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Carboplat10 mg/ml
Beacon Pharmaceuticals PLC
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Carboplatin10 mg/ml
IV Infusion
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Medicine overview
Indications of Carboplatin 10 mg/ml
both in combination with cyclophosphamidethose who have developed progressive disease while receiving cisplatin therapy may have a decreased response rate.
Theropeutic Class
Cytotoxic Chemotherapy
Pharmacology
Carboplatin 10 mg/ml is an alkylating agent which binds covalently to DNA.
Absorption
It modifies the cell cycle by interfering with DNA structure and function.
Dosage & Administration of Carboplatin 10 mg/ml
Previously untreated patients
Dosage:400 mg/m2 as single short term IV infusion over 15-60 min
Notes:Therapy should not be repeated until 4 wk after the previous course and/or until the neutrophil count is at least 2,000 cells/mm3 and the platelet count is at least 100,000 cells/mm3. Patients previously treated with myelosuppresive therapy or patients with poor performance status: Reduce initial dosage by 20-25% (300-320 mg/m2)
| Condition | Dosage | Notes |
|---|---|---|
| Previously untreated patients | 400 mg/m2 as single short term IV infusion over 15-60 min | Therapy should not be repeated until 4 wk after the previous course and/or until the neutrophil count is at least 2,000 cells/mm3 and the platelet count is at least 100,000 cells/mm3. Patients previously treated with myelosuppresive therapy or patients with poor performance status: Reduce initial dosage by 20-25% (300-320 mg/m2) |
Dosage of Carboplatin 10 mg/ml
Previously untreated patients
Dosage:400 mg/m2 as single short term IV infusion over 15-60 min
Notes:Therapy should not be repeated until 4 wk after the previous course and/or until the neutrophil count is at least 2,000 cells/mm3 and the platelet count is at least 100,000 cells/mm3. Patients previously treated with myelosuppresive therapy or patients with poor performance status: Reduce initial dosage by 20-25% (300-320 mg/m2)
| Condition | Dosage | Notes |
|---|---|---|
| Previously untreated patients | 400 mg/m2 as single short term IV infusion over 15-60 min | Therapy should not be repeated until 4 wk after the previous course and/or until the neutrophil count is at least 2,000 cells/mm3 and the platelet count is at least 100,000 cells/mm3. Patients previously treated with myelosuppresive therapy or patients with poor performance status: Reduce initial dosage by 20-25% (300-320 mg/m2) |
Interaction of Carboplatin 10 mg/ml
Administration of a liver vaccine may be dangerous during treatment with Carboplatin 10 mg/ml. The renal effects of nephrotoxic compounds may be potentiated by Carboplatin 10 mg/ml.
Contraindications
Carboplatin 10 mg/ml injection should not be employed in patients with severe bone marrow depression or significant bleeding. It is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum containing compounds.
Side Effects of Carboplatin 10 mg/ml
Bone marrow suppression, gastrointestinal effects, nephrotoxicity, nervous system, ototoxicity, allergic reactions, alopecia, mucositis.
Pregnancy & Lactation
Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk
Precautions & Warnings
Much less renal toxicity than cisplatin so no need for a vigorousm hydration schedule or forced diuresis. If AUC dosing is not used, dose should be reduced to 250 mg/m2 for creatinine clearance of 41 to 59 ml/min and to 200 mg/m2 for clearance of 16 to 40 ml/min. Corticosteroids & antihistamines are employed to alleviate symptoms.
Storage Conditions
Store at 25° C. Protect from light.
Use In Special Populations
Renal Impairment:
CrCl (16-40 ml/min)- 200 mg/m2.
CrCl (41-59 ml/min)- 250 mg/m2.
Reconstitution
150 mg injection should be reconstituted with 15 ml of sodium chloride solution (0.9%) or water for injection.450 mg injection should be reconstituted with 45 ml of sodium chloride solution (0.9%) or water for injection.The reconstituted solution should be diluted by 300 ml (for 150 mg) & 900 ml (for 450 mg) of 5% glucose for injection or 0.9% sodium chloride solution for infusition.
Drug Classes
Cytotoxic Chemotherapy
Mode Of Action
Carboplatin 10 mg/ml is an alkylating agent which binds covalently to DNA. It modifies the cell cycle by interfering with DNA structure and function.
Pregnancy
Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk
Pediatric Uses
Renal Impairment:
CrCl (16-40 ml/min)- 200 mg/m2.
CrCl (41-59 ml/min)- 250 mg/m2.
Frequently Asked Questions
What is Carboplatin 10 mg/ml used for?
Initial Treatment of Advanced Ovarian Carcinoma: Carboplatin is indicated for the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimenconsists of Carboplatin and cyclophosphamide. ... Read moreInitial Treatment of Advanced Ovarian Carcinoma: Carboplatin is indicated for the initial treatment of a…
What is the dosage of Carboplatin 10 mg/ml?
Previously untreated patients: 400 mg/m2 as single short term IV infusion over 15-60 min. Therapy should not be repeated until 4 wk after the previous course and/or until the neutrophil count is at least 2,000 cells/mm3 and the platelet count is at least 100,000 cells/mm3. Patients previously treated with myelosuppresive therapy or patients with poor performance status: Reduce initial dosage by 20…
What are the side effects of Carboplatin 10 mg/ml?
Bone marrow suppression, gastrointestinal effects, nephrotoxicity, nervous system, ototoxicity, allergic reactions, alopecia, mucositis.
Who should not take Carboplatin 10 mg/ml?
Carboplatin injection should not be employed in patients with severe bone marrow depression or significant bleeding. It is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum containing compounds.
What precautions should be taken with Carboplatin 10 mg/ml?
Much less renal toxicity than cisplatin so no need for a vigorousm hydration schedule or forced diuresis. If AUC dosing is not used, dose should be reduced to 250 mg/m2 for creatinine clearance of 41 to 59 ml/min and to 200 mg/m2 for clearance of 16 to 40 ml/min. Corticosteroids & antihistamines are employed to alleviate symptoms.
Is Carboplatin 10 mg/ml safe during pregnancy and breastfeeding?
Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.