Allygest 5 mg is a synthetic progesterone derivative that is used to treat threatened pregnancies. It can stop occurring premature labor and can help women give birth to a healthy newborn. It stimulates the secretory phase in myometrium, creates conditions for development of fertilized ovum. It has a tocolytic effect; reduces sensitivity of myometrium to oxytocin. It stimulates the development of acinus of mammary glands, secretory activity of trophoblasts, and development of aldosterone by adrenal glands. Allygest 5 mg also has a selection of β-adrenergic effect. In this way, it stimulates the synthesis of the body's placental progesterone, therefore increasing the secretion of placental hormones.

Dosage & Administration of Allygest 5 mg

Intra Uterine Growth Retardation: 1 tablet three times a day at least two months. Dose to be reduced if symptoms improve. Threatened abortion: 1 tablet three times daily until symptoms disappear.Habitual abortion: 1-2 tablets daily as soon as pregnancy is diagnosed. The administration should be continued for at least one month after the end of the critical period.Threatened premature delivery: Dosage must be determined individually. High dosages (up to 40 mg daily) have been used.In case of a missed dose, it should be taken as soon as the patient remembers & she should continue the regular dosing schedule. A double dose is not recommended.

Dosage of Allygest 5 mg

Contraindications

Breast Cancer or history of problem with the breasts like- Nodules,an abnormal Mammogram, or Fibrocystic Diseases. Severe liver disease such as Cholestatic Jaundice or Hepatitis, Hepatic Cell Tumours, Rotor Syndrome and Dubin Jhonson Syndrome. Undiagnosed vaginal bleeding Toxaemia of Pregnancy Crisis Seizures, Migraines

Side Effects of Allygest 5 mg

Treatment with Allygest 5 mg (especially a long term treatment) is known to cause some gastrointestinal complaints such as vomiting, nausea, and sometimes epigastric discomfort.

Pregnancy & Lactation

Allygest 5 mg is specifically designed to be taken during pregnancy. It should be discontinued after delivery as it may affect a nursing infant to a small but noticeable degree.

Precautions & Warnings

Patients with the following conditions should be cautious: Heart disease, congestive heart failure, sick sinus syndrome, coronary artery disease, seizures, epilepsy, renal dysfunction, migraine headaches, or breathing diseases including asthma, emphysema, chronic bronchitis, or COPD, breast-feeding.

Overdose Effects of Allygest 5 mg

Symptoms of overdose may include unusual drowsiness; rapid pulse; fainting; unusual muscle movement or rigidity of the face, neck, or limbs; seizures; and loss of consciousness.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Use In Special Populations

It should not be used for children younger than 16 years old.

Drug Classes

Female Sex hormones

Mode Of Action

Allygest 5 mg has been found to have a relatively weak progestational effect on the human endometrium. To obtain a full secretory endometrium in oestrogen-primed castrated women or to postpone menstruation (with an oestrogen added) in normal ovulating women, doses of Allygest 5 mg were required which were higher than those recommended for the treatment/prevention of abortion.In vitro studies have shown that Allygest 5 mg stimulates the synthesis of progesterone in the human placenta. It also brought about a significant (p/. 0,01) increase in the production of some specific placental enzymes (cystine aminopeptidase and heat-stable alkaline phosphatase).Histological and histochemical changes indicating an increased activity have been found in the placenta, particularly in the syncytiotrophoblast of women with a normal and threatened pregnancy, treated with Allygest 5 mg. The stimulatory effect of Allygest 5 mg on placental function was also suggested by the increased level of placental hormones (pregnanediol, oestriol, HCG and HPL) and enzymes (oxytocinase, CAP) in the maternal urine and plasma, which followed the administration of the drug e.g. in the early weeks as well as in the last trimester of pregnancy.A study in full-term pregnant women revealed that Allygest 5 mg in high doses (up to 100 mg daily) did suppress the intensity of spontaneous uterine contractions, but had no effect on the sensitivity of the uterine muscle to oxytocin, and no adverse effect on the progress of normal delivery.Studies in non-pregnant women with and without endocrinological disorders have shown that Allygest 5 mg has no oestrogenic or androgenic properties and no adverse effects on the adrenal function.No abnormal liver function tests or water and salt retention were observed in healthy female volunteers (non pregnant) who were given Allygest 5 mg.

Pregnancy

Allygest 5 mg is specifically designed to be taken during pregnancy. It should be discontinued after delivery as it may affect a nursing infant to a small but noticeable degree.

Pediatric Uses

It should not be used for children younger than 16 years old.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.