Briva

Briva50 mg

Tablet

Brivaracetam

ACME Laboratories Ltd.

Product Code : 2471
MRP 60.00
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Medicine overview

Indications of Briva 50 mg

Briva 50 mg is indicated for the treatment of partial-onset seizures in patients 4 years of age and older. As the safety of Briva 50 mg injection in pediatric patients has not been established, Briva 50 mg injection is indicated for the treatment of partial-onset seizures only in adult patients (16 years of age and older).

Theropeutic Class

Adjunct anti-epileptic drugs

Pharmacology

The precise mechanism by which Briva 50 mg exerts its anticonvulsant activity is not known. Briva 50 mg displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to the anticonvulsant effect.Briva 50 mg binds SV2A with high affinity. SV2A is known to play a role in epileptogenesis through modulation of synaptic GABA release. It is thought that Briva 50 mg exerts its anti-epileptogenic effects through its binding to SV2A. Briva 50 mg is also known to inhibit Na+ channels which may also contribute to its anti-epileptogenic action

Dosage of Briva 50 mg

Adults (16 Years and older): The recommended starting dosage for monotherapy or adjunctive therapy is 50 mg twice daily (100 mg per day).Based on individual patient tolerability and therapeutic response, the dosage may be adjusted down to 25 mg twice daily (50 mg per day) or up to 100 mg twice daily (200 mg per day).Pediatric Patients (4 Years to less than 16 Years): The recommended dosage is based on body weight and is administered orally twice dailyInjection: for intravenous and adult use only when oral administration is temporarily not feasible; dosing is the same as oral regimen.

Administration of Briva 50 mg

Briva 50 mg injection should be administered intravenously over 2 to 15 minutes. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Product with particulate matter or discoloration should not be used. Briva 50 mg injection is for single dose only.

Interaction of Briva 50 mg

Rifampin: Because of decreased concentrations, increasing Briva 50 mg dosage in patients on concomitant rifampin is recommended.Carbamazepine: Because of increased exposure to carbamazepine metabolite, if tolerability issues arise, consider reducing carbamazepine dosage in patients on concomitant Briva 50 mg.Phenytoin: Because phenytoin concentrations can increase, phenytoin levels should be monitored in patients on concomitant Briva 50 mg.Levetiracetam: Briva 50 mg had no added therapeutic benefit when co-administered with levetiracetam.

Contraindications

Hypersensitivity to Briva 50 mg or any of the inactive ingredients in Briva 50 mg

Side Effects of Briva 50 mg

Most common adverse reactions (at least 5% for Briva 50 mg and at least 2% more frequently than placebo) are somnolence/sedation, dizziness, fatigue, and nausea or vomiting.

Pregnancy & Lactation

There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), such as Briva 50 mg, during pregnancy. No data are available regarding the presence of Briva 50 mg in human milk, the effects on the breastfed infant, or the effects of the drug on milk production. Studies in lactating rats have shown excretion of Briva 50 mg or metabolites in milk

Precautions & Warnings

Suicidal Behavior and Ideation: Monitor patients for suicidal behavior and ideation.Neurological Adverse Reactions: Monitor for somnolence and fatigue, and advise patients not to drive or operate machinery until they have gained sufficient experience on Briva 50 mg.Psychiatric Adverse Reactions: Behavioral reactions including psychotic symptoms, irritability, depression, aggressive behavior, and anxiety; monitor patients for symptoms.Hypersensitivity: Bronchospasm and Angioedema: Advise patients to seek immediate medical care. Discontinue and do not restart Briva 50 mg if hypersensitivity occurs. Withdrawal of Antiepileptic Drugs: Briva 50 mg should be gradually withdrawn.

Storage Conditions

Store at 25°C; excursions permitted between 15°C to 30°C

Use In Special Populations

Hepatic Impairment: Dose adjustment is recommended for all stages of hepatic impairment.Renal Impairment: Dose adjustments are not required for patients with impaired renal function.

Drug Classes

Adjunct anti-epileptic drugs

Mode Of Action

The precise mechanism by which Briva 50 mg exerts its anticonvulsant activity is not known. Briva 50 mg displays a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to the anticonvulsant effect.Briva 50 mg binds SV2A with high affinity. SV2A is known to play a role in epileptogenesis through modulation of synaptic GABA release. It is thought that Briva 50 mg exerts its anti-epileptogenic effects through its binding to SV2A. Briva 50 mg is also known to inhibit Na+ channels which may also contribute to its anti-epileptogenic action

Pregnancy

There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), such as Briva 50 mg, during pregnancy. No data are available regarding the presence of Briva 50 mg in human milk, the effects on the breastfed infant, or the effects of the drug on milk production. Studies in lactating rats have shown excretion of Briva 50 mg or metabolites in milk

Pediatric Uses

Hepatic Impairment: Dose adjustment is recommended for all stages of hepatic impairment.Renal Impairment: Dose adjustments are not required for patients with impaired renal function.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.