Abdorin

Abdorin10 mg/5 ml

Dicycloverine Hydrochloride

Opsonin Pharma Ltd.

Product Code : 81
MRP 30.11
10% Off
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Section

Medicine overview

Indications of Abdorin 10 mg/5 ml

Dicycloverine is indicated in: Functional bowel/irritable bowel syndrome Urinary incontinence secondary to unstable detrusor muscle Infantile colic GIT spasm Colicky abdominal pain Diverticulitis Abdominal colic

Theropeutic Class

Anticholinergics (antimuscarinics)/ Anti-spasmodics

Pharmacology

Abdorin 10 mg/5 ml is an antispasmodic and anticholinergic (antimuscarinic) agent. Dicycloverine relieves smooth muscle spasm of the gastrointestinal tract, urinary bladder & ureter. It works at specific receptors, called cholinergic (or muscarinic) receptors, located on the involuntary muscle in the walls of the gut. As antispasmodic drug Dicycloverine causes the gut muscle to relax, relieving the pain of colic produced by gut muscle contraction and spasm. Also it has direct musculotropic action.

Dosage & Administration of Abdorin 10 mg/5 ml

Adult: 10-20 mg three times dailyChildren (2-12 years): 10 mg three times dailyInfant (6 months-2 years): 5-10 mg (1/2-1 teaspoonful syrup) three times daily, 15 minutes before feeds. Infant (under 6 months): Dicycloverine should not be used under 6 month of age.

Dosage of Abdorin 10 mg/5 ml

For oral dosage forms: Adults:10 to 20 mg three times a day. Children over 6 months of age: 5 to 10 mg three times a day. For injectable dosage form: Adults: Intramuscular injection. Not for intravenous use. The recommended intramuscular dose is 80 mg daily (in 4 equally divided doses). Oral dicycloverine Hydrochloride should be started as soon as possible and the intramuscular form should not be used for periods longer than 1 or 2 days. Children: Dose must be determined by the doctor.

Interaction of Abdorin 10 mg/5 ml

The following agents may increase certain actions or side effects of anticholinergic drugs: amantadine, antiarrythmic agent of class 1 (e.g. quinidine), antihistamines, antipsychotic agents (e.g. phenothiazines), MAO inhibitors, narcotic analgesics (e.g. meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. Dicycloverine may affect the gastrointestinal absorption of various drugs, such as digoxin, metoclopramide.

Contraindications

Dicycloverine is contraindicated in: Obstructive uropathy Obstructive disease of the gastrointestinal tract Severe ulcerative colitis Reflux esophagitis Unstable cardiovascular status in acute hemorrhage Glaucoma Myasthenia gravis Evidence of prior hypersensitivity to Abdorin 10 mg/5 ml or other ingredients of this formulation Infants less than 6 months of age

Side Effects of Abdorin 10 mg/5 ml

Insomnia, mydriasis, cycloplegia, increased ocular tension, urinary hesitancy, palpitations, dyspnea.

Pregnancy & Lactation

Dicycloverine should be used during pregnancy only if clearly needed. No teratogenic effect was shown in animal study. Since Dicycloverine hydrochloride has been reported to be secreted in human milk. So, Dicycloverine is contraindicated in lactating mother.

Precautions & Warnings

Use with caution in patients with autonomic neuropathy, hepatic or renal disease, ulcerative colitis, coronary heart disease, congestive heart failure, cardiac tachyarrhythmia, hiatal hernia, known or suspected prostatic hypertrophy.

Overdose Effects of Abdorin 10 mg/5 ml

Toxic reaction seldom occurs with dicycloverine. The signs and symptoms of overdosage are headache; nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Drug Classes

Anticholinergics (antimuscarinics)/ Anti-spasmodics

Mode Of Action

Dicycloverine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Chemically, it is [Bicyclohexyl-]1-carboxylic acid, 2-(diethylammo) ethyl ester, hydrochloride. Dicycloverine relieves smooth muscle spasm of the gastrointestinal tract. Dicycloverine HCl Injection is a sterile, pyrogen-free, aqueous solution for intramuscular injection (Not For Intravenous Use). It works at specific receptors, called cholinergic (or muscarinic) receptors, located on the involuntary muscle in the walls of the gut. By binding to these receptors dicycloverine prevents certain chemicals produced by the body from interacting with these receptors. This causes the gut muscle to relax, relieving the pain of colic produced by gut muscle contraction and spasm.

Pregnancy

Pregnancy Category B. Dicycloverine was neither teratogenic nor embryocidal in animal trial. It, like other drugs should be used during pregnancy only if clearly needed. There are no data on the secretion of this drug into breast milk. Dicycloverine should be used cautiously in case of lactating mother.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.