscle stiffness (hypertonia).
Who should not take Zentixol D 200 mg/ml?
Acute alcohol, barbiturate or opiate intoxication. CNS depression due to any cause, comatose states, suspected or established subcortical brain damage or circulatory collapse. Patients with known hypersensitivity to thioxanthenes, zuclopenthixol or to any ingredient in the formulation or component of the container.
What precautions should be taken with Zentixol D 200 mg/ml?
Caution should be taken if- you have used zuclopenthixol or any other treatment for schizophrenia before and if you had any problems you are taking any other prescription or non-prescription medicines you are pregnant or thinking of becoming pregnant, or if you are breast-feeding you regularly drink a lot of alcohol you have any liver problems, Parkinson’s disease or have ever had seizures you hav…
Is Zentixol D 200 mg/ml safe during pregnancy and breastfeeding?
The safe use of zuclopenthixol during pregnancy has not been established. Zuclopenthixol is excreted in human milk. The safe use of zuclopenthixol during lactation has not been established.
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.