Ibspa10 mg/5 ml

Dicycloverine is indicated in: Functional bowel/irritable bowel syndrome Urinary incontinence secondary to unstable detrusor muscle Infantile colic GIT spasm Colicky abdominal pain Diverticulitis Abdominal colic

Anticholinergics (antimuscarinics)/ Anti-spasmodics

Ibspa 10 mg/5 ml is an antispasmodic and anticholinergic (antimuscarinic) agent. Dicycloverine relieves smooth muscle spasm of the gastrointestinal tract, urinary bladder & ureter. It works at specific receptors, called cholinergic (or muscarinic) receptors, located on the involuntary muscle in the walls of the gut. As antispasmodic drug Dicycloverine causes the gut muscle to relax, relieving the pain of colic produced by gut muscle contraction and spasm. Also it has direct musculotropic action.

Adult: 10-20 mg three times dailyChildren (2-12 years): 10 mg three times dailyInfant (6 months-2 years): 5-10 mg (1/2-1 teaspoonful syrup) three times daily, 15 minutes before feeds. Infant (under 6 months): Dicycloverine should not be used under 6 month of age.

For oral dosage forms: Adults:10 to 20 mg three times a day. Children over 6 months of age: 5 to 10 mg three times a day. For injectable dosage form: Adults: Intramuscular injection. Not for intravenous use. The recommended intramuscular dose is 80 mg daily (in 4 equally divided doses). Oral dicycloverine Hydrochloride should be started as soon as possible and the intramuscular form should not be used for periods longer than 1 or 2 days. Children: Dose must be determined by the doctor.

The following agents may increase certain actions or side effects of anticholinergic drugs: amantadine, antiarrythmic agent of class 1 (e.g. quinidine), antihistamines, antipsychotic agents (e.g. phenothiazines), MAO inhibitors, narcotic analgesics (e.g. meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. Dicycloverine may affect the gastrointestinal absorption of various drugs, such as digoxin, metoclopramide.

Dicycloverine is contraindicated in: Obstructive uropathy Obstructive disease of the gastrointestinal tract Severe ulcerative colitis Reflux esophagitis Unstable cardiovascular status in acute hemorrhage Glaucoma Myasthenia gravis Evidence of prior hypersensitivity to Ibspa 10 mg/5 ml or other ingredients of this formulation Infants less than 6 months of age

Insomnia, mydriasis, cycloplegia, increased ocular tension, urinary hesitancy, palpitations, dyspnea.

Dicycloverine should be used during pregnancy only if clearly needed. No teratogenic effect was shown in animal study. Since Dicycloverine hydrochloride has been reported to be secreted in human milk. So, Dicycloverine is contraindicated in lactating mother.

Use with caution in patients with autonomic neuropathy, hepatic or renal disease, ulcerative colitis, coronary heart disease, congestive heart failure, cardiac tachyarrhythmia, hiatal hernia, known or suspected prostatic hypertrophy.

Toxic reaction seldom occurs with dicycloverine. The signs and symptoms of overdosage are headache; nausea; vomiting; blurred vision; dilated pupils; hot, dry skin; dizziness; dryness of the mouth; difficulty in swallowing; and CNS stimulation.

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Anticholinergics (antimuscarinics)/ Anti-spasmodics

Dicycloverine hydrochloride is an antispasmodic and anticholinergic (antimuscarinic) agent. Chemically, it is [Bicyclohexyl-]1-carboxylic acid, 2-(diethylammo) ethyl ester, hydrochloride. Dicycloverine relieves smooth muscle spasm of the gastrointestinal tract. Dicycloverine HCl Injection is a sterile, pyrogen-free, aqueous solution for intramuscular injection (Not For Intravenous Use). It works at specific receptors, called cholinergic (or muscarinic) receptors, located on the involuntary muscle in the walls of the gut. By binding to these receptors dicycloverine prevents certain chemicals produced by the body from interacting with these receptors. This causes the gut muscle to relax, relieving the pain of colic produced by gut muscle contraction and spasm.

Pregnancy Category B. Dicycloverine was neither teratogenic nor embryocidal in animal trial. It, like other drugs should be used during pregnancy only if clearly needed. There are no data on the secretion of this drug into breast milk. Dicycloverine should be used cautiously in case of lactating mother.