Bicalon50 mg

Bicalon 50 mg 50 mg daily is indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of the prostate.Bicalon 50 mg 150 mg daily is not approved for use alone or with other treatments

Hormonal Chemotherapy

Bicalon 50 mg is a non-steroidal androgen receptor inhibitor. It competitively inhibits the action of androgens by binding to cytosol androgen receptors in the target tissue. Prostatic carcinoma is known to be androgen sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen.When Bicalon 50 mg is combined with luteinizing hormone releasing hormone (LHRH) analog therapy, the suppression of serum testosterone induced by the LHRH analog is not affected. However, in clinical trials with Bicalon 50 mg as a single agent for prostate cancer, rises in serum testosterone and estradiol have been noted.In a subset of patients who have been treated with Bicalon 50 mg and an LHRH agonist, and who discontinue Bicalon 50 mg therapy due to progressive advanced prostate cancer, a reduction in Prostate Specific Antigen (PSA) and/or clinical improvement (antiandrogen withdrawal phenomenon) may be observed.

The recommended dose for Bicalon 50 mg therapy in combination with an LHRH analog is one 50 mg tablet once daily (morning or evening), with or without food. It is recommended that Bicalon 50 mg be taken at the same time each day. Treatment with Bicalon 50 mg should be started at the same time as treatment with an LHRH analog.

The recommended dose for Bicalon 50 mg therapy in combination with an LHRH analog is one 50 mg tablet once daily (morning or evening), with or without food. It is recommended that Bicalon 50 mg be taken at the same time each day. Treatment with Bicalon 50 mg should be started at the same time as treatment with an LHRH analog.

May induce torsade de pointes or QT prolongation if co-administered with class IA (e.g. quinidine) or class III (e.g. amiodarone) antiarrhythmic agents, methadone, antipsychotics, moxifloxacin. Enhanced anticoagulant effect of warfarin. Increased adverse effects when used with drugs that may inhibit oxidation (e.g. cimetidine, ketoconazole). May increase serum levels of ciclosporin and Ca channel blockers.

Females, children, Pregnancy and lactation. Concomitant use of terfenadine, astemizole or cisapride.

Anaemia; angioedema, urticaria; decreased appetite, DM, wt gain, dehydration, gout; decreased libido, depression, anxiety, hypertonia, confusion, neuropathy, nervousness, dizziness, somnolence; hot flush; abdominal pain, constipation, nausea, dyspepsia, flatulence, anorexia, rectal haemorrhage, dry mouth, melaena; hepatotoxicity, jaundice, hypertransaminasaemia; alopecia, hirsutism, dry skin, pruritus/rash, photosensitivity; haematuria, dysuria, urinary retention, impaired urination, urinary frequency; gynaecomastia, breast tenderness, erectile dysfunction; asthenia, oedema, chest pain, neck pain, fever, sepsis, chills, neoplasm; cough, pharyngitis, bronchitis, pneumonia, rhinitis.

Pregnancy category X. Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.Nursing Mothers: Bicalon 50 mg is not indicated for use in women.

Patient with decreased bone density, history of or risk factors for QT prolongation, diabetes, Moderate to severe hepatic and severe renal impairment (CrCl <30 mL/min).

Long-term clinical trials have been conducted with dosages up to 200 mg of Bicalon 50 mg daily and these dosages have been well tolerated. A single dose of Bicalon 50 mg that results in symptoms of an overdose considered to be life threatening has not been established. There is no specific antidote; treatment of an overdose should be symptomatic.In the management of an overdose with Bicalon 50 mg, vomiting may be induced if the patient is alert. It should be remembered that, in this patient population, multiple drugs may have been taken. Dialysis is not likely to be helpful since Bicalon 50 mg is highly protein bound and is extensively metabolized. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.

Store at controlled room temperature, 20° to 25° C.

Renal Impairment: No dosage adjustment is necessary for patients with renal impairment.Hepatic Impairment: No dosage adjustment is necessary for patients with mild to moderate hepatic impairment. In patients with severe liver impairment (n=4), although there was a 76% increase in the half-life (5.9 and 10.4 days for normal and impaired patients, respectively) of the active enantiomer of Bicalon 50 mg no dosage adjustment is necessary.Pediatric Use: The safety and effectiveness of Bicalon 50 mg in pediatric patients have not been established.Geriatric Use: In two studies in patients given 50 or 150 mg daily, no significant relationship between age and steady-state levels of total Bicalon 50 mg or the active R-enantiomer has been shown.Women: Bicalon 50 mg has not been studied in women.

Hormonal Chemotherapy

Bicalon 50 mg is a non-steroidal androgen receptor inhibitor. It competitively inhibits the action of androgens by binding to cytosol androgen receptors in the target tissue. Prostatic carcinoma is known to be androgen sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen.When Bicalon 50 mg is combined with luteinizing hormone releasing hormone (LHRH) analog therapy, the suppression of serum testosterone induced by the LHRH analog is not affected. However, in clinical trials with Bicalon 50 mg as a single agent for prostate cancer, rises in serum testosterone and estradiol have been noted.In a subset of patients who have been treated with Bicalon 50 mg and an LHRH agonist, and who discontinue Bicalon 50 mg therapy due to progressive advanced prostate cancer, a reduction in Prostate Specific Antigen (PSA) and/or clinical improvement (antiandrogen withdrawal phenomenon) may be observed.

Pregnancy category X. Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.Nursing Mothers: Bicalon 50 mg is not indicated for use in women.

Renal Impairment: No dosage adjustment is necessary for patients with renal impairment.Hepatic Impairment: No dosage adjustment is necessary for patients with mild to moderate hepatic impairment. In patients with severe liver impairment (n=4), although there was a 76% increase in the half-life (5.9 and 10.4 days for normal and impaired patients, respectively) of the active enantiomer of Bicalon 50 mg no dosage adjustment is necessary.Pediatric Use: The safety and effectiveness of Bicalon 50 mg in pediatric patients have not been established.Geriatric Use: In two studies in patients given 50 or 150 mg daily, no significant relationship between age and steady-state levels of total Bicalon 50 mg or the active R-enantiomer has been shown.Women: Bicalon 50 mg has not been studied in women.